26 completed, 4 unknown, 2 recruiting, 2 withdrawn. 10 Phase 4, 7 Not applicable, 7 Phase 3, 4 Phase 1, 3 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MAGNESIUM & SSRI VS SSRI ALONE AMONG PATIENTS OF MAJOR DEPRESSIVE DISORDER Use of magnesium with SSRI, SSRI - Major Depressive Diorder | Phase 2 | Active not recruiting | University of Child Health Sciences and Children's Hospital, Lahore | 50 | 2025-12-01 | 2026-03-09 |
| Comparison of the Effectiveness Level of Virtual Reality Exposure Therapy With Sertraline Treatment in Social Anxiety Disorder Virtual Reality Exposure Therapy, Sertraline (Oral Antidepressant) - Social Anxiety Disorder | Phase 4 | Recruiting | Emine Kanmaz | 56 | 2024-11-15 | 2025-09-25 |
| A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression Vortioxetine Tablet, SSRI - Major Depressive Disorder | Completed | Takeda | 147777 | 2024-06-01 | 2025-03-03 | |
| Precision Psychiatry for Depression: Immune Response and Affective Symptoms as Predictors of Response to Antidepressants SSRI - Depression, Inflammation | Completed | Germans Trias i Pujol Hospital | 50 | 2024-04-01 | 2026-09-14 | |
| Detoxification From the Lipid Tract electroencephalogram biofeedback, electrical brain stimulation, ultra-low frequency transcranial magnetic stimulation - COVID-19 Vaccine Adverse Reaction | Phase 4 | Completed | Pachankis, Yang I., M.D. | 1 | 2024-02-26 | 2024-04-10 |
| Non-invasive BCI and Application Verification for Depressed People SSRI, rTMS, Neuro-Feedback - Depression, Major Depressive Disorder | Phase 4 | Recruiting | Shanghai Mental Health Center | 400 | 2023-07-01 | 2024-05-16 |
| Psychiatric Orders in Psychoanalytic Treatment of ASD Psychoanalysis, sertraline 50mg, Duloxetine 20 MG - PTSD, Autism Spectrum Disorder High-Functioning | Unknown | Yang I. Pachankis, PhD | 1 | 2023-06-01 | 2023-07-05 | |
| Intradermal Acupuncture Versus Sham Acupuncture and SSRI for Treating Adolescents With Major Depressive Disorder SSRI, SIA, AIA - Major Depressive Disorder | Not applicable | Unknown | Xiaomei Shao | 120 | 2022-11-01 | 2023-04-27 |
| The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder SSRI, SIA, AIA - Major Depressive Disorder | Not applicable | Completed | Xiaomei Shao | 120 | 2022-11-01 | 2024-02-20 |
| SSRI's and the Rate of Progression From MCI to Dementia SSRI - Mild Cognitive Impairment, Dementia | Withdrawn | Ohio State University | 2021-09-01 | 2023-10-11 | ||
| A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women Sertraline, Interpersonal therapy - Perinatal Depression, HIV-1-infection | Phase 4 | Completed | University of North Carolina, Chapel Hill | 80 | 2019-10-30 | 2021-11-10 |
| Stepped Care AiTBS 2 Depression Study (Ghent) aiTBS, CCT, SSRI - Depressive Disorder, Major, Treatment Resistant Depression | Not applicable | Completed | University Hospital, Ghent | 68 | 2017-10-05 | 2024-09-19 |
| Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients Cognitive processing therapy, Sertraline, Placebo Control - Psychologic Manipulation | Phase 1 | Completed | British University In Egypt | 150 | 2016-01-01 | 2021-04-01 |
| Success of Inferior Alveolar Nerve Block in Women Taking Selective Serotonin Reuptake Inhibitors selective serotonin reuptake inhibitor - Local Anesthesia | Completed | Isfahan University of Medical Sciences | 90 | 2015-06-01 | 2019-02-15 | |
| Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disorder Vortioxetine 10-20 mg, Placebo, SSRI - Major Depressive Disorder | Phase 3 | Completed | H. Lundbeck A/S | 151 | 2014-10-01 | 2017-05-24 |
| The ISLAND Study: InSuLa Assessed Needs for Depression Selective serotonin re-uptake inhibitor, Cognitive Behavioral Therapy, Combination treatment (SSRI + CBT) - Depression | Phase 4 | Completed | Emory University | 77 | 2014-09-01 | 2020-11-05 |
| CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients Cognitive behavioral therapy, SSRI - Depression, Epilepsy, Temporal Lobe | Not applicable | Completed | El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez | 15 | 2014-08-01 | 2015-03-30 |
| Trial of Sertraline Versus Cognitive Behaviour Therapy for Generalised Anxiety Sertraline, Cognitive Behavioural Therapy - Generalised Anxiety Disorder | Phase 4 | Terminated | University College, London | 5 | 2014-08-01 | 2016-07-11 |
| Mechanism of tDCS-induced Learning Enhancement - the Role of Serotonin tDCS, Citalopram, sham-tDCS + placebo - Healthy Young and Older Adults | Phase 1 | Completed | Charite University, Berlin, Germany | 40 | 2014-04-01 | 2021-05-12 |
| Negative Valence Brain Targets and Predictors of Anxiety and Depression Treatment SSRI, CBT - Internalizing Psychopathologies (IPs) Depression and Anxiety | Phase 4 | Completed | University of Illinois at Chicago | 271 | 2013-12-13 | 2018-10-11 |
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Depressive Disorder, Major (17) · Depression (10) · Anxiety Disorders (3) · Stress Disorders, Post-Traumatic (3) · Depressive Disorder (2) · Phobia, Social (2) · Stroke (2) · Adjustment Disorders (1) · Alzheimer Disease (1) · Bipolar Disorder (1) · Borderline Personality Disorder (1) · Cognitive Dysfunction (1) · Dementia (1) · Depressive Disorder, Treatment-Resistant (1) · Epilepsy (1)
Eli Lilly and Company (6) · University of Aarhus (2) · Xiaomei Shao (2) · Baker Heart Research Institute (1) · British University In Egypt (1) · Charite University, Berlin, Germany (1) · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez (1) · Emine Kanmaz (1) · Emory University (1) · Germans Trias i Pujol Hospital (1) · H. Lundbeck A/S (1) · Hadassah Medical Organization (1) · Hoffmann-La Roche (1) · Inje University (1) · Isfahan University of Medical Sciences (1)
United States (12) · China (6) · Germany (4) · Japan (4) · Belgium (3) · Mexico (3) · Slovakia (3) · Spain (3) · Australia (2) · Croatia (2) · Denmark (2) · Finland (2) · Puerto Rico (2) · Russia (2) · South Korea (2)
Xiaomei Shao, Ph.D (2) · Amani Elbarazi, Ph.D. (1) · Arieh Y Shalev, M.D. (1) · Atif Najum, MBBS, FCPS (1) · Boadie W Dunlop, MD/MS (1) · Boris Modrau, M.D. (1) · Chris Baeken, Prof. (1) · Daniel Crail-Melendez, MD (1) · Elizabeth Stringer, MD (1)
PMID 27035159, PMID 27685842, PMID 16585452, PMID 21724790, PMID 21969418, PMID 22945620, PMID 24643964, PMID 25894953, PMID 26376447, PMID 27135249, PMID 27555381, PMID 29894598, PMID 30355209, PMID 31060042, PMID 32122334, PMID 33860531, PMID 33896622, PMID 34274600, PMID 35141873, PMID 35267254, PMID 35803896, PMID 36997260, PMID 37255689, PMID 37641586, PMID 38767196, PMID 41449680, PMID 42286600
2014 (1), R01MH073719 (1), R01MH074807 (1), R01MH101497 (1), R21MH115806 (1)