5 recruiting, 1 active not recruiting, 1 completed. 3 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Recruiting 3 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Acute Otitis Media (AOM): new trials by email Literature Review of Acute Otitis Media (AOM) trials Research Report on Acute Otitis Media (AOM)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media) Amoxicillin, Amoxicillin-Clavulanate, Amoxicillin Placebo - Acute Otitis Media (AOM) | Phase 4 | Recruiting | Nader Shaikh | 1100 | 2026-10-01 | 2026-10-20 |
| Artificial Intelligence Diagnostic Decision Support to Reduce Antimicrobial Prescriptions in Young Children With Colds Standard Clinical Ear Exam, AI app ear exam and diagnosis - Acute Otitis Media (AOM), Upper Respiratory Infection | Not applicable | Recruiting | Timothy Shope | 300 | 2025-12-04 | 2026-10-08 |
| Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care Antibiotic prescribing according to guidelines - Angina, Acute Bronchiolitis | Not applicable | Recruiting | University Hospital, Caen | 4500 | 2025-12-01 | 2026-01-22 |
| Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group - Acute Otitis Media (AOM), Strep Pharyngitis | Not applicable | Recruiting | Medentum Innovations | 84 | 2025-10-01 | 2026-03-30 |
| Safety and Efficacy of wSp Vaccine in Young Children wSp vaccine, Saline (0.9% NaCl) - Acute Otitis Media (AOM) | Phase 2 | Recruiting | Serum Life Science Europe GmbH | 320 | 2025-09-29 | 2026-09-23 |
| Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support - Community Acquired Pneumonia (CAP), Sinusitis | Active not recruiting | Children's Hospital of Philadelphia | 420 | 2025-02-18 | 2026-04-14 | |
| V114 and Acute Otitis Media (V114-032/PNEU-ERA) V114, Pediatric vaccines - Acute Otitis Media (AOM) | Phase 3 | Completed | Merck Sharp & Dohme LLC | 7119 | 2020-09-12 | 2026-01-22 |
Otitis Media (7) · Community-Acquired Pneumonia (2) · Respiratory Tract Infections (2) · Angina Pectoris (1) · Bronchitis (1) · Disease (1) · Influenza, Human (1) · Laryngitis (1) · Nasopharyngitis (1) · Otitis (1) · Rhinitis (1) · Sinusitis (1)
Ear Diseases (7) · Otorhinolaryngologic Diseases (7) · Otitis (6) · Infections (3) · Respiratory Tract Diseases (3) · Community-Acquired Infections (2) · Nose Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Pneumonia (2) · Bronchial Diseases (1) · Cardiovascular Diseases (1) · Chest Pain (1) · Heart Diseases (1) · Laryngeal Diseases (1) · Lung Diseases (1)
Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Diagnosis (1) · Sodium Chloride (1)
Children's Hospital of Philadelphia (1) · Medentum Innovations (1) · Merck Sharp & Dohme LLC (1) · Nader Shaikh (1) · Serum Life Science Europe GmbH (1) · Timothy Shope (1) · University Hospital, Caen (1)
United States (5) · France (1) · Thailand (1)
Louis Bell, MD (1) · Nader Shaikh, MD (1) · Rebecca Same, MD (1) · Timothy R Shope, MD, MPH (1)
2023 (1), U01AI172733 (1)