50 completed, 13 recruiting, 13 unknown, 10 terminated. 99 Phase 2, 24 Phase 3, 13 Phase 1.
Follow Tranexamic Acid: new trials by email Literature Review of Tranexamic Acid trials Research Report on Tranexamic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma microneedling, Oral tranexamic acid, Glutathione - Melasma | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 42 | 2026-02-01 | 2026-03-04 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| Effect of TXA on Reducing Bruising After Filler Injection Hyaluronic Acid (HA), Tranexamic Acid (TXA), Saline (placebo) - Facial Filler Injections, Hyaluronic Acid | Phase 2 | Recruiting | University of Wisconsin, Madison | 40 | 2025-12-05 | 2026-07-23 |
| Tranexamic Acid Therapy For The Treatment of Subdural Hematomas Tranexamic Acid 650 MG, Placebo - Chronic Subdural Hematoma | Phase 2 | Not yet recruiting | Baylor College of Medicine | 240 | 2025-10-01 | 2025-05-14 |
| Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia Tranexamic acid, Placebo - Myelodysplastic Syndromes, Acute Myeloid Leukemia | Phase 2 | Recruiting | University of Manitoba | 75 | 2025-09-10 | 2026-04-22 |
| Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA） Low-dose BT-114143, High-dose BT-14143, Tranexamic Acid (IV) - Total Knee Arthroplasty | Phase 2 | Recruiting | ScinnoHub Pharmaceutical Co., Ltd. | 270 | 2025-08-27 | 2025-12-15 |
| Tranexamic Acid : Nebulization vs IV Route for Hemoptysis Tranexamic Acid (TXA) - Hemoptysis, NEBULIZATION | Phase 2 / Phase 3 | Completed | University of Health Sciences Lahore | 172 | 2025-08-01 | 2025-11-28 |
| Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma Melatonin tablet, Tranexamic Acid (TXA) - Melasma (Facial Melasma) | Phase 2 | Enrolling by invitation | Hina Malik | 160 | 2025-06-28 | 2025-09-11 |
| Comparison of Effectiveness of Tranexamic Acid Mesotherapy Versus Glutathione Mesotherapy in Post Burn Facial Hyperpigmentation Tranexamic Acid - Post Burn Facial Hyperpigmentation | Phase 2 | Active not recruiting | King Edward Medical University | 60 | 2025-06-01 | 2025-12-04 |
| The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic Surgery Tranexamic Acid, Normal Saline Solution (NSS), Lidocaine (drug) - Postoperative Blood Loss in Patient Undergoing Orthognathic Surgery | Phase 1 / Phase 2 | Not yet recruiting | Ramathibodi Hospital | 25 | 2025-05-12 | 2025-05-21 |
| Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid Tranexamic Acid - Epistaxis Nosebleed | Phase 1 / Phase 2 | Recruiting | Dr. Anne Conlin | 24 | 2025-05-01 | 2025-05-30 |
| Window of Opportunity Study of Topical Tranexamic Acid for Cutaneous Squamous Cell Carcinoma Tranexamic acid - Cutaneous Squamous Cell Carcinoma | Phase 2 | Withdrawn | University of Florida | 2025-05-01 | 2025-05-02 | |
| Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery Tranexamic acid - Bleeding, Colorectal Disorders | Phase 2 | Recruiting | Kristen Ban | 394 | 2025-02-11 | 2026-05-28 |
| Efficacy of Tranexamic Acid Reducing Blood Loss During Maxillofacial Trauma Surgery Tranexamic Acid (TXA), Normal saline - Hemoglobin Level Measurement, Blood Loss During Surgery | Phase 2 | Completed | Nishtar Medical University | 60 | 2025-01-01 | 2026-02-06 |
| Effects of Oral Tranexamic Acid Following Total Knee Arthroplasty Tranexamic acid - Postoperative Pain | Phase 2 | Completed | Matthew Grosso, MD | 86 | 2024-06-10 | 2026-10-29 |
| Evaluating the Effect of Tranexamic Acid on the Clinical Outcomes in Patients With Traumatic Brain Injury Tranexamic Acid (TXA), Normal saline - Traumatic Brain Injury | Phase 1 / Phase 2 | Unknown | Mansoura University | 90 | 2024-03-25 | 2024-05-10 |
| Tranexamic Acid in Nasal Mohs Reconstruction Treatment (tranexamic acid and 1% lidocaine with 1:100,000 epinephrine), Control (1% lidocaine with 1:100,000 epinephrine) - Postoperative Bleeding, Skin Cancer Face | Phase 2 | Recruiting | Vanderbilt University Medical Center | 100 | 2024-03-19 | 2026-09-09 |
| A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty Placebo, Group 1: perfusion of 300 mg Exacyl, Group 2: perfusion of 500 mg Exacyl - Arthropathy of Hip | Phase 2 | Completed | Centre Hospitalier Universitaire de Saint Etienne | 170 | 2023-12-07 | 2025-11-26 |
| Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients Tranexamic Acid, stroke-physiological saline solution (SPSS) - Metastasis Spinal Tumor | Phase 1 / Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 150 | 2023-12-01 | 2025-02-10 |
| Tranexamic Acid for The Management of Bleeding Gastrointestinal Angioectasias Tranexamic Acid (TXA) treatment, Placebo - Anemia, Small Bowel Bleeding | Phase 2 / Phase 3 | Completed | Louisiana State University Health Sciences Center in New Orleans | 40 | 2023-08-01 | 2025-08-15 |
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Hemorrhage (27) · Postpartum Hemorrhage (8) · Blood Loss, Surgical (6) · Postoperative Hemorrhage (6) · Cerebral Hemorrhage (5) · Hematoma, Subdural, Chronic (5) · Melanosis (4) · Osteoarthritis (4) · COVID-19 (3) · Osteoarthritis, Knee (3) · Shock (3) · Stroke (3) · Thrombocytopenia (3) · Wounds and Injuries (3) · Brain Diseases (2)
Assiut University (5) · Ain Shams University (3) · St. Olavs Hospital (3) · Centre Hospitalier Universitaire de Saint Etienne (2) · Henry Ford Health System (2) · Leading BioSciences, Inc (2) · Mansoura University (2) · Neuroscience Trials Australia (2) · Northwestern University (2) · University of Alabama at Birmingham (2) · Washington University School of Medicine (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ahmed Alanwar (1) · Alex Ekwueme Federal University Teaching Hospital (1) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1)
United States (37) · Canada (11) · Egypt (8) · Pakistan (7) · China (3) · France (3) · Mexico (3) · Norway (3) · Australia (2) · Finland (2) · Nepal (2) · Switzerland (2) · Thailand (2) · Belgium (1) · Colombia (1)
Birger Henning Endreseth, MD PhD (2) · Timothy J Ness, MD PhD (2) · Ali Abdalvand, MD (1) · Amal Ramadan, MBBCh (1) · Angela Jerath (1) · Anne Conlin, Assistant Professor, University of Ottawa, HBA&Sc, MD, FRCSC (1) · Atte Meretoja, MD (1) · Bently Doonan, MD, MS (1) · Bikal Ghimire, MS (1) · Brandon Yuan, MD (1) · Brent Senior, MD (1) · Carlos Acosta-Olivo, PhD (1) · Catherine Olinger, M.D. (1) · Chandrashekhar Gendle, MD PhD (1)
PMID 37870112, PMID 10400410, PMID 11413430, PMID 15273542, PMID 1598671, PMID 16531440, PMID 16810012, PMID 17005947, PMID 17538089, PMID 17943760, PMID 19011538, PMID 19638912, PMID 19770617, PMID 20554319, PMID 21364458, PMID 21600028, PMID 22012809, PMID 23371895, PMID 23680226, PMID 23955184, PMID 23981692, PMID 24418941, PMID 25184917, PMID 27150916, PMID 27455842, PMID 27599329, PMID 27699724, PMID 28244907, PMID 28726212, PMID 28939033, PMID 28968480, PMID 28976426, PMID 29107495, PMID 29524595, PMID 29716640, PMID 29723672, PMID 30354984, PMID 30376893, PMID 31022078, PMID 31136475, PMID 31271691, PMID 31299040, PMID 31491796, PMID 32070395, PMID 32152813, PMID 32278572, PMID 32897344, PMID 33013880, PMID 33128912, PMID 33248975
2018 (2), 2015 (1), 2016 (1), 2017 (1), K23HL141640 (1), KL2TR001877 (1), R01HD110109 (1), U01HL077863 (1), UL1TR001876 (1)