28 completed, 15 unknown, 3 recruiting, 1 not yet recruiting. 48 Phase 3, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 48 | Completed 28, Unknown 15, Recruiting 3, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 14 | Completed 6, Unknown 5, Recruiting 2, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in Africa Dolutegravir (DTG), Abacavir (ABC), Lamivudine (3TC) - HIV Infection | Phase 3 | Not yet recruiting | University College, London | 800 | 2026-11-01 | 2026-08-28 |
| Efficacy Testing of a Multi-Level Family Planning Intervention Family Planning Intervention, Water, Sanitation, and Hygiene (WASH) Intervention - Unintended Pregnancy, Family Planning | Phase 2 / Phase 3 | Recruiting | Boston College | 1464 | 2025-06-12 | 2026-03-23 |
| Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2) zinc sulfate, Placebo - Sickle Cell Disease | Phase 2 / Phase 3 | Completed | Indiana University | 100 | 2025-02-10 | 2026-01-30 |
| Preventive Treatment Of Latent Tuberculosis Infection In People With Diabetes Mellitus Isoniazid and Rifapentine (INH-RPT), Placebo - Diabetes Mellitus, Tuberculosis | Phase 3 | Unknown | Dr. Nyanda Elias Ntinginya | 3000 | 2022-06-17 | 2023-03-29 |
| An Enhanced Package of Care to Reduce Reduce Mortality in Advanced HIV Disease Enhanced care package - The Study Will Focus on Assessing the Survival Benefit on an Enhanced Package of Care for Patients With Advanced HIV Disease | Phase 3 | Recruiting | Makerere University | 2400 | 2022-05-04 | 2022-07-12 |
| Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children Pancreatic Enzyme, Ursodeoxycholic acid, Pancreatic Enzyme placebo - SEPSIS, MALNUTRITION, CHILD | Phase 2 / Phase 3 | Unknown | University of Oxford | 400 | 2021-07-01 | 2023-02-24 |
| Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition Ceftriaxone Sodium, Ampicillin, Gentamicin - HIV-1-infection, Malnutrition, Child | Phase 2 / Phase 3 | Unknown | Makerere University | 300 | 2021-06-14 | 2021-09-30 |
| Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia Dihydroartemisinin Piperaquine - Sickle Cell Anemia in Children, Malaria | Phase 3 | Completed | Liverpool School of Tropical Medicine | 723 | 2021-04-09 | 2023-09-13 |
| Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II ) Hydroxyurea - Sickle Cell Anemia in Children | Phase 3 | Completed | Global Health Uganda LTD | 270 | 2021-03-09 | 2025-04-17 |
| Safety & Efficacy of Low Dose Aspirin / Ivermectin Combination Therapy for Treatment of Covid-19 Patients 3-dayIVM 200 mcg/kg/day/14-day 75mgASA/day + standard of care (intervention 1) - Covid19 | Phase 2 / Phase 3 | Unknown | Makerere University | 490 | 2021-02-19 | 2021-02-24 |
| Household-level Impact of IPT of Malaria in Schoolchildren IPT with Dihydroartemisinin Piperaquine - Malaria | Phase 3 | Unknown | Makerere University | 1500 | 2021-01-28 | 2021-02-24 |
| Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load Dose escalation - HIV/AIDS, Tuberculosis | Phase 2 / Phase 3 | Completed | University of Liverpool | 26 | 2020-10-30 | 2024-07-12 |
| Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes 100% Oxygen, 21% oxygen - Fetal Distress, Birth Asphyxia | Phase 3 | Unknown | Makerere University | 1108 | 2020-03-16 | 2020-03-26 |
| Empirical Treatment Against Cytomegalovirus and Tuberculosis in HIV-infected Infants With Severe Pneumonia Valganciclovir Oral Solution [Valcyte], Tuberculostatic Agents - Pneumonia, HIV/AIDS | Phase 2 / Phase 3 | Completed | Hospital Universitario 12 de Octubre | 563 | 2020-03-01 | 2025-09-19 |
| Nucleosides And Darunavir/Dolutegravir In Africa Darunavir, Ritonavir, Dolutegravir - Human Immunodeficiency Virus | Phase 3 | Unknown | Makerere University | 465 | 2019-07-30 | 2020-07-30 |
| Maternal Depression Treatment in HIV evidence-based depression treatment - Depression | Phase 2 / Phase 3 | Completed | RAND | 391 | 2019-07-08 | 2024-11-15 |
| Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia Single dose liposomal Amphotericin and Fluconazole, Fluconazole - Cryptococcal Meningitis | Phase 2 / Phase 3 | Recruiting | Makerere University | 356 | 2019-06-20 | 2026-04-28 |
| Preventing Stroke Triggers in Children With Sickle Cell Anaemia in Mulago Hospital, Kampala (PREST ): a Randomized Control Trial Influenza vaccine - Preventing Stroke in Sickle Cell Anaemia | Phase 2 / Phase 3 | Unknown | Makerere University | 150 | 2018-08-22 | 2018-09-12 |
| Detecting and Treating Subclinical Anthracycline Therapy Related Cardiac Dysfunction in Low Income Country. Carvedilol - Chemotherapy Related Cardiac Dysfunction | Phase 3 | Unknown | Makerere University | 50 | 2018-06-01 | 2018-05-31 |
| Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa Miltefosine, Paromomycin, Sodium stibogluconate - Visceral Leishmaniasis | Phase 3 | Completed | Drugs for Neglected Diseases | 439 | 2018-01-24 | 2024-02-29 |
Showing 20 of 48. Sign in to see all of them.
Malaria (13) · Acquired Immunodeficiency Syndrome (5) · Anemia, Sickle Cell (5) · HIV Infections (5) · Pneumonia (4) · Tuberculosis (4) · Anemia (2) · Child Nutrition Disorders (2) · Malaria, Cerebral (2) · Malnutrition (2) · Meningitis, Cryptococcal (2) · Asphyxia Neonatorum (1) · Breast Feeding (1) · COVID-19 (1) · Critical Illness (1)
Lamivudine (4) · Hydroxyurea (3) · dolutegravir (3) · Artemether, Lumefantrine Drug Combination (2) · Atorvastatin (2) · Ceftriaxone (2) · Darunavir (2) · Misoprostol (2) · Ritonavir (2) · Standard of Care (2) · Tenofovir (2) · Trimethoprim, Sulfamethoxazole Drug Combination (2) · Zidovudine (2) · abacavir (2) · Air (1)
Uganda (41) · Malawi (4) · Kenya (3) · Norway (2) · Bangladesh (1) · Côte d’Ivoire (1) · Ethiopia (1) · France (1) · Italy (1) · Mozambique (1) · Netherlands (1) · Republic of the Congo (1) · South Africa (1) · Spain (1) · Sudan (1)
James K Tumwine, PhD (2) · Joaniter I Nankabirwa, MSc CEB (2) · Ahmed M Musa, MD, Prof (1) · Amon Agaba, PhD (1) · Anthony Okoth, MMed (1) · Carolyn Nabasumba, M.B.Ch.B (1) · Chandy C John, M.D. (1) · Chandy C John, MD (1) · Chandy C. John, M.D. (1) · Christine Namata, MBChB (1) · Christopher C. Whalen, MD (1) · Christopher Ndugwa, PhD (1) · Cinta Moraleda, MD, PhD (1) · Cordelia M Katureebe, MBCHB (1) · Damalie Nakanjako, MD, PhD (1)
PMID 17958887, PMID 19852829, PMID 19877969, PMID 19948038, PMID 20525230, PMID 20569064, PMID 20683193, PMID 20858275, PMID 20889882, PMID 21383095, PMID 21454456, PMID 21600005, PMID 22316073, PMID 22453048, PMID 23151221, PMID 23273022, PMID 23382157, PMID 23447696, PMID 24059911, PMID 24468007, PMID 24610872, PMID 24621953, PMID 24825870, PMID 25369200, PMID 25433628, PMID 25441397, PMID 25514794, PMID 26285704, PMID 27280792, PMID 27339303, PMID 27401569, PMID 27840069, PMID 29051184, PMID 29996833, PMID 30029620, PMID 30256903, PMID 30325463, PMID 30345376, PMID 30400934, PMID 30567567, PMID 31135090, PMID 31242860, PMID 31277180, PMID 31345462, PMID 31539371, PMID 32579813, PMID 32843994, PMID 33264546, PMID 33346335, PMID 33677986
2019 (1), R01AI051219 (1), R01HD096559 (1), R01HD113806 (1), R01NS086312 (1)