56 completed, 18 terminated, 3 withdrawn, 1 active not recruiting. 46 Phase 2, 45 Phase 1, 5 Not applicable, 2 Early Phase 1.
Follow Adult Gliosarcoma: new trials by email Literature Review of Adult Gliosarcoma trials Research Report on Adult Gliosarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Maximum Tolerated Dose, Safety and Efficiency of MSC11FCD Therapy to Recurrent Glioblastoma Patients MSC11FCD - Glioblastoma, Adult Gliosarcoma | Phase 1 / Phase 2 | Completed | CHA University | 10 | 2020-06-24 | 2023-01-18 |
| EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma EGFRBi-Armed Autologous T Cells, Laboratory Biomarker Analysis - Adult Brain Glioblastoma, Adult Gliosarcoma | Phase 1 / Phase 2 | Withdrawn | Barbara Ann Karmanos Cancer Institute | 2015-08-01 | 2016-02-15 | |
| Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Dimethyl Fumarate, Temozolomide, Radiation Therapy - Adult Brain Glioblastoma, Adult Giant Cell Glioblastoma | Phase 1 | Completed | Virginia Commonwealth University | 12 | 2015-02-13 | 2019-06-28 |
| Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas Hyperfractionated radiation therapy, Stereotactic radiosurgery, Alisertib - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 17 | 2015-01-30 | 2025-04-30 |
| 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas 18F-fluoro-dihydroxyphenylalanine, Positron emission tomography (PET), Computed tomography (CT) - Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma | Not applicable | Terminated | Erik Mittra | 2 | 2014-12-01 | 2017-03-20 |
| Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma radiation therapy, temozolomide, plerixafor - Adult Ependymoblastoma, Adult Giant Cell Glioblastoma | Phase 1 / Phase 2 | Completed | Lawrence Recht | 30 | 2014-11-01 | 2018-10-23 |
| Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas E. coli CD-expressing genetically modified neural stem cells, flucytosine, leucovorin calcium - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 | Completed | City of Hope Medical Center | 16 | 2014-10-28 | 2026-11-03 |
| NovoTTF-100A With Bevacizumab (Avastin) in Patients With Recurrent Glioblastoma Bevacizumab, NovoTTF-l00A, Quality of Life Assessment - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Completed | Case Comprehensive Cancer Center | 25 | 2013-09-18 | 2025-02-17 |
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy 18F-fludeoxyglucose (18F-FDG), 18F-FPPRGD2 - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 1 / Phase 2 | Completed | Sanjiv Sam Gambhir | 25 | 2013-03-04 | 2019-10-03 |
| Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma dovitinib, laboratory biomarker analysis - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Completed | Manmeet Ahluwalia, MD | 33 | 2012-12-20 | 2017-12-12 |
| Bevacizumab With or Without Radiation Therapy in Treating Patients With Recurrent Glioblastoma bevacizumab, radiation therapy - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Completed | Radiation Therapy Oncology Group | 182 | 2012-12-20 | 2022-12-29 |
| Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme Anti-Endoglin Chimeric Monoclonal Antibody TRC105, Bevacizumab, Laboratory Biomarker Analysis - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 116 | 2012-11-01 | 2018-05-23 |
| High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating Patients With Recurrent Glioma Vorinostat, Stereotactic Radiosurgery, Laboratory Biomarker Analysis - Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma | Phase 1 | Terminated | National Cancer Institute (NCI) | 30 | 2012-06-01 | 2014-12-23 |
| Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme aminolevulinic acid, therapeutic conventional surgery - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 2 | Terminated | Michael Vogelbaum, MD, PhD | 8 | 2012-05-01 | 2018-07-31 |
| 3T MRI Biomarkers of Glioma Treatment Response 3-Tesla magnetic resonance imaging, CEST-MRI, DW-MRI - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Early Phase 1 | Terminated | Vanderbilt-Ingram Cancer Center | 7 | 2012-05-01 | 2017-04-17 |
| Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Gadobenate Dimeglumine, Gadobutrol - Adult Anaplastic (Malignant) Meningioma, Adult Anaplastic Astrocytoma | Not applicable | Terminated | University of Southern California | 14 | 2011-12-14 | 2017-03-27 |
| RO4929097 in Treating Patients With Recurrent Invasive Gliomas gamma-secretase/Notch signalling pathway inhibitor RO4929097, therapeutic conventional surgery, pharmacological study - Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma | Phase 1 | Terminated | National Cancer Institute (NCI) | 22 | 2011-07-01 | 2013-02-07 |
| Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases bafetinib, microdialysis, pharmacological study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | City of Hope Medical Center | 7 | 2010-12-01 | 2018-04-17 |
| Yoga Therapy in Treating Patients With Malignant Brain Tumors yoga therapy, questionnaire administration, quality-of-life assessment - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Not applicable | Terminated | Wake Forest University Health Sciences | 9 | 2010-12-01 | 2018-07-03 |
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Gliosarcoma (78) · Glioblastoma (77) · Brain Neoplasms (54) · Astrocytoma (33) · Oligodendroglioma (33) · Glioma (24) · Ependymoma (13) · Neuroectodermal Tumors, Primitive (7) · Glioma, Subependymal (6) · Medulloblastoma (6) · Meningioma (6) · Pinealoma (6) · Choroid Plexus Neoplasms (5) · Breast Neoplasms (3) · Breast Neoplasms, Male (3)
Neoplasms (78) · Neoplasms by Histologic Type (78) · Neoplasms, Glandular and Epithelial (78) · Neoplasms, Nerve Tissue (78) · Neuroectodermal Tumors (78) · Neoplasms, Germ Cell and Embryonal (77) · Neoplasms, Neuroepithelial (76) · Brain Diseases (57) · Central Nervous System Diseases (57) · Neoplasms by Site (57) · Nervous System Diseases (57) · Nervous System Neoplasms (57) · Central Nervous System Neoplasms (56) · Glioma (54) · Astrocytoma (44)
Temozolomide (15) · Radiotherapy (11) · Radiation (10) · Radiotherapy, Conformal (8) · Erlotinib Hydrochloride (7) · Magnetic Resonance Spectroscopy (7) · Sirolimus (6) · temsirolimus (6) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (5) · Bevacizumab (5) · Radiotherapy, Intensity-Modulated (5) · Vorinostat (5) · cediranib (5) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (4) · Cilengitide (4)
National Cancer Institute (NCI) (55) · City of Hope Medical Center (4) · University of Washington (2) · Wake Forest University Health Sciences (2) · Barbara Ann Karmanos Cancer Institute (1) · CHA University (1) · Case Comprehensive Cancer Center (1) · Erik Mittra (1) · Lawrence Recht (1) · Manmeet Ahluwalia, MD (1) · Mayo Clinic (1) · Michael Vogelbaum, MD, PhD (1) · Radiation Therapy Oncology Group (1) · Sanjiv Sam Gambhir (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1)
United States (74) · Canada (3) · Saudi Arabia (1) · South Korea (1)
Evanthia Galanis (5) · Jana Portnow (4) · David Peereboom, MD (3) · Elizabeth Gerstner (2) · Howard Fine, MD (2) · Mark Gilbert (2) · Timothy Cloughesy (2) · Tracy Batchelor (2) · Adam P. Dicker, MD, PhD (1) · Andrew Lassman (1) · Antonio Omuro (1) · Antonius Miller (1) · Arnab Chakravarti (1) · Chad Quarles (1) · Charles Nock, MD (1)
PMID 25113840, PMID 18955445, PMID 20200024, PMID 20458050, PMID 21377994, PMID 21632852, PMID 22517399, PMID 23328813, PMID 23380277, PMID 24309981, PMID 24470557, PMID 25758746, PMID 25832688, PMID 25965900, PMID 26062933, PMID 26611425, PMID 27185374, PMID 29902200, PMID 30825962, PMID 30850872, PMID 31386061, PMID 33842889, PMID 36260832, PMID 38197800
U01CA062475 (10), U01CA062399 (9), U10CA025224 (9), U01CA137443 (8), U10CA021661 (6), U10CA180821 (3), P30CA008748 (2), P30CA124435 (2), U01CA069856 (2), U10CA180868 (2), N01CM00032 (1), N01CM62203 (1), N01CM62206 (1), N01CM62207 (1), P30CA006516 (1)