6 recruiting, 1 completed, 1 not yet recruiting, 1 withdrawn. 7 Not applicable, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 5, Completed 1, Not yet recruiting 1 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 2 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LIFU Effects & Outcomes: Mechanisms Evaluating Striatal Systems Imaging (LEO MESSI) LIFU - Schizophrenia, Auditory Hallucinations | Not applicable | Not yet recruiting | University of California, San Francisco | 12 | 2027-02-01 | 2026-08-05 |
| Focused Ultrasound for Behavioral Health ATTN201 head-worn focused ultrasound - Depression, Anxiety | Not applicable | Recruiting | Attune Neurosciences Inc | 300 | 2026-10-19 | 2026-10-27 |
| CMN LIFU for Enhanced Glymphatic Clearance in Amyloid-Positive MCI ATTN201 Focused Ultrasound to the CMN, ATTN201 Unfocused Ultrasound - Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | University of California, San Francisco | 28 | 2026-10-01 | 2026-10-14 |
| Focused Ultrasound Stimulation for the Treatment of Chronic Pain ATTN201 focused ultrasound system - Chronic Pain | Not applicable | Recruiting | Attune Neurosciences Inc | 120 | 2026-09-04 | 2026-10-27 |
| SONATA LIFU for OCD Low Intensity Focused Ultrasound, Sham (No Treatment) - Obsessive Compulsive Disorder | Phase 2 | Recruiting | University of Pennsylvania | 40 | 2026-07-01 | 2026-07-27 |
| OCD LIFU Target Engagement Low Intensity Focused Ultrasound - Obsessive Compulsive Disorder (OCD) | Not applicable | Recruiting | University of Pennsylvania | 10 | 2026-03-04 | 2026-10-01 |
| tFUS to Enhance Alertness and Performance Transcranial Focused Ultrasound - Reaction Time, Alertness | Early Phase 1 | Withdrawn | Medical University of South Carolina | 2025-08-01 | 2025-09-08 | |
| Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy Target optimization using LIFU, Serial LIFU stimulation - Drug-Resistant Epilepsy, Epilepsy | Not applicable | Recruiting | University of California, San Francisco | 40 | 2025-07-09 | 2026-07-02 |
| Safety Assessment of Central Medial Thalamus Stimulation Using Transcranial Focused Ultrasound Transcranial Focused Ultrasound - Healthy | Not applicable | Completed | Medical University of South Carolina | 30 | 2023-05-15 | 2025-04-27 |
Obsessive-Compulsive Disorder (3) · Alzheimer Disease (1) · Anxiety Disorders (1) · Chronic Pain (1) · Cognitive Dysfunction (1) · Depression (1) · Drug Resistant Epilepsy (1) · Epilepsies, Partial (1) · Epilepsy (1) · Epilepsy, Generalized (1) · Hallucinations (1) · Schizophrenia (1) · Seizures (1)
United States (9)
Andrew Krystal, MD (1) · Joline M Fan, MD, MS (1) · Karuna Subramaniam, PhD (1) · Katherine Scangos, MD, PhD (1) · Keith Murphy, PhD (1)