280 completed, 54 unknown, 33 terminated, 17 recruiting. 187 Not applicable, 95 Phase 2, 55 Phase 4, 51 Phase 3, 27 Phase 1.
Follow Vitamin D3: new trials by email Literature Review of Vitamin D3 trials Research Report on Vitamin D3
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular Cancer Biospecimen Collection, Cholecalciferol, Computed Tomography - Advanced Hepatocellular Carcinoma, Advanced Melanoma | Phase 2 | Not yet recruiting | University of Southern California | 46 | 2026-11-01 | 2026-09-23 |
| Supplementation Absorption Comparison Aquacelle® Omega 3, Comparator Omega 3, Plexosome® Vitamin D3 - Healthy Volunteer | Phase 4 | Recruiting | RDC Clinical Pty Ltd | 160 | 2026-08-31 | 2026-09-10 |
| Effects of Cofrogliptin on Beta-Cell Function in LADA Patients Cofrogliptin, Vitamin D3, Metformin - Latent Autoimmune Diabetes in Adults (LADA) | Not applicable | Not yet recruiting | Second Xiangya Hospital of Central South University | 84 | 2026-05-15 | 2026-05-08 |
| Vitamin D Treat-to-Target Strategy for Children With Overactive Bladder-Wet urotherapy, Solifenacin Succinate, Vitamin D3 - Urinary Bladder, Overactive, Overactive Bladder | Not applicable | Recruiting | Children's Hospital of Chongqing Medical University | 180 | 2026-04-20 | 2026-04-17 |
| Effect of Vitamin D on Postoperative Pain in Symptomatic Irreversible Pulpitis Vitamin D3, Placebo - Pulpitis - Irreversible, Vitamin D Deficiency | Not applicable | Active not recruiting | Future University in Egypt | 54 | 2025-11-01 | 2026-05-12 |
| Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) Vitamin D3 - Osteoarthritis, Vitamin D Deficiency | Phase 4 | Active not recruiting | University of Miami | 200 | 2025-09-08 | 2026-09-23 |
| Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients Vitamin D3 - Ulcerative Colitis (UC) | Not applicable | Recruiting | University of Veterinary and Animal Sciences, Lahore - Pakistan | 60 | 2025-09-02 | 2025-12-17 |
| Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D Vitamin D3 - Epilepsy, Hypovitaminosis D | Not applicable | Recruiting | Bangladesh Medical University | 15 | 2025-07-19 | 2025-07-31 |
| ICOPE INTENSE-K Pilot Study ICOPE intense intervention, Ketone Ester (KE) supplementation, Placebo - Ageing | Not applicable | Recruiting | University Hospital, Toulouse | 40 | 2025-07-09 | 2025-07-23 |
| Vitamin D3 Supplementation in Patients With HIV: Effects on Interleukin-6 Levels and CD4 Counts Vitamin D3, Antiretroviral (ARV) medications - Human Immunodeficiency Virus (HIV) | Not applicable | Completed | Universitas Sebelas Maret | 20 | 2025-06-01 | 2026-07-15 |
| Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Glycemic Control and Cardiovascular Disease Risk in Patients With Type 2 Diabetes Vitamin D3, yeast β-glucan, Vitamin D placebo - Diabetes Mellitus, Type 2 | Not applicable | Recruiting | Huazhong University of Science and Technology | 2500 | 2025-04-08 | 2026-02-02 |
| Vitamin D to Improve Quadricep Muscle Strength Vitamin D3, Placebo - Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy | Phase 2 | Recruiting | Chinese University of Hong Kong | 60 | 2025-03-17 | 2025-03-18 |
| Effects of Vitamin D and Prebiotic Supplementation on Glucose Control During Pregnancy Vitamin D3, Prebiotics, Prebiotics placebo - Glucose Intolerance During Pregnancy | Not applicable | Recruiting | Huazhong University of Science and Technology | 500 | 2025-02-24 | 2025-09-16 |
| Effects of Vitamin D and Calcium on Hyperglycemia and Dyslipidemia in Patients Gestational Diabetes vitamin D3 - Diabetes Mellitus, Gestational | Not applicable | Completed | Riphah International University | 60 | 2025-01-28 | 2026-03-17 |
| Effect of Preoperative Vitamin D Supplementation in Liver Transplant Recipients With Vitamin D Deficiency on Post Transplant Outcomes Vitamin D3, Placebo - Post Liver Transplant Infection | Not applicable | Completed | Institute of Liver and Biliary Sciences, India | 140 | 2024-12-30 | 2026-08-06 |
| Efficacy and Safety of Vitamin D Supplementation Combined With Alarm Therapy in Treating Nocturnal Enuresis alarm therapy, Vitamin D3 - Enuresis | Not applicable | Completed | Xing Liu | 262 | 2024-12-01 | 2026-02-23 |
| Vitamin D3 Supplementation Regimens and Preeclampsia Risk Vitamin D3 - Preeclampsia | Not applicable | Recruiting | Sana'a University | 268 | 2024-08-04 | 2026-06-15 |
| Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis Placebo, Cholecalciferol - Critically Ill, Sepsis | Not applicable | Not yet recruiting | Chimei Medical Center | 240 | 2024-07-01 | 2024-06-17 |
| High-Dose Vitamin D3 for Diabetic Foot Ulcer Healing: Randomized Controlled Trial Vitamin D3, Placebo - Diabetic Foot Ulcer, Vitamin D Deficiency | Not applicable | Completed | Universitas Sriwijaya | 24 | 2024-07-01 | 2025-08-24 |
| Vitamin A and D Supplementation in Allogeneic HCT Vitamin A, Vitamin D3 - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | St. Petersburg State Pavlov Medical University | 220 | 2024-05-15 | 2024-07-31 |
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Vitamin D Deficiency (110) · Cardiovascular Diseases (15) · Insulin Resistance (15) · Diabetes Mellitus, Type 2 (14) · Osteoporosis (14) · Obesity (13) · Breast Neoplasms (12) · COVID-19 (12) · Diabetes Mellitus (12) · Bone Diseases, Metabolic (10) · Crohn Disease (10) · Critical Illness (9) · Inflammation (9) · Prostatic Neoplasms (9) · Asthma (8)
Brigham and Women's Hospital (16) · Medical University of South Carolina (9) · Mayo Clinic (8) · Merck Sharp & Dohme LLC (8) · Columbia University (6) · Creighton University (6) · Emory University (6) · Massachusetts General Hospital (6) · Tufts University (6) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (5) · Roswell Park Cancer Institute (5) · University of Nebraska (5) · Boston Children's Hospital (4) · Case Comprehensive Cancer Center (4) · Johns Hopkins University (4)
United States (190) · Canada (21) · China (16) · Egypt (12) · United Kingdom (12) · Bangladesh (10) · Pakistan (9) · Denmark (7) · Finland (7) · Austria (6) · Indonesia (6) · Saudi Arabia (6) · Switzerland (6) · Germany (5) · Mexico (5)
Sebastiano Gattoni-Celli, MD (4) · An Pan, PHD (3) · Arturo Borzutzky, M.D. (3) · Meryl S LeBoff, M.D. (3) · Rehab Khalil (3) · Abdullah Baqui, MBBS (2) · Bess Dawson-Hughes, M.D. (2) · Bess Dawson-Hughes, MD (2) · Ellen M Mowry, MD, MCR (2) · Gang Liu, PHD (2) · Gilbert R Kaats, PhD FACN (2) · Harry G Preuss, MD MACN (2) · J C Gallagher, MD (2) · Joseph B Muhlestein, MD (2)
PMID 33305842, PMID 39077939, PMID 33513226, PMID 34853363, PMID 21706518, PMID 29526608, PMID 31699704, PMID 32492153, PMID 32749491, PMID 33724323, PMID 34932079, PMID 35018442, PMID 35082139, PMID 37212116, PMID 37267732, PMID 37454148, PMID 37952113, PMID 38272846, PMID 11146455, PMID 11158062, PMID 11181474, PMID 12865912, PMID 15175591, PMID 15470215, PMID 15749627, PMID 15897380, PMID 15987315, PMID 16895558, PMID 17130571, PMID 17202417, PMID 17927502, PMID 18092326, PMID 18541589, PMID 18711029, PMID 18771564, PMID 18991184, PMID 19091317, PMID 19258546, PMID 19443628, PMID 19480654, PMID 19696220, PMID 19861511, PMID 19874198, PMID 19918922, PMID 20056649, PMID 20056760, PMID 20202055, PMID 20332274, PMID 20427729, PMID 20516268
2009 (4), 2019 (2), P30CA016056 (2), P50CA090440 (2), R01AR059775 (2), R01AR060574 (2), R01CA138962 (2), U01CA138962 (2), 2008 (1), 2014 (1), K23AR056736 (1), K23DK076979 (1), K23NS087151 (1), N01CN35153 (1), N01CN35158 (1)