15 completed, 11 recruiting, 7 unknown, 4 not yet recruiting. 45 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 45 | Completed 15, Recruiting 11, Unknown 7, Not yet recruiting 4, Terminated 3, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1 |
Follow Acute Hypoxemic Respiratory Failure: new trials by email Literature Review of Acute Hypoxemic Respiratory Failure trials Research Report on Acute Hypoxemic Respiratory Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning - Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy | Not applicable | Not yet recruiting | Rush University Medical Center | 2000 | 2026-11-01 | 2026-09-25 |
| Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure FreeO2 automated oxygen titration system, Standard oxygen weaning - Acute Hypoxemic Respiratory Failure, Hypoxemia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 40 | 2026-09-15 | 2026-08-31 |
| Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure Spontaneous Ventilation Strategy, Controlled Ventilation Strategy - Acute Respiratory Distress Syndrome (ARDS), Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Oslo University Hospital | 80 | 2026-09-01 | 2026-10-15 |
| Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure Bag CPAP, Standard oxygen - Acute Hypoxemic Respiratory Failure | Not applicable | Not yet recruiting | Prof RWABIHAMA Jean Paul | 250 | 2026-04-20 | 2026-03-19 |
| IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure Restrictive intubation strategy, Liberal intubation strategy - Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | University Hospital, Angers | 200 | 2025-12-13 | 2026-08-07 |
| Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation Variation of Pressure Support Levels - Acute Hypoxemic Respiratory Failure, Mechanical Ventilation Complication | Not applicable | Recruiting | Centre for Medical Sciences | 36 | 2025-10-08 | 2026-06-05 |
| PEEP-induced Effects on Respiratory dRivE and EFfort PEEP level changes - ARDS (Moderate or Severe), Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Radboud University Medical Center | 20 | 2025-09-02 | 2025-11-17 |
| Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure Low-flow ECMO - Acute Hypoxemic Respiratory Failure, Mechanical Ventilation | Not applicable | Enrolling by invitation | Institute for Extracorporeal Life Support | 30 | 2025-05-01 | 2025-04-22 |
| Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia Awake Prone Positioning - Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 342 | 2025-04-11 | 2026-05-04 |
| Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial Continuous Positive Airway Pressure, High-flow nasal oxygen, Non-invasive ventilation - Acute Hypoxemic Respiratory Failure, High-Flow Nasal Oxygen Therapy | Not applicable | Recruiting | Southeast University, China | 1300 | 2025-01-23 | 2025-02-26 |
| EIT-Guided Ventilator Settings in AHRF Electrical Impedance Tomography (EIT), Enlight 2100 - Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Not applicable | Recruiting | Mahidol University | 17 | 2024-12-17 | 2025-04-27 |
| Early Switch From Controlled to Assisted Ventilation Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg - Acute Hypoxemic Respiratory Failure, Mechanical Ventilation | Not applicable | Completed | Erasmus Medical Center | 20 | 2024-09-15 | 2026-09-16 |
| Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients Education, Epic notification alert - Respiratory Failure, Acute Hypoxemic Respiratory Failure | Not applicable | Active not recruiting | University of Colorado, Denver | 3600 | 2024-09-01 | 2026-09-28 |
| Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout. Investigational full-face mask with expiratory washout, Conventional full-face mask - single-limb, Conventional full-face mask - dual-limb - Acute Hypercapnic Respiratory Failure, Acute Hypoxemic Respiratory Failure | Not applicable | Unknown | Fisher and Paykel Healthcare | 32 | 2024-05-06 | 2025-03-14 |
| Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT) Closed-loop FiO2 controller, Conventional - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Recruiting | Başakşehir Çam & Sakura City Hospital | 50 | 2024-03-21 | 2025-01-28 |
| Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure HFNC only, HFNC + CNEP10, HFNC + CNEP20 - Acute Hypoxemic Respiratory Failure | Not applicable | Recruiting | NYU Langone Health | 20 | 2024-02-28 | 2026-10-01 |
| Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care HFNO weaning protocol, HFNO Standard of care - Acute Hypoxemic Respiratory Failure, High-flow Nasal Oxygen Therapy | Not applicable | Recruiting | University Hospital, Tours | 370 | 2024-02-17 | 2025-07-30 |
| Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure Experimental: Asymmetrical high-flow nasal cannula, Active comparator: Conventional high-flow nasal cannula - Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure | Not applicable | Completed | Siriraj Hospital | 40 | 2024-01-20 | 2026-04-24 |
| Physiology of Helmet vs. Facemask Noninvasive Ventilation Noninvasive ventilation - Acute Hypoxemic Respiratory Failure | Not applicable | Completed | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2024-01-19 | 2025-09-30 |
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Respiratory Insufficiency (45) · COVID-19 (6) · Respiratory Distress Syndrome (6) · Hypoxia (3) · Acute Lung Injury (1) · Community-Acquired Pneumonia (1) · Hematologic Neoplasms (1) · Lung Injury (1) · Lymphoma, Follicular (1) · Obesity (1) · Pulmonary Atelectasis (1) · Thromboembolism (1) · Ventilator-Induced Lung Injury (1)
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