13 completed, 1 unknown. 8 Phase 2, 3 Phase 4, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 7, Unknown 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TMC (Topotecan, Cyclophosphamide and Melphalan) for Multiple Myeloma Topotecan, Cyclophosphamide, Melphalan - Myeloma | Phase 2 | Completed | M.D. Anderson Cancer Center | 60 | 2002-02-18 | 2018-11-07 |
| Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients paroxetine, ongoing psychological screening - Depression, Hypertension | Phase 4 | Completed | US Department of Veterans Affairs | 2001-03-01 | 2009-01-21 | |
| Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) Insulin, Glimepiride, Rosiglitazone - Type 2 Diabetes Mellitus | Phase 3 | Completed | VA Office of Research and Development | 1791 | 2000-12-01 | 2017-03-30 |
| Effects of Rosiglitazone and Metformin on Metabolism in Type 2 Diabetes Rosiglitazone, Metformin, Placebo - Insulin Sensitivity, Type 2 Diabetes | Phase 4 | Completed | Turku University Hospital | 48 | 2000-10-01 | 2015-08-18 |
| An Evaluation of Weekly Tafenoquine Tafenoquine, Mefloquine, Placebo - Falciparum Parasitaemia | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 306 | 2000-05-01 | 2017-05-30 |
| A Phase I/II Study of Induction Chemotherapy With Daunorubicin, Cytarabine, Topotecan and Etoposide Cytarabine, Daunorubicin, Etoposide - Leukemia | Phase 1 / Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 41 | 1999-07-01 | 2012-09-25 |
| A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum Placebo, Tafenoquine 25mg, Tafenoquine 50mg - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 521 | 1998-08-01 | 2018-09-13 |
| Use of Topotecan in Patients With Refractory Acute Leukemia Topotecan, Mitozantrone, Etoposide - Non-Hodgkin's Lymphoma, Leukemia | Phase 2 | Completed | US Department of Veterans Affairs | 10 | 1998-08-01 | 2013-09-25 |
| Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma etoposide phosphate, melphalan, topotecan - Multiple Myeloma, Plasma Cell Neoplasm | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 131 | 1998-06-02 | 2019-11-08 |
| Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment Augmentin, Ceftriaxone, Cefotaxime, netilmycin, tobramycin, compare 8 to15 days of antibiotic treatment - Pneumonia Ventilator Associated | Phase 4 | Completed | Centre Hospitalier Universitaire de Besancon | 225 | 1998-01-01 | 2012-03-21 |
| Sequential Chemotherapy in Treating Patients With Residual Disease Following Surgery for Stage IIB, Stage III, or Stage IV Ovarian Cancer carboplatin, paclitaxel, topotecan hydrochloride - Ovarian Cancer | Phase 2 | Unknown | SmithKline Beecham | 40 | 1997-12-01 | 2013-09-20 |
| Evaluation of Weekly Tafenoquine Tafenoquine, Placebo - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 249 | 1997-05-01 | 2018-09-13 |
| A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis Albendazole - Protozoan Infections, HIV Infections | Phase 3 | Completed | SmithKline Beecham | 2005-06-24 | ||
| Safety and Effectiveness of Topotecan HCl to Treat HIV-Infected Patients With AIDS-Related Progressive Multifocal Leukoencephalopathy (PML) Topotecan - HIV Infections, Leukoencephalopathy, Progressive Multifocal | Phase 2 | Completed | SmithKline Beecham | 54 | 2005-06-24 |
Malaria (3) · AIDS-Related Opportunistic Infections (2) · Diabetes Mellitus, Type 2 (2) · HIV Infections (2) · Insulin Resistance (2) · Leukemia (2) · Multiple Myeloma (2) · Neoplasms, Plasma Cell (2) · Carcinoma, Ovarian Epithelial (1) · Congenital Abnormalities (1) · Depression (1) · Hypertension (1) · Intestinal Diseases (1) · Leukemia, Erythroblastic, Acute (1) · Leukemia, Megakaryoblastic, Acute (1)
Topotecan (6) · tafenoquine (3) · Etoposide (2) · Mefloquine (2) · Melphalan (2) · Metformin (2) · Rosiglitazone (2) · Albendazole (1) · Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Carboplatin (1) · Cefotaxime (1) · Ceftriaxone (1) · Clavulanic Acid (1) · Cyclophosphamide (1)
United States (8) · Finland (1) · Puerto Rico (1) · United Kingdom (1)
A.J Oloo (1) · Braden Hale, MD (1) · Carlos Abraira, MD (1) · Daniel M. Sullivan, M.D. (1) · Gordon J.S. Rustin, MD (1) · Hussain I. Saba, MD, PhD (1) · Jose Stoute, MD (1) · Mark Mainwaring (1) · Michelle Donato, MD (1) · Pirjo Nuutila, MD, PhD (1) · William Duckworth, MD (1)
PMID 28495354, PMID 11347758, PMID 14583175, PMID 14970858, PMID 16043738, PMID 16504835, PMID 16627388, PMID 16784922, PMID 18406632, PMID 18671796, PMID 19092145, PMID 19655124, PMID 19720420, PMID 19726779, PMID 19898642, PMID 20807873, PMID 21059830, PMID 21775749, PMID 22952580, PMID 23536583, PMID 25048382, PMID 25456099, PMID 26039600, PMID 26786575, PMID 27006510, PMID 28778047, PMID 30455335, PMID 31167051, PMID 33367811