6 completed, 2 recruiting, 2 unknown, 1 not yet recruiting. 12 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 6, Recruiting 2, Unknown 2, Not yet recruiting 1, Terminated 1 |
Follow Adrenoleukodystrophy: new trials by email Literature Review of Adrenoleukodystrophy trials Research Report on Adrenoleukodystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IT and IV Lentiviral Gene Therapy for X-ALD Intrathecal and intravenous LV gene therapy - X-linked Adrenoleukodystrophy | Not applicable | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-01 | 2026-11-02 |
| Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy Spinal cord stimulation - Adrenomyeloneuropathy Without Cerebral Involvement | Not applicable | Recruiting | Third Military Medical University | 10 | 2025-02-10 | 2025-01-28 |
| Home Exercise for Individuals With Neurodegenerative Disease Home exercise - Neurodegenerative Diseases, Leukodystrophy | Not applicable | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 30 | 2023-02-13 | 2026-09-16 |
| SMART-ALD - A New Lifestyle Intervention to Improve Quality of Life in Women With X-linked Adrenoleukodystrophy (X-ALD) SMART-ALD, Waiting list - X-linked Adrenoleukodystrophy | Not applicable | Completed | Leipzig University Medical Center | 68 | 2022-05-20 | 2024-03-13 |
| Precision Exercise in Children With Malignant Hemopathies Sport Therapy - Leukemia, Myeloid, Acute, Leukemia, B-cell | Not applicable | Unknown | University of Milano Bicocca | 380 | 2017-04-03 | 2024-01-02 |
| Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy rTMS - Hereditary Spastic Paraplegia, Adrenomyeloneuropathy | Not applicable | Completed | Jakub Antczak | 15 | 2017-01-09 | 2021-09-27 |
| Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders Campath-1H, Clofarabine, Melphalan - Lysosomal Storage Disease, Peroxisomal Disorder | Not applicable | Completed | Masonic Cancer Center, University of Minnesota | 3 | 2012-07-11 | 2017-12-05 |
| Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy exercise training - X-linked Adrenoleukodystrophy | Not applicable | Completed | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 31 | 2012-05-01 | 2018-08-29 |
| The Effect of Bezafibrate on the Level of Very Long Chain Fatty Acids (VLCFA) in X-linked Adrenoleukodystrophy (X-ALD) Bezafibrate - X-linked Adrenoleukodystrophy, Adrenomyeloneuropathy | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 10 | 2010-07-01 | 2011-08-10 |
| Clinical Study and Gene Mutation Analysis of Adrenoleukodystrophy in Taiwanese Children blood sampling and medical records - Adrenoleukodystrophy | Not applicable | Unknown | Far Eastern Memorial Hospital | 20 | 2006-01-01 | 2009-02-09 |
| Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy glyceryl trierucate, glyceryl trioleate, interferon beta - Adrenoleukodystrophy | Not applicable | Completed | FDA Office of Orphan Products Development | 60 | 1998-08-01 | 2015-03-25 |
| Study of Bile Acids in Patients With Peroxisomal Disorders chenodeoxycholic acid, cholic acid, ursodiol - Infantile Refsum's Disease, Zellweger Syndrome | Not applicable | Terminated | University of Cincinnati | 25 | 2015-03-25 |
Peroxisomal Disorders (3) · Rare Diseases (3) · Metabolism, Inborn Errors (2) · Motor Activity (2) · Sphingolipidoses (2) · Ataxia (1) · Central Nervous System Diseases (1) · Cerebellar Ataxia (1) · Gangliosidosis, GM1 (1) · Genetic Diseases, Inborn (1) · Genetic Diseases, X-Linked (1) · Hodgkin Disease (1) · Leukemia (1) · Leukemia, B-Cell (1)
Adrenal Gland Diseases (12) · Adrenal Insufficiency (12) · Brain Diseases (12) · Brain Diseases, Metabolic (12) · Brain Diseases, Metabolic, Inborn (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Demyelinating Diseases (12) · Endocrine System Diseases (12) · Hereditary Central Nervous System Demyelinating Diseases (12) · Heredodegenerative Disorders, Nervous System (12) · Intellectual Disability (12) · Leukoencephalopathies (12) · Metabolic Diseases (12) · Nervous System Diseases (12) · Neurobehavioral Manifestations (12)
Alemtuzumab (1) · Bezafibrate (1) · Blood Specimen Collection (1) · Chenodeoxycholic Acid (1) · Cholic Acid (1) · Clofarabine (1) · Cyclosporine (1) · Exercise (1) · Hematopoietic Stem Cell Transplantation (1) · Interferon-beta (1) · Medical Records (1) · Melphalan (1) · Mycophenolic Acid (1) · Radiotherapy, Intensity-Modulated (1) · Resistance Training (1)
Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · FDA Office of Orphan Products Development (1) · Far Eastern Memorial Hospital (1) · Jakub Antczak (1) · Leipzig University Medical Center (1) · Masonic Cancer Center, University of Minnesota (1) · Shenzhen Geno-Immune Medical Institute (1) · Third Military Medical University (1) · University of Cincinnati (1) · University of Milano Bicocca (1)
United States (3) · China (2) · Germany (1) · Italy (1) · Netherlands (1) · Poland (1) · Taiwan (1)
Andrea Biondi, MD, PhD (1) · Hugo Wolfgang Moser (1) · Jakub M Antczak, MD (1) · Jao Shwann Liang, MD (1) · Jennifer Keller, PT (1) · Kathleen M Zackowski, Ph.D. (1) · Kenneth Setchell (1) · Weston Miller, MD (1)