14 completed, 4 recruiting, 3 terminated, 2 unknown. 25 Phase 2, 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 25 | Completed 14, Recruiting 4, Terminated 3, Unknown 2, Withdrawn 2 |
| Phase 3 | 8 | Completed 4, Recruiting 2, Terminated 1, Withdrawn 1 |
Follow Tenecteplase: new trials by email Literature Review of Tenecteplase trials Research Report on Tenecteplase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repeated Intravenous Thrombolysis for Ischemic Stroke Within 3.0 Hours of Onset With Tenecteplase (RITIS-TNK) Tenecteplase - Ischemic Stroke | Phase 2 | Recruiting | General Hospital of Shenyang Military Region | 120 | 2026-03-25 | 2026-04-01 |
| Repeated Intravenous Thrombolysis for Ischemic Stroke With Medium to Large Vessel Occlusion Presenting Within 4.5 Hours of Onset With Tenecteplase (RITIS-TNK2) Tenecteplase - Ischemic Stroke | Phase 2 | Recruiting | General Hospital of Shenyang Military Region | 198 | 2026-03-25 | 2026-04-01 |
| Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial tenecteplase - Ischemic Stroke, Acute Disease | Phase 2 / Phase 3 | Recruiting | ProMedica Health System | 132 | 2025-07-30 | 2026-01-21 |
| Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK) Tenecteplase - Stroke, Ischemic | Phase 2 / Phase 3 | Completed | General Hospital of Shenyang Military Region | 80 | 2023-03-21 | 2025-06-17 |
| Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation Tenecteplase, endovascular thrombectomy alone - Acute Ischemic Stroke, Intracranial Artery Occlusion | Phase 2 / Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 208 | 2023-01-24 | 2024-04-11 |
| Additive Effects of Intra-arterial Tenecteplase for Successful Thrombectomy Due to Acute Basilar Artery Occlusion Tenecteplase for Injection, Saline - Basilar Artery Occlusion, Thrombectomy | Phase 2 | Unknown | First Hospital of China Medical University | 520 | 2023-01-01 | 2022-10-14 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| Extending the Time Window for Tenecteplase by Recanalization of Basilar Artery Occlusion in Posterior Circulation Stroke Tenecteplase, Standard Care (which may include intravenous Alteplase) - Basilar Artery Occlusion | Phase 2 / Phase 3 | Recruiting | University of Melbourne | 688 | 2021-11-29 | 2026-05-06 |
| CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase II Tenecteplase, The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy) - Stroke | Phase 2 | Completed | Huashan Hospital | 224 | 2021-09-28 | 2023-11-29 |
| Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II） Alteplase, Tenecteplase - Acute Ischemic Stroke | Phase 2 | Unknown | Beijing Tiantan Hospital | 225 | 2021-05-02 | 2022-03-31 |
| Tenecteplase in Patients With COVID-19 Tenecteplase, Placebo - COVID-19, Respiratory Failure | Phase 2 | Completed | Hooman Poor | 13 | 2020-09-25 | 2023-04-06 |
| CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase Low dose tenecteplase, High dose tenecteplase - Stroke | Phase 2 | Completed | Huashan Hospital | 86 | 2019-12-09 | 2022-03-31 |
| Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance Tenecteplase, Intravenous tissue plasminogen activator (tPA) - Stroke, Acute, Stroke Ischemic | Phase 2 | Completed | Melbourne Health | 104 | 2019-06-20 | 2021-12-08 |
| Determining the Optimal Dose of Tenecteplase Before Endovascular Therapy for Ischaemic Stroke (EXTEND-IA TNK Part 2) Tenecteplase - Ischemic Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 300 | 2017-12-06 | 2020-03-04 |
| Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion rt-PA, tenecteplase - Nervous System Disorders, Cerebral Artery | Phase 2 | Withdrawn | University Hospital Center of Martinique | 2016-07-01 | 2018-06-21 | |
| Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke Tenecteplase, Tissue Plasminogen Activator - Ischemic Stroke | Phase 2 | Completed | Neuroscience Trials Australia | 202 | 2015-03-23 | 2018-03-30 |
| Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN) Tenecteplase, Alteplase - Ischemic Stroke | Phase 2 / Phase 3 | Withdrawn | Reza Behrouz, DO | 2015-01-01 | 2015-09-23 | |
| TNK-tPA Evaluation for Minor Ischemic Stroke With Proven Occlusion Tenecteplase - Ischemic Stroke | Phase 2 | Completed | University of Calgary | 50 | 2012-07-01 | 2020-11-25 |
| Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST) Tenecteplase, alteplase - Stroke | Phase 2 | Completed | NHS Greater Glasgow and Clyde | 104 | 2011-12-01 | 2018-08-03 |
| Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) - Cerebral Infarction, Brain Ischemia | Phase 2 | Completed | University of Alberta | 20 | 2009-10-01 | 2018-04-06 |
Showing 20 of 25. Sign in to see all of them.
Ischemic Stroke (15) · Stroke (10) · Cerebral Infarction (3) · Nervous System Diseases (3) · Brain Diseases (2) · Brain Ischemia (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Cerebrovascular Disorders (2) · Ischemia (2) · ST Elevation Myocardial Infarction (2) · Vascular Diseases (2) · Acute Disease (1) · Brain Infarction (1) · COVID-19 (1)
General Hospital of Shenyang Military Region (3) · Huashan Hospital (2) · Neuroscience Trials Australia (2) · University of Alberta (2) · Beijing Tiantan Hospital (1) · C. Michael Gibson, MS, MD (1) · First Hospital of China Medical University (1) · Hooman Poor (1) · Kaiser Permanente (1) · Melbourne Health (1) · NHS Greater Glasgow and Clyde (1) · ProMedica Health System (1) · Reza Behrouz, DO (1) · The First Affiliated Hospital of University of Science and Technology of China (1) · University Hospital Center of Martinique (1)
China (8) · United States (6) · Australia (4) · Canada (3) · New Zealand (2) · Brazil (1) · France (1) · Italy (1) · United Kingdom (1)
Bruce Campbell (1) · C. Michael Gibson, MS, MD (1) · Cecilia Becattini, MD (1) · E. Clarke Haley, Jr., M.D. (1) · Fana Alemseged (1) · Giancarlo Agnelli, MD (1) · Hooman Poor, MD (1) · Hyo-Chun Yoon, MD (1) · J Mocco, MD (1) · Jeffrey L Saver, MD (1) · John L. P. Thompson, Ph.D. (1) · Keith Muir (1) · Kenneth Butcher, MD, PhD (1) · Michael D Hill, MD,MSc FRCPC (1)
PMID 20185783, PMID 25726502, PMID 29694815, PMID 33408145, PMID 34906976, PMID 35017305, PMID 36289001, PMID 36878701, PMID 38502892, PMID 40497495, PMID 41446320, PMID 16574919, PMID 19233036, PMID 19833379, PMID 20651267, PMID 21315210, PMID 22435369, PMID 23418571, PMID 25677596, PMID 26387127, PMID 26514192, PMID 27965285, PMID 28780236, PMID 28952914, PMID 31564231, PMID 31870492, PMID 32078683, PMID 33023423, PMID 33464335, PMID 35487712, PMID 35525251, PMID 38124230, PMID 38286484, PMID 39435713, PMID 39744861, PMID 39772606, PMID 39809509, PMID 40396577, PMID 40674670, PMID 42623571, PMID 42629154, PMID 9186381
R01NS037666 (1), R01NS045170 (1)