15 completed, 2 recruiting, 1 enrolling by invitation, 1 suspended. 12 Phase 4, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 8, Enrolling by invitation 1, Recruiting 1, Suspended 1, Unknown 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 2, Recruiting 1 |
Follow trandolapril: new trials by email Literature Review of trandolapril trials Research Report on trandolapril
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) Finerenone, Semaglutide, Lotensin - Chronic Kidney Disease, Type 2 Diabetes | Phase 4 | Enrolling by invitation | Baylor Research Institute | 64 | 2026-04-08 | 2026-10-13 |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam - Community-acquired Pneumonia, Influenza, COVID-19 | Phase 3 | Recruiting | UMC Utrecht | 20000 | 2016-04-11 | 2024-07-12 |
| NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients RAS-antagonist and beta-blocker up-to maximal dosages, RAS-antagonist and beta-blocker none or at stable dose - Heart Diseases, Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | Martin Huelsmann | 2400 | 2016-02-01 | 2023-03-14 |
| Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery ACEI continuation, ACEI omission - Hypotension on Induction | Phase 4 | Completed | University of Nebraska | 291 | 2015-06-01 | 2023-09-25 |
| Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients? - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril. - Heart Failure | Phase 3 | Completed | University Hospital, Clermont-Ferrand | 35 | 2011-08-01 | 2014-10-01 |
| Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study) Hydrochlorothiazide, Trandolapril - Hypertension | Phase 4 | Completed | University of Florida | 24 | 2007-05-01 | 2014-06-17 |
| Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Captopril, Enalapril, Lisinopril - Heart Failure, Ventricular Dysfunction, Left | Phase 4 | Completed | AstraZeneca | 252 | 2006-10-01 | 2012-06-25 |
| Bioequivalence Study of Trandolapril 4 mg Tablets of Dr. Reddy's Under Fed Conditions Trandolapril, Mavik - Healthy | Phase 1 | Completed | Dr. Reddy's Laboratories Limited | 52 | 2006-03-01 | 2010-07-19 |
| Bioequivalence Study of Trandolapril 4 mg Tablets of Dr. Reddy's Under Fasting Conditions Trandolapril, Mavik - Healthy | Phase 1 | Completed | Dr. Reddy's Laboratories Limited | 52 | 2006-03-01 | 2010-07-19 |
| Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis Captopril and Trandolapril, Captopril Test Dose and Trandolapril - Aortic Stenosis | Phase 4 | Unknown | Copenhagen University Hospital, Rigshospitalet | 64 | 2005-11-01 | 2008-09-03 |
| Trandolapril 4 mg Tablet Under Non-Fasting Conditions Trandolapril 4 mg Tablets, Mavik® 4 mg Tablets - Healthy | Phase 1 | Completed | Teva Pharmaceuticals USA | 50 | 2004-10-01 | 2024-08-20 |
| Trandolapril 4 mg Tablet Under Fasting Conditions Trandolapril 4 mg Tablets, Mavik® 4 mg Tablets - Healthy | Phase 1 | Completed | Teva Pharmaceuticals USA | 40 | 2004-10-01 | 2024-08-20 |
| Russian Study of the Efficacy and Safety of Tarka in Patients With Hypertension trandolapril/verapamil - Hypertension | Phase 4 | Completed | Abbott | 120 | 2004-06-01 | 2008-07-10 |
| Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) trandolapril/verapamil, (Hyzaar) losartan/hydrochlorothiazide - Hypertension, Metabolic Syndrome | Phase 4 | Completed | Abbott | 280 | 2004-03-01 | 2008-07-15 |
| Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients (TRAIL) Trandolapril - Hypertension | Phase 4 | Completed | Abbott | 2000 | 2004-03-01 | 2008-07-22 |
| Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) trandolapril/verapamil, Lotrel (amlodipine/benazepril) - Hypertension, Diabetes | Phase 4 | Completed | Abbott | 357 | 2004-01-01 | 2008-07-15 |
| Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives sibutramine, verapamil/trandolapril, metoprolol/HCT - Obesity, Hypertension | Phase 3 | Completed | Abbott | 171 | 2002-02-01 | 2008-05-19 |
| A Study for Prevention of Kidney Disease in Diabetic Patients (BENEDICT) trandolapril, trandolapril/verapamil, placebo - Hypertension, Diabetes | Phase 4 | Completed | Abbott | 1204 | 1997-03-01 | 2008-07-15 |
Hypertension (9) · Albuminuria (2) · COVID-19 (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Heart Failure (2) · Metabolic Syndrome (2) · Aortic Valve Stenosis (1) · Cardiovascular Diseases (1) · Community-Acquired Pneumonia (1) · Coronavirus Infections (1) · Glucose Intolerance (1) · Heart Diseases (1) · Hyperkalemia (1) · Influenza, Human (1)
Abbott (6) · Dr. Reddy's Laboratories Limited (2) · Teva Pharmaceuticals USA (2) · AstraZeneca (1) · Baylor Research Institute (1) · Copenhagen University Hospital, Rigshospitalet (1) · Martin Huelsmann (1) · National University of Ireland, Galway, Ireland (1) · UMC Utrecht (1) · University Hospital, Clermont-Ferrand (1) · University of Florida (1) · University of Nebraska (1) · University of Utah (1)
United States (6) · Canada (3) · India (3) · France (2) · Ireland (2) · Netherlands (2) · New Zealand (2) · Spain (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Colombia (1) · Croatia (1) · Czechia (1)
Dr. Umesh Dhakate, M.B.B.S (2) · Adam P Bress, PharmD, MS (1) · Bjorn Eriksson, MD (1) · Christian Hassager, MD, Phd (1) · Colin McArthur, Dr (1) · Derek Angus, Prof (1) · Hans Persson, MD, PhD (1) · Jason F Shiffermiller, MD, MPH (1) · John Marshall, Prof (1) · John William McEvoy, MBBCh MHS (1) · Lennie Derde, MD (1) · Marc Bonten, Prof (1)
PMID 17130190, PMID 18443191, PMID 20139439, PMID 21243736, PMID 22394464, PMID 22773704, PMID 23733198, PMID 30261084, PMID 32267771, PMID 32876697, PMID 33394942, PMID 33509275, PMID 33631065, PMID 33891615, PMID 34251506, PMID 34351721, PMID 34351722, PMID 34473343, PMID 34606578, PMID 35315874, PMID 36942550, PMID 36967714, PMID 37039790, PMID 37489818, PMID 37877585, PMID 37888913, PMID 40261382, PMID 40360262, PMID 42823695
2015 (1), 2023 (1), K23HL086558 (1)