51 completed, 18 recruiting, 10 unknown, 7 terminated. 84 Not applicable, 5 Phase 3, 4 Phase 2, 3 Phase 1, 3 Phase 4.
Follow this drug Literature Review of Sham device trials Research Report on Sham device
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoperative Application of Cold Atmospheric Plasma to Prevent Postoperative Wound Complications in the Inguinal Region of High-risk Patients With Peripheral Arterial Occlusive Disease Cold atmospheric plasma, Sham device - Peripheral Occlusive Disease, Wound Healing | Not applicable | Not yet recruiting | Ursula Werra | 214 | 2026-11-01 | 2026-05-06 |
| Transcranial Photobiomodulation for Bipolar Depression Vielight Neuro Rx Gamma, Sham Device - Bipolar, Bipolar Disorder (BD) | Not applicable | Not yet recruiting | Vielight Inc. | 40 | 2026-07-01 | 2026-04-03 |
| A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness Sham Device, Auricular transcutaneous vagus nerve stimulation - Chronic Dizziness, Persistent Postural Perceptual Dizziness | Not applicable | Enrolling by invitation | Mayo Clinic | 60 | 2026-03-23 | 2026-10-19 |
| Synchronization of Theta to Influence Memory Sham device, STARSTIM Device in-phase, STARSTIM Device anti-phase - Cognitive Control, Memory | Not applicable | Recruiting | Florida International University | 90 | 2026-03-13 | 2026-08-27 |
| Short and Long-term Responses of PD Symptoms to Earstim EarStim, Sham device, EarStim + Standard of care (SOC) - PARKINSON DISEASE (Disorder) | Not applicable | Recruiting | Stoparkinson Healthcare Systems LLC | 90 | 2026-03-12 | 2026-04-23 |
| Repeated Low-Level Red-Light Therapy in Dry Age-Related Macular Degeneration RLRL device, Sham device - AMD - Age-Related Macular Degeneration | Not applicable | Not yet recruiting | The Hong Kong Polytechnic University | 94 | 2026-01-26 | 2026-02-13 |
| Near-infrared Light Therapy Device for Mild-Moderate Alzheimer's Disease (NirsCure-03A) NirsCure 6000, Sham Device - Alzheimer s Disease | Phase 3 | Recruiting | Danyang Huichuang Medical Equipment Co., Ltd. | 320 | 2025-12-10 | 2026-09-22 |
| Noninvasive Therapy for Tinnitus Cold pack-delivered mild therapeutic hypothermia, Sham device - Tinnitus, Tinnitus, Subjective | Not applicable | Recruiting | Restorear Devices LLC | 40 | 2025-11-24 | 2026-07-09 |
| Brain Stimulation in Long COVID Repetitive Transcranial Magnetic Stimulation, Sham device - Long COVID, PASC Post Acute Sequelae of COVID 19 | Not applicable | Recruiting | Amsterdam UMC, location VUmc | 66 | 2025-11-17 | 2025-12-19 |
| Ultrasound Guided Transcutaneous Pulsed Radiofrequency for Cervical Radiculopathy true transcutaneous pulsed radiofrequency, Sham device - Cervical Radiculopathy | Not applicable | Recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 32 | 2025-11-01 | 2026-05-13 |
| Evaluation of Cerogrin for Auricular Vagus Nerve Stimulation in Vascular Dementia or Vascular Mild Cognitive Impairment Cerogrin, Sham Device - Vascular Dementia, Mild Cognitive Impairment | Not applicable | Active not recruiting | Neurogrin Inc. | 24 | 2025-10-15 | 2026-09-18 |
| The Lilac Device Trial - IMPACT: A Clinical Investigation on IMproving Peripheral Neuropathy Induced by Chemotherapy With Advanced Compression Technology - A Safety and Efficacy Study The Lilac Device, Sham device - Chemotherapy Induced Peripheral Neuropathy (CIPN) | Not applicable | Recruiting | Luminate Medical, Inc. | 142 | 2025-10-03 | 2026-06-10 |
| TaVNS for Acute Intracerebral Hemorrhage transcutaneous auricular vagus nerve stimulation device, Sham device - Intracerebral Hemorrhage | Not applicable | Recruiting | Beijing Tiantan Hospital | 186 | 2025-09-15 | 2026-01-15 |
| Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Anxiety in Adolescents Modius Calm, Sham device - General Anxiety Disorder | Not applicable | Completed | Neurovalens Ltd. | 60 | 2025-09-08 | 2026-07-01 |
| Extracorporeal Shockwave Therapy (ESWT) for the Management of Stress Fractures and High-grade Bone Stress Injuries (BSIs) Extracorporeal shockwave treatment (ESWT)., Sham Device - Bones Stress Injury, Bone Stress Fracture | Not applicable | Recruiting | University of California, Los Angeles | 140 | 2025-05-01 | 2026-09-11 |
| Impact of Muscle Training Device on Non-Severe OSA DidgeriTU, Sham device - OSA, Obstructive Sleep Apnea | Not applicable | Recruiting | Thammasat University Hospital | 76 | 2025-05-01 | 2026-01-21 |
| Initial Pilot Study to Evaluate the Safety and Temporary Symptom Improvement Efficacy of CKD-981 CKD-981(1), CKD-981(2), Sham device - Knee Osteoarthritis | Phase 2 | Completed | Chong Kun Dang Pharmaceutical | 100 | 2025-04-28 | 2026-04-13 |
| Fractional Bipolar Radiofrequency Therapy VS Sham for Treatment of Vaginal Laxity in Premenopausal Women Fractional bipolar radiofrequency, Sham device - Vaginal Laxity | Not applicable | Not yet recruiting | Mahidol University | 56 | 2025-04-01 | 2025-03-17 |
| Efficacy and Safety of the Soricle for Subjective Tinnitus Relief Sham Device, tVNS Device, tVNS + Sound Stimulation Device - Tinnitus, Subjective Tinnitus | Not applicable | Completed | Neurive Co.,Ltd. | 36 | 2025-03-10 | 2026-04-23 |
| Impact of Red Light Therapy on Alleviating Visual Fatigue in Presbyopes RLRL device, sham device - Asthenopia, Visual Fatigue | Not applicable | Completed | The Hong Kong Polytechnic University | 66 | 2025-02-10 | 2025-09-24 |
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Depression (7) · Depressive Disorder, Major (5) · Pain (5) · Cognitive Dysfunction (4) · Tinnitus (4) · Alopecia (3) · Irritable Bowel Syndrome (3) · Pain, Postoperative (3) · Peripheral Nervous System Diseases (3) · Atrial Fibrillation (2) · Depressive Disorder (2) · Diabetic Neuropathies (2) · Fatigue (2) · Fibromyalgia (2) · Glomerulosclerosis, Focal Segmental (2)
Icahn School of Medicine at Mount Sinai (3) · Mayo Clinic (3) · Neurovalens Ltd. (3) · Northwell Health (3) · Northwestern University (3) · The First Affiliated Hospital of Soochow University (3) · The Hong Kong Polytechnic University (3) · University of California, Los Angeles (3) · OrthoAccel Technologies Inc. (2) · University of Toledo Health Science Campus (2) · University of Wisconsin, Madison (2) · VA Office of Research and Development (2) · Amsterdam UMC, location VUmc (1) · Beijing Tiantan Hospital (1) · Cairo University (1)
United States (58) · China (8) · South Korea (7) · Canada (4) · Taiwan (3) · Denmark (2) · Hong Kong (2) · India (2) · Thailand (2) · Turkey (Türkiye) (2) · Belgium (1) · France (1) · Germany (1) · Ireland (1) · Italy (1)
Sai Sailesh Kumar Goothy (2) · Aksone Nouvong, DPM (1) · Alfred-Marc Iloreta, MD (1) · Amar Miglani, M.D. (1) · Amy VandenBerg (1) · Ann G Taylor, EdD, RN (1) · Annalise Sorensen (1) · Ari Aal, DO (1) · Bashar Kahaleh, MD (1) · Bobby Tay, MD (1) · Christina Lewicky-Gaupp, M.D. (1) · Christopher B Cooper, M.D. (1) · Colton Clayton, Au.D., Ph.D. (1) · Connie A Rey (1)
PMID 38724717, PMID 19093136, PMID 20584127, PMID 21461326, PMID 22431712, PMID 24508614, PMID 24782387, PMID 25419887, PMID 26340453, PMID 26356811, PMID 27567072, PMID 29408585, PMID 29955803, PMID 31603076, PMID 33635894, PMID 34608032, PMID 34629323, PMID 34647191, PMID 36162945, PMID 36588397, PMID 36870045, PMID 37339352, PMID 38743564, PMID 39328083, PMID 39706483, PMID 40392172, PMID 40518459, PMID 40931367, PMID 41060661, PMID 41114984, PMID 41443523, PMID 41554532, PMID 42046494, PMID 42764112
R01DK131091 (2), K23DK125266 (1), R01AG057693 (1), R43DC022211 (1), R43DK088634 (1)