26 completed, 6 recruiting, 3 active not recruiting, 3 terminated. 42 Phase 2, 3 Phase 1, 1 Phase 3.
Follow Valacyclovir: new trials by email Literature Review of Valacyclovir trials Research Report on Valacyclovir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Compare GS-1179 Versus Valacyclovir in HSV-2 Seropositive Participants With Recurrent Genital Herpes GS-1179, GS-1179 PTM, Valacyclovir - HSV-2 Infection | Phase 2 | Not yet recruiting | Gilead Sciences | 300 | 2026-11-01 | 2026-11-03 |
| SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Valacyclovir, Celecoxib, Paxlovid - Post-acute Sequelae of COVID-19, Long COVID | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-10-20 | 2026-10-28 |
| Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma TGX-007, Valaciclovir - Glioblastoma (GBM), High Grade Gliomas | Phase 1 / Phase 2 | Recruiting | Trogenix ltd | 68 | 2026-04-21 | 2026-10-23 |
| A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene Besadenovec aglatimagene besadenovec + valacyclovir, External Beam Radiation Therapy (EBRT) - Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Candel Therapeutics, Inc. | 45 | 2025-10-30 | 2026-09-15 |
| Valacyclovir in Pain Management of Acute Apical Abscesses Valacyclovir 500 MG, Placebo - Acute Apical Abscess, Pain, Acute | Phase 2 | Recruiting | University of California, San Francisco | 60 | 2023-10-25 | 2025-05-30 |
| Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) Pirtobrutinib, Obinutuzumab, Venetoclax - Leukemia | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 60 | 2022-12-20 | 2026-04-30 |
| A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster Peginterferon α1b, Peginterferon α1b with valacyclovir, Valacyclovir - Herpes Zoster | Phase 2 | Completed | Shanghai Institute Of Biological Products | 50 | 2022-10-11 | 2023-12-29 |
| Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy Valacyclovir, Placebo - Oral Mucositis, Head and Neck Cancer (H&N) | Phase 2 | Enrolling by invitation | Instituto Oncoclinicas | 84 | 2022-09-05 | 2026-01-23 |
| Valacyclovir for Mild Cognitive Impairment Valacyclovir hydrochloride 500mg caplet, Placebo sugar pill caplet - Mild Cognitive Impairment, Herpes Simplex 1 | Phase 2 | Completed | New York State Psychiatric Institute | 50 | 2021-02-01 | 2026-03-31 |
| CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Aglatimagene besadenovec, Valacyclovir, Standard of Care anti-PD-1/PD-L1 (ICI) - Non Small Cell Lung Cancer | Phase 2 | Active not recruiting | Candel Therapeutics, Inc. | 90 | 2020-10-13 | 2026-11-05 |
| Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 2 Infection HDIT101, Valaciclovir, HDIT101 placebo - Herpes Genitalis | Phase 2 | Completed | Heidelberg ImmunoTherapeutics GmbH | 122 | 2019-11-15 | 2022-01-18 |
| Epstein-Barr Virus Suppression in Chronic Obstructive Pulmonary Disease (EViSCO): a Phase 2 Randomised Control Trial Valaciclovir, Placebo capsules (containing Avicel blend) - COPD, EBV | Phase 2 | Terminated | Belfast Health and Social Care Trust | 85 | 2018-10-11 | 2020-09-30 |
| Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery HSV-Tk, Valacyclovir, Bicalutamide - High-risk Prostate Cancer, Prostate Cancer | Phase 2 | Recruiting | The Methodist Hospital Research Institute | 60 | 2018-08-02 | 2021-04-06 |
| Anti-viral Therapy in Alzheimer's Disease Valacyclovir, Placebo - Alzheimer Disease, Herpes Simplex 1 | Phase 2 | Completed | Columbia University | 120 | 2018-02-12 | 2025-09-25 |
| SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC ADV/HSV-tk, Valacyclovir, SBRT - Metastatic Non-small Cell Lung Cancer, Metastatic Triple-negative Breast Cancer | Phase 2 | Completed | The Methodist Hospital Research Institute | 57 | 2017-07-01 | 2024-10-15 |
| Trial of Radiation and Gene Therapy Before Nivolumab for Metastatic Non-Small Cell Lung Carcinoma and Uveal Melanoma ADV/HSV-tk, Valacyclovir, SBRT - Lung Squamous Cell Carcinoma Stage IV, Nonsquamous Nonsmall Cell Neoplasm of Lung | Phase 2 | Terminated | Eric Bernicker, MD | 11 | 2017-02-15 | 2023-09-21 |
| Feasibility and Effects of Valaciclovir Treatment in Persons With Early Alzheimer's Disease Valaciclovir 500Mg Tablet - Alzheimer Disease, Mild Cognitive Impairment | Phase 2 | Completed | Hugo Lovheim | 33 | 2016-12-01 | 2020-04-03 |
| Should We Use Oral Valacyclovir in Acute Herpetic Gingivostomatitis in Children? Valacyclovir, placebo - Herpetic Gingivostomatitis | Phase 2 | Completed | St. Justine's Hospital | 80 | 2016-07-01 | 2023-04-11 |
| Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES) aglatimagene besadenovec, placebo, valacyclovir - Prostate Cancer | Phase 2 | Active not recruiting | Candel Therapeutics, Inc. | 187 | 2016-05-01 | 2026-10-02 |
| Valacyclovir to Prevent Vertical Transmission of Cytomegalovirus After Maternal Primary Infection During Pregnancy Valacyclovir, Placebo - Congenital Cytomegalovirus Infection | Phase 2 / Phase 3 | Completed | Rabin Medical Center | 100 | 2015-11-01 | 2019-07-16 |
Showing 20 of 42. Sign in to see all of them.
Herpes Zoster (5) · Herpes Genitalis (4) · Prostatic Neoplasms (4) · Cytomegalovirus Infections (3) · Psychotic Disorders (3) · Schizophrenia (3) · Alzheimer Disease (2) · Bipolar Disorder (2) · Carcinoma, Non-Small-Cell Lung (2) · Cognitive Dysfunction (2) · Epstein-Barr Virus Infections (2) · Glioblastoma (2) · HIV Infections (2) · Herpes Simplex (2) · Leukemia (2)
Candel Therapeutics, Inc. (4) · M.D. Anderson Cancer Center (3) · The Methodist Hospital Research Institute (3) · Astellas Pharma Inc (2) · University of Minnesota (2) · AiCuris Anti-infective Cures AG (1) · Baylor College of Medicine (1) · Belfast Health and Social Care Trust (1) · Bristol-Myers Squibb (1) · Columbia University (1) · Epiphany Biosciences (1) · Eric Bernicker, MD (1) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Gilead Sciences (1) · Heidelberg ImmunoTherapeutics GmbH (1)
United States (26) · United Kingdom (4) · Canada (2) · Brazil (1) · Burkina Faso (1) · China (1) · Germany (1) · Israel (1) · Japan (1) · Kenya (1) · Mexico (1) · Netherlands (1) · Sweden (1)
Davangere Devanand, MD (2) · Carey Farquhar, MD, MPH (1) · David Putrino, PhD (1) · E. Antonio Chiocca, MD, PhD (1) · E. Brian Butler, MD (1) · Edward B Butler, MD (1) · Eric Bernicker, M.D. (1) · Hank Balfour, MD (1) · Henry H Balfour, MD (1) · Jennifer L Payne, MD (1) · Jenny Chang, MD (1) · Joe Kidney, MB, MD (1)
PMID 16044019, PMID 17314338, PMID 17617198, PMID 18039954, PMID 18593294, PMID 18596069, PMID 19469706, PMID 22147786, PMID 22446565, PMID 22509337, PMID 22711350, PMID 22852760, PMID 24504006, PMID 26312852, PMID 26843484, PMID 27450392, PMID 27943311, PMID 27997653, PMID 28437539, PMID 30102389, PMID 32034019, PMID 32919517, PMID 37011709, PMID 41109488, PMID 41405855, PMID 42805763
2016 (1), R01AG055422 (1), R03HD057773 (1)