6 completed, 2 recruiting, 2 unknown, 2 withdrawn. 13 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Completed 6, Recruiting 2, Unknown 2, Withdrawn 2, Terminated 1 |
| Phase 2 | 5 | Completed 2, Unknown 2, Withdrawn 1 |
Follow sodium thiosulfate: new trials by email Literature Review of sodium thiosulfate trials Research Report on sodium thiosulfate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors Audiometric Test, Cisplatin, Computed Tomography - Hearing Loss, Metastatic Malignant Germ Cell Tumor | Phase 1 | Recruiting | City of Hope Medical Center | 44 | 2026-02-19 | 2026-04-17 |
| Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies Sodium Thiosulfate, 5-Fluorouracil, Oxaliplatin - Peritoneal Mesothelioma, Peritoneal Carcinomatosis | Phase 1 | Recruiting | National Cancer Institute (NCI) | 60 | 2021-10-19 | 2026-10-29 |
| Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25% - End Stage Renal Disease (ESRD) | Phase 1 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 18 | 2021-03-21 | 2023-12-12 |
| Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment DB-020, Placebo - Ototoxicity | Phase 1 | Completed | Decibel Therapeutics | 22 | 2020-02-21 | 2023-07-06 |
| Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium Thiosulfate Sodium thiosulfate - Healthy | Phase 1 | Withdrawn | Insel Gruppe AG, University Hospital Bern | 2018-12-01 | 2023-02-09 | |
| Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach. Sodium Thiosulfate Pentahydrate - Acute Coronary Syndrome | Phase 1 / Phase 2 | Completed | University Medical Center Groningen | 18 | 2017-10-06 | 2018-04-17 |
| BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain trastuzumab, carboplatin, methotrexate - Brain and Central Nervous System Tumors, Breast Cancer | Phase 1 / Phase 2 | Withdrawn | OHSU Knight Cancer Institute | 2013-10-01 | 2017-04-21 | |
| Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Carboplatin, Mannitol, Melphalan - Central Nervous System Embryonal Neoplasm, Embryonal Tumor With Multilayered Rosettes, C19MC-Altered | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 17 | 2009-07-09 | 2021-10-26 |
| Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma Extrapleural pneumonectomy (EPP), Cisplatin, gemcitabine - Malignant Pleural Mesothelioma | Phase 1 | Completed | Brigham and Women's Hospital | 141 | 2007-11-01 | 2017-01-23 |
| Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma Carboplatin, Mannitol, Methotrexate - Central Nervous System Lymphoma | Phase 1 / Phase 2 | Unknown | OHSU Knight Cancer Institute | 81 | 2005-10-14 | 2021-09-22 |
| Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors Carboplatin, Etoposide, Etoposide Phosphate - Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma | Phase 1 / Phase 2 | Completed | OHSU Knight Cancer Institute | 33 | 2005-09-15 | 2022-03-17 |
| Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors filgrastim, acetylcysteine, carboplatin - Bone Marrow Suppression, Brain and Central Nervous System Tumors | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2004-12-01 | 2017-04-21 |
| Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma Cisplatin, Sodium Thiosulfate - Pleural Mesothelioma, Malignant Pleural Mesothelioma | Phase 1 | Completed | Dana-Farber Cancer Institute | 70 | 1999-08-01 | 2014-03-27 |
Astrocytoma (2) · Central Nervous System Neoplasms (2) · Drug-Related Side Effects and Adverse Reactions (2) · Hearing Loss (2) · Medulloblastoma (2) · Mesothelioma, Malignant (2) · Oligodendroglioma (2) · Acute Coronary Syndrome (1) · Appendiceal Neoplasms (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Colorectal Neoplasms (1) · Familial ependymoma (1) · Gastrointestinal Neoplasms (1) · Glioma (1)
OHSU Knight Cancer Institute (5) · Brigham and Women's Hospital (1) · City of Hope Medical Center (1) · Dana-Farber Cancer Institute (1) · Decibel Therapeutics (1) · Insel Gruppe AG, University Hospital Bern (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · National Cancer Institute (NCI) (1) · University Medical Center Groningen (1)
United States (9) · Australia (1) · Canada (1) · Netherlands (1)
Edward A Neuwelt (3) · Edward A. Neuwelt, MD (2) · Alex Chehrazi-Raffle (1) · Alp Sener, Dr. (1) · Andrew M Blakely, M.D. (1) · David J. Sugarbaker, MD (1) · Dominik Uehlinger, Prof Dr.med. (1) · Pablo LaPuerta (1) · Pim van der Harst, Professor (1) · Raphael Bueno, MD (1)
P30CA033572 (1), R01CA137488 (1), R01NS044687 (1)