29 completed, 4 withdrawn, 3 unknown, 2 terminated. 39 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 39 | Completed 29, Withdrawn 4, Unknown 3, Terminated 2, Recruiting 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
Follow Syntocinon: new trials by email Literature Review of Syntocinon trials Research Report on Syntocinon
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls Oxytocin nasal spray, Placebo - Arginine Vasopressin Deficiency, Central Diabetes Insipidus | Phase 2 | Recruiting | University Hospital, Basel, Switzerland | 42 | 2025-07-01 | 2025-10-03 |
| Oxytocin on Approach Bias and Craving Oxytocin, Placebo - Alcohol Use Disorder | Phase 2 | Withdrawn | Jennifer Mitchell | 2023-11-01 | 2022-06-06 | |
| Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT Oxytocin nasal spray, Saline (NaCl 0,9 %) (placebo) - Benzodiazepine Dependence | Phase 2 | Completed | St. Olavs Hospital | 66 | 2022-03-01 | 2026-09-28 |
| Prevention of Primary Postpartum Haemorrhage Misoprostol, Oxytocin - Primary, Post Partum Hemorrhage | Phase 2 | Unknown | Islamabad Medical and Dental College | 180 | 2021-02-03 | 2021-02-25 |
| A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia Oxytocin, Placebo - Schizophrenia | Phase 2 | Terminated | VA Office of Research and Development | 26 | 2020-01-13 | 2026-01-20 |
| Oxytocin Treatment for Alcohol Use Disorders Oxytocin, Placebo - Alcohol Use Disorder | Phase 2 | Withdrawn | University of North Carolina, Chapel Hill | 2019-10-01 | 2019-11-13 | |
| Inhaled Oxytocin and HPA Axis Reactivity Intranasal Oxytocin, Placebo - Depression, Postpartum, Anxiety Disorders | Phase 2 | Completed | University of North Carolina, Chapel Hill | 109 | 2019-02-07 | 2025-08-08 |
| Intranasal Oxytocin and Food Intake in Obese Adolescents Syntocinon, Placebo - Obesity | Phase 2 | Withdrawn | Shana McCormack, MD | 2018-09-01 | 2018-12-26 | |
| Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome Intranasal Oxytocin (IN-OXT), Matched Placebo - Prader-Willi Syndrome, Hyperphagia | Phase 2 | Completed | Eric Hollander | 32 | 2018-04-11 | 2025-02-07 |
| Intranasal Oxytocin for Frontotemporal Dementia Syntocinon - Frontotemporal Dementia | Phase 2 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 112 | 2018-01-31 | 2023-12-15 |
| Stimulant Oxytocin Study Intranasal oxytocin, Intranasal placebo - Stimulant Use & Co-occuring Opioid Use Disorders | Phase 2 | Completed | VA Office of Research and Development | 42 | 2018-01-26 | 2021-06-10 |
| Oxytocin and Eating Syntocinon, Placebos - Weight Gain | Phase 2 | Unknown | Yale-NUS College | 60 | 2017-09-01 | 2017-07-21 |
| Intranasal Oxytocin for Infants With Prader-Willi Syndrome Oxytocin, Placebo - Prader-Willi Syndrome | Phase 1 / Phase 2 | Completed | University of Florida | 15 | 2017-08-01 | 2020-03-26 |
| Influence of Oxytocin on Neurophysiological Responses to Live Faces Oxytocin, Placebo - Oxytocin | Phase 1 / Phase 2 | Completed | KU Leuven | 56 | 2017-07-24 | 2019-08-01 |
| The Effects of Oxytocin in Obese Adults oxytocin nasal spray, Placebo - Obesity | Phase 2 | Completed | Massachusetts General Hospital | 61 | 2017-07-01 | 2024-02-07 |
| Autism Oxytocin Brain Project 8 International Units (IU) of Oxytocin, 24IU of Oxytocin, 48IU of Oxytocin - Autism, Autism Spectrum Disorder | Phase 2 | Completed | Emory University | 51 | 2017-05-10 | 2021-01-12 |
| Oxytocin and Brain Responses in Maternal Addiction Oxytocin, Placebos, Functional MRI scanning - Maternal Behavior, Maternal Addiction | Phase 2 | Terminated | Lane Strathearn, MBBS PhD | 59 | 2017-05-05 | 2025-03-26 |
| Evaluating the Efficacy of Intranasal Oxytocin Among Individuals With Persistent Pain Intranasal Oxytocin, Placebo - Chronic Pain, Pelvic Pain | Phase 2 / Phase 3 | Completed | University of Calgary | 24 | 2016-11-01 | 2022-05-18 |
| Intranasal Oxytocin in Hypothalamic Obesity Syntocinon, Placebo (for Syntocinon) - Craniopharyngioma, Hypothalamic Obesity | Phase 2 | Completed | Shana McCormack, MD | 18 | 2016-10-01 | 2022-10-05 |
| Oxytocin and Social Cognitive Skills Groups Oxytocin, Social Cognitive Skills Training, Facilitated Play Therapy - Autism Spectrum Disorder | Phase 2 | Completed | Rush University Medical Center | 40 | 2016-06-15 | 2024-04-05 |
Showing 20 of 39. Sign in to see all of them.
Autism Spectrum Disorder (8) · Autistic Disorder (5) · Prader-Willi Syndrome (4) · Anxiety Disorders (3) · Obesity (3) · Schizophrenia (3) · Alcoholism (2) · Depression, Postpartum (2) · Frontotemporal Dementia (2) · Hyperphagia (2) · Postpartum Hemorrhage (2) · Chronic Pain (1) · Cocaine-Related Disorders (1) · Craniopharyngioma (1) · Depressive Disorder (1)
Alexander Kolevzon (2) · Emory University (2) · Evdokia Anagnostou (2) · Holland Bloorview Kids Rehabilitation Hospital (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Massachusetts General Hospital (2) · Shana McCormack, MD (2) · University of North Carolina, Chapel Hill (2) · VA Office of Research and Development (2) · Yale-NUS College (2) · Ain Shams University (1) · Concordia University, Montreal (1) · Eric Hollander (1) · Islamabad Medical and Dental College (1) · Jennifer Mitchell (1)
United States (25) · Canada (7) · Australia (1) · Belgium (1) · Egypt (1) · France (1) · Norway (1) · Pakistan (1) · Singapore (1) · Switzerland (1)
Evdokia Anagnostou, M.D. (3) · Eric Hollander, MD (2) · Suma Jacob, M.D., Ph.D. (2) · Alexander Kolevzon, MD (1) · Alison M Stuebe, MD, MSc (1) · Allan L Reiss (1) · Annie Dupuis, Ph.D. (1) · Christopher Stauffer, MD (1) · Cort Pedersen, MD (1) · Derek Mitchell, PhD (1) · Edwin Cook, M.D. (1) · Elissar Andari, PhD (1) · Elizabeth A Lawson, MD (1) · Elizabeth C Finger, M.D. (1) · Erica J Duncan, MD (1)
PMID 37811711, PMID 21862226, PMID 23216716, PMID 26994593, PMID 28416501, PMID 30261917, PMID 32963103, PMID 33112417, PMID 33587397, PMID 34593045, PMID 35141873, PMID 37883133, PMID 38445382, PMID 38767196, PMID 38815173, PMID 39862881, PMID 42714565
1IK2CX001495-01 (1), 2019 (1), I01CX001761 (1), P50MH082999 (1), P50MH100023 (1), R01AA025942 (1), R01HD093901 (1), R21HD090396 (1)