13 completed, 1 active not recruiting, 1 not yet recruiting, 1 recruiting. 17 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 13, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 1 | 4 | Completed 3, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Triiodothyronine: new trials by email Literature Review of Triiodothyronine trials Research Report on Triiodothyronine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| T4/T3 Therapy in Hypothyroidism Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo - Hypothyroidism Primary | Phase 2 | Not yet recruiting | University of Pennsylvania | 60 | 2026-11-01 | 2026-08-20 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| Thyroid Hormone Supplementation in Patients With Septic Shock triiodothyronine - Euthyroid Sick Syndromes, Septic Shock | Phase 2 | Completed | Cantonal Hospital Zenica | 108 | 2022-05-01 | 2023-09-28 |
| 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Irinotecan, Temozolomide, Bevacizumab - Recurrent Medulloblastoma, Recurrent Ependymoma | Phase 2 | Active not recruiting | Pediatric Brain Tumor Consortium | 62 | 2022-04-04 | 2026-07-28 |
| Energy Metabolism in Thyroidectomized Patients Levothyroxine, Liothyronine, Placebo - Thyroid Goiter, Hypothyroidism | Phase 2 | Completed | Virginia Commonwealth University | 13 | 2020-10-28 | 2024-06-14 |
| Treatment of ARDS With Instilled T3 Liothyronine Sodium (T3+0.9% sodium chloride) modified formulation specifically for airway instillation., Non-intervention - ARDS, Human, Lung, Wet | Phase 2 | Completed | University of Minnesota | 19 | 2020-03-30 | 2026-11-03 |
| Developing Oral LT3 Therapy for Heart Failure - HFpEF liothyronine, Placebo - Heart Failure With Preserved Ejection Fraction, Low Triiodothyronine Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-03-08 | 2025-01-08 |
| Developing Oral LT3 Therapy for Heart Failure - HFrEF Liothyronine, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-02-11 | 2024-12-24 |
| Study of Euthyroid Hypothyroxinemia in Metastatic Breast Carcinoma Triiodothyronine (T3) - Metastatic Breast Cancer, Thyroid Dysfunction | Phase 2 | Terminated | Aultman Health Foundation | 7 | 2019-03-01 | 2022-05-13 |
| Identification of Non-responders to Levothyroxine Therapy Levothyroxin, Liothyronine - Hypothyroidism, Biomarkers | Phase 2 | Completed | Oslo University Hospital | 69 | 2018-08-14 | 2021-03-17 |
| Effects of Liothyronine on Energy Expenditure and Cardiovascular Function Liothyronine, Levothyroxine, Placebos - Healthy | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 22 | 2017-10-20 | 2021-03-26 |
| Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients Liothyronine, Levothyroxin, Placebos - Hypothyroidism | Phase 2 / Phase 3 | Completed | Azienda USL Modena | 160 | 2017-03-14 | 2023-04-21 |
| Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations Liothyronine - Insulin Resistance, Diabetes Mellitus | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 7 | 2015-04-17 | 2019-12-05 |
| A Study of T3 Therapy in Patients With Hypothyroidism Liothyronine, Sodium - Hypothyroidism | Phase 2 | Completed | Ipe, LLC | 18 | 2013-03-01 | 2014-07-02 |
| A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin Valproic Acid, Liothyronine Sodium - Thyroid Neoplasm | Phase 2 | Completed | National Cancer Institute (NCI) | 13 | 2010-09-24 | 2018-05-16 |
| Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Oral T3 Low dose, Placebo, Oral T3 high dose - Low T3 Syndrome | Phase 2 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 45 | 2010-04-01 | 2013-03-08 |
| Thyroid and Glucose and Energy Metabolism Liothyronine and Levothyroxine - Thyroid Diseases | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 18 | 2005-03-01 | 2015-02-23 |
Hypothyroidism (5) · Euthyroid Sick Syndromes (4) · Thyroid Diseases (3) · Heart Failure (2) · Medulloblastoma (2) · Thyroid Neoplasms (2) · Breast Neoplasms (1) · Diabetes Mellitus (1) · Endocrine System Diseases (1) · Ependymoma (1) · Goiter (1) · Insulin Resistance (1) · Pneumonia (1) · Pulmonary Edema (1) · Respiratory Distress Syndrome (1)
University of Pennsylvania (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Virginia Commonwealth University (2) · Aultman Health Foundation (1) · Azienda USL Modena (1) · Cantonal Hospital Zenica (1) · Ipe, LLC (1) · National Cancer Institute (NCI) (1) · National Cardiovascular Center Harapan Kita Hospital Indonesia (1) · Oslo University Hospital (1) · Pediatric Brain Tumor Consortium (1) · Sabine Mueller, MD, PhD (1) · University of Minnesota (1)
United States (13) · Bosnia and Herzegovina (1) · Indonesia (1) · Italy (1) · Norway (1)
Anne R Cappola, MD,ScM (2) · Angeliki M Stamatouli, MD (1) · David H Ingbar, MD (1) · Erik Fink Eriksen, Professor (1) · Eva M Marwali, MD (1) · Francesco S Celi, MD, MHSc. (1) · Kong Y Chen, Ph.D. (1) · Matthias Karajannis, MD, MS (1) · Naris Nilubol, M.D. (1) · Rebecca J Brown, M.D. (1) · Ronald A Reikoff, MD (1) · Sabine Mueller (1) · Shruti Trehan, MD (1) · Timothy P Rich, MD (1)
PMID 20447070, PMID 20837917, PMID 21865366, PMID 23585666, PMID 27392538, PMID 31588494, PMID 32191645, PMID 33127750, PMID 34867829, PMID 35273566, PMID 35295986, PMID 35572853, PMID 38061681
R61HL146390 (2), 2017 (1), R01DK137207 (1), R21DK122310 (1), UM1CA081457 (1)