8 completed, 1 enrolling by invitation, 1 recruiting, 1 suspended. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 8, Enrolling by invitation 1, Recruiting 1, Suspended 1, Unknown 1 |
Follow trandolapril: new trials by email Literature Review of trandolapril trials Research Report on trandolapril
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients RAS-antagonist and beta-blocker up-to maximal dosages, RAS-antagonist and beta-blocker none or at stable dose - Heart Diseases, Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | Martin Huelsmann | 2400 | 2016-02-01 | 2023-03-14 |
| Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery ACEI continuation, ACEI omission - Hypotension on Induction | Phase 4 | Completed | University of Nebraska | 291 | 2015-06-01 | 2023-09-25 |
| Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study) Hydrochlorothiazide, Trandolapril - Hypertension | Phase 4 | Completed | University of Florida | 24 | 2007-05-01 | 2014-06-17 |
| Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Captopril, Enalapril, Lisinopril - Heart Failure, Ventricular Dysfunction, Left | Phase 4 | Completed | AstraZeneca | 252 | 2006-10-01 | 2012-06-25 |
| Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis Captopril and Trandolapril, Captopril Test Dose and Trandolapril - Aortic Stenosis | Phase 4 | Unknown | Copenhagen University Hospital, Rigshospitalet | 64 | 2005-11-01 | 2008-09-03 |
| Russian Study of the Efficacy and Safety of Tarka in Patients With Hypertension trandolapril/verapamil - Hypertension | Phase 4 | Completed | Abbott | 120 | 2004-06-01 | 2008-07-10 |
| Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) trandolapril/verapamil, (Hyzaar) losartan/hydrochlorothiazide - Hypertension, Metabolic Syndrome | Phase 4 | Completed | Abbott | 280 | 2004-03-01 | 2008-07-15 |
| Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients (TRAIL) Trandolapril - Hypertension | Phase 4 | Completed | Abbott | 2000 | 2004-03-01 | 2008-07-22 |
| Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) trandolapril/verapamil, Lotrel (amlodipine/benazepril) - Hypertension, Diabetes | Phase 4 | Completed | Abbott | 357 | 2004-01-01 | 2008-07-15 |
| A Study for Prevention of Kidney Disease in Diabetic Patients (BENEDICT) trandolapril, trandolapril/verapamil, placebo - Hypertension, Diabetes | Phase 4 | Completed | Abbott | 1204 | 1997-03-01 | 2008-07-15 |
Hypertension (7) · Albuminuria (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Metabolic Syndrome (2) · Aortic Valve Stenosis (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Coronavirus Infections (1) · Glucose Intolerance (1) · Heart Diseases (1) · Heart Failure (1) · Hyperkalemia (1) · Obesity, Abdominal (1) · Proteinuria (1)
Abbott (5) · AstraZeneca (1) · Baylor Research Institute (1) · Copenhagen University Hospital, Rigshospitalet (1) · Martin Huelsmann (1) · National University of Ireland, Galway, Ireland (1) · University of Florida (1) · University of Nebraska (1)
United States (4) · Austria (1) · Denmark (1) · Ireland (1) · Netherlands (1) · New Zealand (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Bjorn Eriksson, MD (1) · Christian Hassager, MD, Phd (1) · Hans Persson, MD, PhD (1) · Jason F Shiffermiller, MD, MPH (1) · John William McEvoy, MBBCh MHS (1) · Martin Huelsmann, Doz.Dr. (1) · Morten Dalsgaard, MD (1) · Peer Grande, MD, Phd (1) · Peter Clemmensen, MD, Phd (1) · Rhonda M. Cooper-DeHoff, Pharm D, MS (1) · Victor Gorin, MD (1)
PMID 17130190, PMID 18443191, PMID 20139439, PMID 21243736, PMID 22773704, PMID 23733198, PMID 30261084
K23HL086558 (1)