74 completed, 15 recruiting, 11 terminated, 9 unknown. 89 Not applicable, 15 Phase 2, 15 Phase 3, 7 Phase 1, 4 Phase 4.
Follow Sham treatment: new trials by email Literature Review of Sham treatment trials Research Report on Sham treatment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Low-thermal Argon Plasma Devitalization for the Treatment of CIN 2 Versus Standard of Active Surveillance Treatment with low-thermal argon plasma devitalization, Sham treatment - Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Cervical Intraepithelial Neoplasia Grade 2 | Not applicable | Recruiting | University Hospital Tuebingen | 264 | 2026-09-24 | 2026-10-01 |
| Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation Transcranial alternating current stimulation (tACS), Sham treatment - Stroke, Cerebrovascular Accident (CVA) | Phase 1 / Phase 2 | Not yet recruiting | Vrije Universiteit Brussel | 120 | 2026-09-01 | 2026-05-29 |
| Acute Effects of Cervical Manual Therapy on Eye Blood Flow Cervical Manual Therapy, Sham Treatment - Chronic Mechanical Neck Pain | Not applicable | Completed | Yuzuncu Yil University | 96 | 2026-08-12 | 2026-09-16 |
| Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Hyperbaric oxygen therapy, SHAM treatment - Chronic Fatigue Syndrome, ME/CFS | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 74 | 2026-07-19 | 2026-08-21 |
| MacuTherm Performance Study in Patients With iAMD photothermal therapy, Sham treatment - Intermediate AMD | Not applicable | Recruiting | OD-OS MacuTherm GmbH | 240 | 2026-05-29 | 2026-10-21 |
| Ultrasound-Guided Nerve Hydrodissection for Diabetic Lower Limb Entrapment Neuropathy Ultrasound-guided nerve hydrodissection treatment, Sham treatment - Diabetic Peripheral Neuropathy, Entrapment Neuropathy | Not applicable | Recruiting | Chongqing Medical University | 266 | 2026-05-20 | 2026-06-17 |
| Low-level Laser Therapy in Pain and Perineal Healing in the Immediate Postpartum Period: a Randomized Clinical Trial. low-level laser therapy, Sham treatment - Pain, Perineal Healing | Not applicable | Not yet recruiting | Instituto Materno Infantil Prof. Fernando Figueira | 206 | 2026-04-01 | 2026-03-18 |
| iNO300 Therapy in Critically Ill Patients With Pneumonia High dose inhaled nitric oxide, Sham treatment, standard therapy - Critical Illness, Pneumonia | Early Phase 1 | Recruiting | Massachusetts General Hospital | 34 | 2026-02-23 | 2026-05-22 |
| Effect of Subthreshold Stimulation on Fatigue in Rheumatoid Arthritis Subthreshold stimulation, Sham treatment - Rheumatoid Arthritis (RA) | Not applicable | Not yet recruiting | Beni-Suef University | 84 | 2026-02-15 | 2026-01-27 |
| The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial Pain Dry Needling, Sham Treatment - Trigger Point in Trapezius Muscle | Not applicable | Recruiting | Beth Israel Deaconess Medical Center | 70 | 2026-02-01 | 2026-02-24 |
| Shockwave Intervention for Enhanced Wound Healing in No-touch Pedicle Saphenous Vein Graft Harvesting for Coronary Artery Bypass Grafting Shockwave treatment, Sham treatment - Coronary Arterial Disease (CAD) | Not applicable | Recruiting | Medical University Innsbruck | 120 | 2025-10-03 | 2025-12-23 |
| Personalized Hypoxic-hyperoxic Preconditioning in Elderly People Sham treatment, FiO2 reduced by 20% alternating with 34% FiO2 - Preconditioning | Not applicable | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 20 | 2025-07-01 | 2026-10-21 |
| Acupuncture for Painful Temporomandibular Disorder Acupuncture, Sham treatment - Temporomandibular Disorders (TMD) | Not applicable | Not yet recruiting | Beijing Hospital of Traditional Chinese Medicine | 48 | 2025-06-01 | 2024-12-18 |
| Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine Internet Cognitive-Behavioral Therapy, Sham treatment - Depression - Major Depressive Disorder | Not applicable | Recruiting | National Science and Technology Council, Taiwan | 100 | 2025-06-01 | 2026-03-30 |
| Chronic Remote Ischemic Conditioning in Small Infarctions Associated with Stent-assisted Coiling of Unruptured Intracranial Aneurysms remote ischemic conditioning, Sham treatment - Unruptured Intracranial Aneurysm, Infarction Cerebral | Not applicable | Not yet recruiting | The First Affiliated Hospital with Nanjing Medical University | 84 | 2025-02-20 | 2025-02-13 |
| Non-invasive Brain Stimulation in Subjects with Major Depressive Disorder Active tDCS, Sham treatment - Major Depressive Disorder (MDD) | Not applicable | Not yet recruiting | Carmen Concerto | 105 | 2025-01-02 | 2024-12-03 |
| RTMS for the Treatment of Post-COVID Associated Affective Symptoms repeated transcranial magnetic stimulation, sham treatment - Post COVID -19 Depression | Not applicable | Recruiting | Flurin Cathomas | 52 | 2024-11-14 | 2024-12-04 |
| Comparison of Ultrasound-guided Electrolysis Therapy vs. Sham Electrolysis in Patients With Patellar Tendinopathy: A Prospective Randomized Study Including MRI and Shear-wave Ultrasound Elastography Imaging Ultrasound guided electrolysis therapy, Sham Electrolysis - Patellar Tendinopathy / Jumpers Knee | Not applicable | Enrolling by invitation | Gymna Uniphy | 74 | 2024-10-29 | 2025-04-30 |
| Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD The Thermage FLX System, Sham treatment - Dry Eye Syndromes, Meibomian Gland Dysfunction | Not applicable | Recruiting | The University of Hong Kong | 112 | 2024-10-22 | 2026-04-27 |
| Effectiveness of the Fascial Distortion Model in Temporomandibular Disorders: A Randomized Sham-controlled Trial Fascial Distortion Model, Sham treatment - Temporomandibular Disorders (TMD), Manual Therapy | Not applicable | Recruiting | Karabuk University | 30 | 2024-10-03 | 2026-08-05 |
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Pain (9) · Attention Deficit Disorder with Hyperactivity (4) · Depression (4) · Dry Eye Syndromes (4) · Erectile Dysfunction (4) · Fibromyalgia (4) · Meibomian Gland Dysfunction (4) · Ankle Injuries (3) · Healthcare-Associated Pneumonia (3) · Low Back Pain (3) · Pain, Postoperative (3) · Stress Disorders, Post-Traumatic (3) · Stroke (3) · Chronic Pain (2) · Critical Illness (2)
Hisamitsu Pharmaceutical Co., Inc. (6) · Tomsk National Research Medical Center of the Russian Academy of Sciences (5) · University of Michigan (5) · Brainsway (4) · Noven Therapeutics (3) · Ulthera, Inc (3) · University of California, San Diego (3) · Assaf-Harofeh Medical Center (2) · Initia (2) · Mansoura University (2) · Noven Pharmaceuticals, Inc. (2) · The First Affiliated Hospital with Nanjing Medical University (2) · University of Miami (2) · University of Minnesota (2) · Aston University (1)
United States (67) · Canada (10) · Israel (8) · Germany (7) · Russia (6) · Austria (4) · China (4) · Italy (4) · Turkey (Türkiye) (4) · Brazil (3) · Australia (2) · Egypt (2) · Hong Kong (2) · Mexico (2) · South Korea (2)
Kenichi Furuta (2) · Nikolay O. Kamenshchikov (2) · Abraham Zangen, PhD (1) · Abraham Zangen, Prof (1) · Adam K Koebel, BSc (1) · Ahmed A. Shokeir (1) · Ahmed Elkashef (1) · Ahmed Elshal (1) · Ahmed Mosbah (1) · Amanda Yunker, D.O. (1) · Amish Raval, MD (1) · Anders Kjellberg, MD, PhD (1) · Ashley Mohan, DO (1) · Avraham Zangen, PhD (1) · Aytekin Oto, MD (1)
PMID 18311814, PMID 10619108, PMID 11535445, PMID 16153272, PMID 17062241, PMID 17855614, PMID 18164469, PMID 18312050, PMID 19501658, PMID 19706829, PMID 19790053, PMID 19849639, PMID 20451317, PMID 20506181, PMID 20625364, PMID 20973706, PMID 21385086, PMID 22008059, PMID 23178541, PMID 23298885, PMID 23554844, PMID 23927552, PMID 24016492, PMID 24084497, PMID 24249997, PMID 24579210, PMID 25487690, PMID 25642956, PMID 25847552, PMID 26194634, PMID 26225500, PMID 27143533, PMID 27353237, PMID 28329131, PMID 28530451, PMID 29162313, PMID 29494898, PMID 29734566, PMID 31109199, PMID 31212388, PMID 31263727, PMID 31526071, PMID 31581800, PMID 31693083, PMID 32380442, PMID 33326711, PMID 33664879, PMID 33717552, PMID 33989382, PMID 34274108
2009 (1), K01AT001111 (1), R01DK042822 (1), R21MH098174 (1), R33AT012284 (1), R61AT010712 (1)