22 completed, 3 unknown, 2 recruiting, 1 active not recruiting. 30 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 30 | Completed 22, Unknown 3, Recruiting 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
Follow Valacyclovir: new trials by email Literature Review of Valacyclovir trials Research Report on Valacyclovir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors Ad-hCMV-Flt3L, Ad-hCMV-TK, Biospecimen Collection - Recurrent Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Malignant Brain Neoplasm | Phase 1 | Recruiting | University of Michigan Rogel Cancer Center | 11 | 2026-05-22 | 2026-06-15 |
| Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma TGX-007, Valaciclovir - Glioblastoma (GBM), High Grade Gliomas | Phase 1 / Phase 2 | Recruiting | Trogenix ltd | 68 | 2026-04-21 | 2026-10-23 |
| A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis BD111 Injection (Investigative New Drug), Triple-drugs therapy of HSV-1 stromal keratitis - Herpes Simplex Virus Type I Stromal Keratitis | Phase 1 | Active not recruiting | Shanghai BDgene Co., Ltd. | 16 | 2023-09-04 | 2025-05-18 |
| Neonatal Phase 1 Valacyclovir Study Valacyclovir - Herpes Simplex | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 17 | 2023-08-07 | 2026-07-23 |
| Using Oral Valacyclovir to Treat Patients With Refractory IC/BPS Valacyclovir - Pain, Chronic, Urge Incontinence | Phase 1 | Unknown | Buddhist Tzu Chi General Hospital | 30 | 2021-07-01 | 2021-10-26 |
| Valacyclovir in Neonatal Herpes Simplex Virus Disease Valacyclovir - Neonatal Herpes Simplex Infection | Phase 1 | Completed | University of Alabama at Birmingham | 7 | 2021-07-01 | 2025-06-24 |
| GMCI, Nivolumab, and Radiation Therapy in Treating Patients With Newly Diagnosed High-Grade Gliomas AdV-tk, Valacyclovir, Radiation - Glioma, Malignant | Phase 1 | Completed | Candel Therapeutics, Inc. | 41 | 2018-02-27 | 2025-02-14 |
| Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer CAN-2409 + valacyclovir - Lung Cancer | Phase 1 | Completed | Candel Therapeutics, Inc. | 12 | 2017-05-04 | 2025-07-11 |
| HSV529 Vaccine in HSV-2 Seropositive Adults HSV529, Valacyclovir - Herpes Simplex Virus 2 | Phase 1 | Completed | Fred Hutchinson Cancer Center | 10 | 2015-11-01 | 2019-01-14 |
| Bioequivalence Study in Healthy Volunteers of a New Paediatric Formulation of Valacyclovir valacyclovir tablet, valacyclovir oral solution - Varicella Zoster Virus Infection, Herpes Simplex Virus Infection | Phase 1 | Completed | Radboud University Medical Center | 16 | 2013-12-01 | 2020-12-08 |
| Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion AdV-tk + valacyclovir - Malignant Pleural Effusion, Lung Cancer | Phase 1 | Completed | Candel Therapeutics, Inc. | 19 | 2013-10-01 | 2023-08-25 |
| Evaluating Three Grams Daily Valacyclovir in Patients With Chronic Hepatitis C and HSV-2 Infection (Phase I) Valacyclovir, Placebo - Chronic Hepatitis C Infection | Phase 1 | Completed | VA Office of Research and Development | 31 | 2011-11-01 | 2016-11-22 |
| A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors AdV-tk, valacyclovir, Radiation - Malignant Glioma, Recurrent Ependymoma | Phase 1 | Completed | Candel Therapeutics, Inc. | 8 | 2010-10-01 | 2023-08-25 |
| Herpes Simplex Type 2 Co-infection in Veterans With Chronic Hepatitis C Valacyclovir - Hepatitis C Virus Infection, Infection | Phase 1 | Unknown | G.V. (Sonny) Montgomery VA Medical Center | 50 | 2010-04-01 | 2011-11-07 |
| Study Comparing the Safety of ASP2151 to Valacyclovir and Placebo in Healthy Volunteers ASP2151, Valacyclovir, Placebo - Safety of ASP2151 | Phase 1 | Terminated | Astellas Pharma Inc | 442 | 2009-03-01 | 2013-02-28 |
| AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01) AdV-tk, Valacyclovir - Pancreatic Adenocarcinoma, Pancreatic Cancer | Phase 1 | Completed | Candel Therapeutics, Inc. | 27 | 2008-08-01 | 2023-08-25 |
| Bioavailability Study of Valacycovir HCl Tablets, 1000 mg of Dr. Reddy's Under Fed Condition Valacyclovir Hydrochloride - Healthy | Phase 1 | Completed | Dr. Reddy's Laboratories Limited | 34 | 2007-02-01 | 2010-06-14 |
| Pharmacokinetic Interaction Study of Steady-state Tipranavir/Ritonavir (TPV/r) With Single-dose Valaciclovir (VAL) in Healthy Volunteers Tipranavir, Ritonavir, Valaciclovir - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 29 | 2007-02-01 | 2014-08-27 |
| Bioavailability Study of Valacyclovir HCl Tablets, 1000 mg of Dr. Reddy's Under Fasting Conditions Valacyclovir Hydrochloride - Healthy | Phase 1 | Completed | Dr. Reddy's Laboratories Limited | 41 | 2007-02-01 | 2010-06-14 |
| 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers valacyclovir hydrochloride, placebo, valacyclovir plus aspirin - Herpes Simplex | Phase 1 | Unknown | National Eye Institute (NEI) | 60 | 2006-04-01 | 2008-01-07 |
Showing 20 of 30. Sign in to see all of them.
Herpes Simplex (5) · Glioblastoma (4) · Glioma (3) · Astrocytoma (2) · Hepatitis C (2) · Herpes Zoster (2) · Lung Neoplasms (2) · AIDS-Related Complex (1) · AIDS-Related Opportunistic Infections (1) · Acquired Immunodeficiency Syndrome (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Chickenpox (1) · Chronic Pain (1) · Disease (1)
Candel Therapeutics, Inc. (6) · Mylan Pharmaceuticals Inc (3) · Dr. Reddy's Laboratories Limited (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Teva Pharmaceuticals USA (2) · Astellas Pharma Inc (1) · Baylor College of Medicine (1) · Boehringer Ingelheim (1) · Buddhist Tzu Chi General Hospital (1) · Fred Hutchinson Cancer Center (1) · G.V. (Sonny) Montgomery VA Medical Center (1) · GlaxoSmithKline (1) · National Eye Institute (NEI) (1) · Radboud University Medical Center (1) · Shanghai BDgene Co., Ltd. (1)
United States (22) · India (2) · Canada (1) · Chile (1) · China (1) · Netherlands (1) · South Africa (1) · Taiwan (1) · United Kingdom (1)
Dorian Williams, M.D. (3) · Dr. Dharmesh Domadia, MD (2) · Andrea T Franson (1) · Bas Schouwenberg, MD (1) · Benoit Girard, MD (1) · Bryson Y (1) · Charu Aggarwal, MD (1) · Christine Johnston, MD, MPH (1) · E. Antonio Chiocca, MD, PhD (1) · Gershon A (1) · Henry H Balfour, MD (1) · Herbert E Kaufman, MD (1) · James D Carlson, Pharm. D (1) · Keller MA (1)
PMID 21844505, PMID 25795132, PMID 27162003, PMID 29550074, PMID 30883662, PMID 33160076, PMID 38540138, PMID 39133650, PMID 40120123
2009 (1), U54AI150225 (1), UM1CA137443 (1)