10 completed, 2 terminated, 2 withdrawn, 1 recruiting. 7 Not applicable, 4 Phase 2, 2 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 5, Terminated 1, Unknown 1 |
| Phase 2 | 4 | Completed 2, Recruiting 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Synthroid: new trials by email Literature Review of Synthroid trials Research Report on Synthroid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) Levothyroxine, Enlicitide Decanoate - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2024-07-08 | 2024-10-03 |
| Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans Synthroid, Placebo - Nonalcoholic Steatohepatitis, Liver Fibrosis | Phase 2 | Recruiting | VA Office of Research and Development | 128 | 2023-04-01 | 2026-02-19 |
| Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism Levothyroxine, Placebo - Subclinical Hypothyroidism | Phase 4 | Completed | VA Office of Research and Development | 52 | 2021-03-24 | 2023-11-18 |
| Wound Complications in Head and Neck Surgery Levothyroxine - Hypothyroidism; Surgery, Head and Neck Cancer | Completed | University of Michigan | 51 | 2017-05-01 | 2020-06-01 | |
| The Effects of T4 Versus T4/T3 on Psychological Distress After Total Thyroidectomy in Thyroid Cancer Patients Comthyroid, Synthroid - Thyroid Cancer, Distress | Not applicable | Completed | Inje University | 150 | 2016-12-01 | 2019-02-22 |
| Is Levothyroxine Alone Adequate Thyroid Hormone Replacement? thyroidectomy, levothyroxine in thyroidectomy patients - Postsurgical Hypothyroidism, Hypothyroidism | Terminated | University of Colorado, Denver | 12 | 2016-11-01 | 2023-06-08 | |
| Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding Levothyroxine - Hypothyroidism | Phase 4 | Withdrawn | Jocelyne Karam | 2015-10-01 | 2021-09-22 | |
| Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Levothyroxine, Placebo - Hypothyroidism, Neoplasms | Phase 2 / Phase 3 | Withdrawn | University of Alberta | 2015-07-01 | 2022-07-13 | |
| Mechanistic Study of Subclinical Hypothyroidism In the Elderly Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone - Subclinical Hypothyroidism | Not applicable | Completed | University of Pennsylvania | 14 | 2015-01-01 | 2021-03-09 |
| Treatment Trial of Subclinical Hypothyroidism in Down Syndrome Levothyroxine - Down Syndrome, Subclinical Hypothyroidism | Not applicable | Completed | Children's Hospital of Philadelphia | 12 | 2013-01-01 | 2019-09-06 |
| Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment Levothyroxine, Desiccated thyroid extract - Primary Hypothyroidism. | Not applicable | Unknown | Walter Reed National Military Medical Center | 180 | 2012-05-01 | 2012-12-04 |
| Safety and Efficacy of Empiric Levothyroxine (LT4) Dose Increase Versus Individualized LT4 Dose Increase in Hypothyroid Women During Pregnancy levothyroxine - Pregnancy Related, Thyroid | Not applicable | Completed | Medstar Health Research Institute | 60 | 2011-08-01 | 2018-03-29 |
| Sunitinib or Cediranib for Alveolar Soft Part Sarcoma Cediranib, Sunitinib, Prochlorperazine - Sarcoma, Alveolar Soft Part | Phase 2 | Completed | National Cancer Institute (NCI) | 34 | 2011-07-18 | 2026-02-02 |
| Subclinical Hypothyroidism and Mind in the Elderly levothyroxine sodium, excipient without levothyroxine (placebo) - Subclinical Hypothyroidism | Phase 2 / Phase 3 | Completed | Universidad Autonoma de Nuevo Leon | 70 | 2009-06-01 | 2012-06-28 |
| Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors Levothyroxine, Liothyronine - Hypothyroidism, Brain Tumor | Not applicable | Terminated | M.D. Anderson Cancer Center | 12 | 2006-02-01 | 2013-06-24 |
| Thyroid Hormone Dose Adjustment in Pregnancy Anticipatory dose increase of levothyroxine, levothyroxine - Pregnancy, Hypothyroidism | Not applicable | Completed | Brigham and Women's Hospital | 48 | 2005-07-01 | 2016-12-23 |
Hypothyroidism (8) · Thyroid Diseases (4) · Anxiety Disorders (1) · Brain Neoplasms (1) · Cognitive Dysfunction (1) · Depression (1) · Down Syndrome (1) · Fatigue (1) · Head and Neck Neoplasms (1) · Laryngeal Neoplasms (1) · Liver Cirrhosis (1) · Neoplasms (1) · Non-alcoholic Fatty Liver Disease (1) · Postoperative Complications (1) · Sarcoma, Alveolar Soft Part (1)
VA Office of Research and Development (2) · Brigham and Women's Hospital (1) · Children's Hospital of Philadelphia (1) · Inje University (1) · Jocelyne Karam (1) · M.D. Anderson Cancer Center (1) · Medstar Health Research Institute (1) · Merck Sharp & Dohme LLC (1) · National Cancer Institute (NCI) (1) · Universidad Autonoma de Nuevo Leon (1) · University of Alberta (1) · University of Colorado, Denver (1) · University of Michigan (1) · University of Pennsylvania (1) · Walter Reed National Military Medical Center (1)
United States (13) · Mexico (1) · South Korea (1)
Alice P Chen, M.D. (1) · Andrea Kelly, MD, MSCE (1) · Anne R Cappola, MD, ScM (1) · Bryan R Haugen, M.D. (1) · Erik Alexander, MD (1) · Jamal A Ibdah, MD PhD (1) · Jesus Z Villarreal-Perez, M.D. (1) · Jocelyne Karam, MD (1) · Lilia Cardenas-Ibarra, M.D. (1) · Spyridoula Maraka, MD MS (1) · Victor Levin, MD (1)
PMID 20463094, PMID 28911144, PMID 36302173, PMID 40736623
I01CX002436 (1), K24AG042765 (1), R01HD071981 (1), UL1TR001082 (1)