11 completed, 6 unknown, 2 recruiting, 2 terminated. 24 Phase 2, 5 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 24 | Completed 11, Unknown 6, Recruiting 2, Terminated 2, Withdrawn 2, Active not recruiting 1 |
| Phase 1 | 5 | Completed 2, Unknown 2, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow sodium thiosulfate: new trials by email Literature Review of sodium thiosulfate trials Research Report on sodium thiosulfate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intralesional Injection of STS in Treatment of Calcinosis Sodium Thiosulfate (STS) - Systemic Sclerosis (SSc), Dermatomyositis | Phase 2 | Recruiting | Robyn T. Domsic, MD, MPH | 20 | 2025-03-17 | 2026-05-05 |
| Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy Sodium Thiosulfate + Mannitol - Ototoxic Hearing Loss | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 92 | 2023-02-15 | 2023-04-14 |
| STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care Sodium Thiosulfate 25% Solution for Injection - COVID-19, Virus Diseases | Phase 2 | Unknown | Hellenic Institute for the Study of Sepsis | 30 | 2022-04-01 | 2023-01-13 |
| Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin Cisplatin, Hearing Handicap Inventory for Adults - Screening, Radiation Therapy - Clinical Stage III Human Papillomavirus (HPV)-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Completed | Hyunseok Kang, MD | 16 | 2020-10-14 | 2024-06-28 |
| Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff Sodium Thiosulfate - Sodium Thiosulfate, Calcific Tendinitis | Phase 2 | Unknown | Soraia Azevedo | 80 | 2020-01-01 | 2021-09-28 |
| Sodium Thiosulfate to Preserve Cardiac Function in STEMI Sodium thiosulfate, Sodium chloride 0.9%, primary percutaneous coronary intervention - Myocardial Infarction, Heart Failure | Phase 2 | Unknown | University Medical Center Groningen | 380 | 2018-07-20 | 2021-09-09 |
| Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach. Sodium Thiosulfate Pentahydrate - Acute Coronary Syndrome | Phase 1 / Phase 2 | Completed | University Medical Center Groningen | 18 | 2017-10-06 | 2018-04-17 |
| Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis Sodium Thiosulfate - Dermatomyositis, Idiopathic Inflammatory Myopathies | Phase 2 / Phase 3 | Completed | National Institute of Environmental Health Sciences (NIEHS) | 15 | 2017-10-05 | 2024-11-26 |
| Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma Cisplatin, Sodium thiosulfate, Cytoreductive surgery - Adrenocortical Carcinoma, Peritoneal Carcinomatosis | Phase 2 | Active not recruiting | Columbia University | 30 | 2017-09-22 | 2026-05-06 |
| Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology Surgery, Cisplatin, Mitomycin C - Gastric Adenocarcinoma, Esophagogastric Junction | Phase 2 | Completed | National Cancer Institute (NCI) | 27 | 2017-06-05 | 2025-02-19 |
| Efficacy and Tolerance of Sodium Thiosulfate Injection After Ultrasound-guided Percutaneous Irrigation of Calcific Tendinopathy of the Rotator Cuff Sodium thiosulfate - Calcific Tendinitis of the Rotator Cuff | Phase 2 | Completed | Nantes University Hospital | 17 | 2015-12-02 | 2026-09-14 |
| Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Metastatic Gastric Cancer Mitomycin C, Cisplatin, Sodium Thiosulfate - Gastrointestinal Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 21 | 2014-05-08 | 2021-06-15 |
| BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain trastuzumab, carboplatin, methotrexate - Brain and Central Nervous System Tumors, Breast Cancer | Phase 1 / Phase 2 | Withdrawn | OHSU Knight Cancer Institute | 2013-10-01 | 2017-04-21 | |
| A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis Sodium thiosulfate, Placebo - Calcinosis Cutis | Phase 2 | Withdrawn | Loyola University | 2013-09-01 | 2016-11-17 | |
| Surgery and Heated Chemotherapy for Adrenocortical Carcinoma Cisplatin, Cytoreductive surgery, sodium thiosulfate - Adrenocortical Carcinoma, Peritoneal Carcinomatosis | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2013-04-12 | 2019-07-30 |
| Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis Fractionated Carbon Dioxide (FCO2) Laser, Sodium thiosulfate - Calcinosis | Phase 2 | Completed | Alison Ehrlich | 3 | 2012-08-01 | 2017-11-29 |
| Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Carboplatin, Mannitol, Melphalan - Central Nervous System Embryonal Neoplasm, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 17 | 2009-07-09 | 2021-10-26 |
| Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis 25% intravenous (IV) sodium thiosulfate - Coronary Calcification, Vascular Calcification | Phase 2 | Completed | Ramathibodi Hospital | 50 | 2008-07-01 | 2009-12-17 |
| Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Carboplatin, Mannitol, Methotrexate - Central Nervous System Lymphoma | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 81 | 2005-10-14 | 2021-09-22 |
| Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Carboplatin, Etoposide, Etoposide Phosphate - Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | OHSU Knight Cancer Institute | 33 | 2005-09-15 | 2022-03-17 |
Showing 20 of 24. Sign in to see all of them.
Calcinosis (4) · Dermatomyositis (3) · Adrenocortical Carcinoma (2) · Central Nervous System Neoplasms (2) · Drug-Related Side Effects and Adverse Reactions (2) · Glioma (2) · Mesothelioma, Malignant (2) · Peritoneal Neoplasms (2) · Acute Coronary Syndrome (1) · Adenocarcinoma (1) · Astrocytoma (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · COVID-19 (1) · Calcinosis Cutis (1)
OHSU Knight Cancer Institute (6) · Dana-Farber Cancer Institute (2) · National Cancer Institute (NCI) (2) · University Medical Center Groningen (2) · Alison Ehrlich (1) · Columbia University (1) · Hellenic Institute for the Study of Sepsis (1) · Hyunseok Kang, MD (1) · Loyola University (1) · M.D. Anderson Cancer Center (1) · Nantes University Hospital (1) · National Institute of Environmental Health Sciences (NIEHS) (1) · Ramathibodi Hospital (1) · Robyn T. Domsic, MD, MPH (1) · Soraia Azevedo (1)
United States (15) · Netherlands (2) · Canada (1) · France (1) · Greece (1) · Portugal (1) · Thailand (1)
Edward A Neuwelt (4) · David J. Sugarbaker, MD (2) · Edward A. Neuwelt, MD (2) · Jeremy L Davis, M.D. (2) · Adam I Schiffenbauer, M.D. (1) · Alison Ehrlich, MD (1) · Andrea Morris, MD (1) · Brian D. Badgwell, MD (1) · Elaine Adams, M.D. (1) · Gary Simon, MD (1) · Gulnara Mamayrova, MD (1) · Hyunseok Kang, MD (1) · Ioannis Alamanos, MD (1) · James Katz, MD (1) · Kazuki Sugahara, MD, PhD (1)
PMID 15942915, PMID 22227955, PMID 28643069, PMID 30463745, PMID 31673978, PMID 34534493
R01CA137488 (2), 2015 (1), P50AR080612 (1), R01NS044687 (1)