11 completed, 2 recruiting, 2 terminated, 1 active not recruiting. 8 Not applicable, 3 Phase 3, 3 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 3, Recruiting 2, Active not recruiting 1, Not yet recruiting 1, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 2 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair Usual Care, Pulmonary Vein Isolation - Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Atrial Fibrillation Network | 956 | 2026-09-01 | 2026-09-10 |
| PULSed Field Ablation for Atrial Fibrillation Using a Balloon for Early Intervention - Study Ablation of atrial fibrillation (AF) - Atrial Fibrillation | Not applicable | Recruiting | Asklepios proresearch | 264 | 2026-08-19 | 2026-10-06 |
| Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11) Early atrial fibrillation ablation, Usual Care - Atrial Fibrillation | Not applicable | Recruiting | Atrial Fibrillation Network | 2312 | 2024-10-14 | 2026-01-08 |
| Clinical Cohorts for Validation of New Digital Biomarkers Atrial Fibrillation, Atrial Cardiomyopathy | Completed | Atrial Fibrillation Network | 515 | 2023-03-02 | 2026-10-21 | |
| From the Emergency Department Directly to Ablation of Atrial Fibrillation Study Ablation of atrial fibrillation (AF) - Atrial Fibrillation (AF) | Not applicable | Active not recruiting | Asklepios proresearch | 350 | 2021-12-15 | 2026-10-20 |
| The Smartphone and Wearable Detected Atrial Arrhythmia in Older Adults Case Finding Study (Smart in OAC - AFNET 9) Preventicus heartbeat app in combination with wearables - Atrial Arrhythmia | Not applicable | Completed | Atrial Fibrillation Network | 882 | 2021-01-26 | 2022-07-07 |
| Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy CE-mark approved LAA closure devices, Acetylsalicylic acid, Clopidogrel - Atrial Fibrillation | Phase 4 | Completed | Charite University, Berlin, Germany | 912 | 2018-02-28 | 2025-12-12 |
| Compare Apixaban and Vitamin-K Antagonists in Patients With Atrial Fibrillation (AF) and End-Stage Kidney Disease (ESKD) Apixaban, Phenprocoumon - Atrial Fibrillation, End-stage Kidney Disease | Phase 3 | Completed | Atrial Fibrillation Network | 108 | 2017-06-20 | 2022-09-27 |
| Non-vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes Edoxaban, ASA - Atrial High Rate Episodes | Phase 3 | Terminated | Atrial Fibrillation Network | 2608 | 2016-02-01 | 2025-02-06 |
| Apixaban During Atrial Fibrillation Catheter Ablation: Comparison to Vitamin K Antagonist Therapy Vitamin K antagonist, Apixaban - Atrial Fibrillation | Phase 4 | Completed | Atrial Fibrillation Network | 676 | 2014-12-01 | 2017-10-20 |
| Resolution of Left Atrial-Appendage Thrombus - Effects of Dabigatran in Patients With AF Dabigatran etexilate, Phenprocoumon - Atrial Fibrillation or Atrial Flutter, Thrombosis of Left Atrial Appendage | Phase 2 | Terminated | Johannes Gutenberg University Mainz | 64 | 2014-07-01 | 2019-07-26 |
| Early Treatment of Atrial Fibrillation for Stroke Prevention Trial early standardised rhythm control - Atrial Fibrillation, Stroke | Phase 4 | Completed | Atrial Fibrillation Network | 2789 | 2011-07-01 | 2020-07-23 |
| KONVERT-AF - Relevance of Point in Time for Conversion of Acute Atrial Fibrillation external electrical cardioversion - Atrial Fibrillation | Not applicable | Withdrawn | Atrial Fibrillation Network | 2006-09-01 | 2012-09-03 | |
| Randomized Trial of Two Different Strategies to Treat Paroxysmal Atrial Fibrillation Pulmonary vein ablation - Atrial Fibrillation | Not applicable | Completed | Atrial Fibrillation Network | 232 | 2006-02-01 | 2012-09-10 |
| Flecainide-Short Long Study (Flec-SL) Flecainide - Atrial Fibrillation | Not applicable | Completed | Atrial Fibrillation Network | 760 | 2005-03-01 | 2012-09-11 |
| Trial to Investigate the Efficacy of Olmesartan in Paroxysmal Atrial Fibrillation Olmesartan - Heart Disease, Arrhythmia | Phase 3 | Completed | Atrial Fibrillation Network | 422 | 2005-01-01 | 2012-09-11 |
| Recurrence of Atrial Fibrillation in Patients With Dual-chamber Pacemakers and Drug Therapy Atrial Fibrillation | Completed | Atrial Fibrillation Network | 263 | 2005-01-01 | 2012-09-10 | |
| Prospective Registration and Assessment of Serious Adverse Events Within the AFNET Atrial Fibrillation, Assessment of Serious Advers Events | Completed | Atrial Fibrillation Network | 13000 | 2004-02-01 | 2020-09-22 |
Atrial Fibrillation (17) · Stroke (3) · Arrhythmias, Cardiac (1) · Atrial Flutter (1) · Gastroesophageal Reflux (1) · Heart Diseases (1) · Heart Failure (1) · Kidney Diseases (1) · Kidney Failure, Chronic (1) · Mitral Valve Insufficiency (1) · Syncope (1)
Phenprocoumon (4) · apixaban (3) · Dabigatran (2) · Warfarin (2) · edoxaban (2) · Aspirin (1) · Clopidogrel (1) · Flecainide (1) · Rivaroxaban (1) · acarboxyprothrombin (1) · fluindione (1) · olmesartan (1)
Germany (16) · Spain (5) · Netherlands (4) · Poland (4) · United Kingdom (4) · Belgium (3) · Denmark (3) · Italy (3) · Austria (2) · Czechia (2) · France (2) · Australia (1) · Bulgaria (1) · Canada (1) · Greece (1)
Stephan Willems, MD (3) · Paulus Kirchhof, Prof. Dr. (2) · Andreas Goette, MD (1) · Andreas Rillig, PD Dr. (1) · Andreas Schuchert, Prof. Dr. (1) · Antonia Zapf, Prof. Dr. (1) · Arian Sultan, MD (1) · Daniel Steven, MD (1) · G Breithardt, Prof (1) · Holger Reinecke, Prof. Dr. (1) · Jason Andrade, Prof. Dr. (1) · Karl-Heinz Kuck, MD (1) · Kevin Vernooy, Prof. Dr. (1)
PMID 34447995, PMID 41766700, PMID 12860855, PMID 20958836, PMID 22157519, PMID 22713626, PMID 23577826, PMID 23871349, PMID 24016492, PMID 24016511, PMID 24134539, PMID 24351885, PMID 24665920, PMID 25643988, PMID 26763226, PMID 27042964, PMID 27516462, PMID 27567408, PMID 27742775, PMID 28201538, PMID 28506916, PMID 28751544, PMID 28964382, PMID 29300976, PMID 30206088, PMID 30342299, PMID 30821012, PMID 30874766, PMID 31431051, PMID 31510841, PMID 32107811, PMID 32632547, PMID 32725107, PMID 32865375, PMID 33197158, PMID 33197159, PMID 34328366, PMID 34978360, PMID 35135308, PMID 35387433, PMID 35550691, PMID 35863844, PMID 35968706, PMID 36036648, PMID 36335915, PMID 36517170, PMID 36710894, PMID 36813380, PMID 37264683, PMID 37622677
2014 (1), 2015 (1)