14 recruiting. 14 Phase 2, 4 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Recruiting 14 |
| Phase 1 | 4 | Recruiting 4 |
| Phase 3 | 2 | Recruiting 2 |
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics - Prosthetic Joint Infection (PJI) | Phase 2 | Recruiting | TenNor Therapeutics (Zhongshan) Limited | 40 | 2026-10-21 | 2026-10-28 |
| Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study) MGT-006, Vancomycin hydrochloride, Amoxicillin hydrate/ Fosfomycin calcium hydrate/ Metronidazole - Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate | Phase 1 / Phase 2 | Recruiting | Metagen Therapeutics, Inc. | 54 | 2026-07-09 | 2026-11-03 |
| Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Placebo (blinded), Vancomycin (blinded), Vancomycin (open-label extension) - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | McMaster University | 14 | 2026-06-17 | 2026-10-09 |
| Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mg, Inulin/Inulin C13 - IBD, Crohn Disease | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 45 | 2026-01-02 | 2026-03-12 |
| Evaluation of Microbiota Transplant Therapy in Patients With Alopecia Areata Vancomycin, Neomycin and MTT capsules, Placebo capsules - Alopecia Areata, Alopecia Totalis | Phase 2 | Recruiting | University of Minnesota | 40 | 2025-08-21 | 2026-06-26 |
| Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II) VE818, Placebo, Oral Vancomycin - Environmental Enteric Dysfunction (EED) | Phase 2 | Recruiting | University Ghent | 144 | 2025-07-30 | 2025-11-17 |
| Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) Fecal microbiota transfer, Vancomycin Oral Capsule, Atezolizumab + Bevacizumab - Immunotherapy, HCC - Hepatocellular Carcinoma | Phase 2 | Recruiting | Michael Dill | 48 | 2025-07-16 | 2025-08-06 |
| A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV) - Periprosthetic Joint Infection (PJI) | Phase 1 / Phase 2 | Recruiting | TenNor Therapeutics Inc. | 33 | 2025-04-03 | 2026-10-19 |
| Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients Vancomycin 125mg, Placebo - Clostridium Difficile Infection, Vancomycin Resistant Enterococci Infection | Phase 2 / Phase 3 | Recruiting | Riverside University Health System Medical Center | 176 | 2024-10-21 | 2025-11-10 |
| Combination Study of Antibiotics With Enzalutamide (PROMIZE) Enzalutamide 40mg, Amoxicillin 500mg, Metronidazole 400mg - Metastatic Castration-Resistant Prostate Cancer (mCRPC) | Phase 1 / Phase 2 | Recruiting | Institute of Cancer Research, United Kingdom | 39 | 2023-11-02 | 2025-11-24 |
| Vancomycin in Primary Sclerosing Cholangitis in Italy Oral Vancomycin, Placebo - Primary Sclerosing Cholangitis, Liver and Intrahepatic Bile Duct Disorder | Phase 2 | Recruiting | University of Milano Bicocca | 84 | 2023-06-15 | 2025-07-25 |
| The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection Vancomycin - Postoperative Complications | Phase 2 / Phase 3 | Recruiting | Women and Infants Hospital of Rhode Island | 30 | 2022-10-25 | 2023-12-05 |
| Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement. Vancomycin + Tobramycin, Saline - Arthroplasty, Replacement, Hip, Osteoarthritis, Hip | Phase 2 | Recruiting | University Hospital, Linkoeping | 1100 | 2022-04-01 | 2026-07-10 |
| VE416 for Treatment of Food Allergy Vancomycin plus VE416 before PNOIT, Vancomycin plus VE416 with PNOIT, Placebo plus VE416 with PNOIT - Peanut Allergy | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 60 | 2019-06-28 | 2023-10-18 |
Colitis, Ulcerative (3) · Cholangitis, Sclerosing (2) · Alopecia Areata (1) · Alopecia universalis (1) · Carcinoma, Hepatocellular (1) · Clostridium Infections (1) · Crohn Disease (1) · Digestive System Diseases (1) · Inflammatory Bowel Diseases (1) · Osteoarthritis, Hip (1) · Peanut Hypersensitivity (1) · Postoperative Complications (1)
Assistance Publique - Hôpitaux de Paris (1) · Institute of Cancer Research, United Kingdom (1) · Massachusetts General Hospital (1) · McMaster University (1) · Metagen Therapeutics, Inc. (1) · Michael Dill (1) · Riverside University Health System Medical Center (1) · TenNor Therapeutics (Zhongshan) Limited (1) · TenNor Therapeutics Inc. (1) · University Ghent (1) · University Hospital, Linkoeping (1) · University of Milano Bicocca (1) · University of Minnesota (1) · Women and Infants Hospital of Rhode Island (1)
United States (5) · China (2) · Burkina Faso (1) · Canada (1) · France (1) · Germany (1) · Italy (1) · Japan (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Carl Lachat, M.Eng., Ph.D. (1) · Jessica DiSilvestro, MD (1) · Johann De Bono, MD (1) · Maria K Hordinsky, MD (1) · Michael T Dill, PhD (1) · Neeraj Narula, MD (1) · Wayne G Shreffler, MD, PhD (1)
PMID 33463542, PMID 40487852, PMID 40930564, PMID 41513411, PMID 42731828