41 completed, 15 unknown, 11 recruiting, 8 not yet recruiting. 57 Not applicable, 9 Phase 2, 9 Phase 3, 5 Phase 1, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| Brief Bronchial Suction for Lung Collapse During Uniportal VATS bronchial suction, Sham Control - Lung Collapse, One-lung Ventilation | Not applicable | Not yet recruiting | Mahidol University | 100 | 2026-11-01 | 2026-10-07 |
| RELIEVE-HFrEF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure With Reduced EF Implantation of the V-Wave Interatrial shunt, Sham (no implant) - Heart Failure and Reduced Ejection Fraction, Heart Failure Chronic | Not applicable | Not yet recruiting | V-Wave Ltd | 250 | 2026-09-30 | 2026-07-10 |
| AVE-Neurofeedback for Academic Anxiety and Divergent Thinking Audiovisual Entrainment Neurofeedback (AVE-NFB), Neurofeedback Only, Audiovisual Entrainment - Academic Anxiety, Test Anxiety | Not applicable | Recruiting | Daniswara Raditya Suprapto | 240 | 2026-09-04 | 2026-09-02 |
| Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults Exercise, Sham Control - Frailty Syndrome, Older Adults | Not applicable | Recruiting | Taipei Medical University | 30 | 2026-08-19 | 2026-10-05 |
| Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly Catheter Ablation, Sham Control - Atrial Fibrillation (AF) | Not applicable | Recruiting | Beijing Anzhen Hospital | 136 | 2026-07-01 | 2026-07-06 |
| Safety and Efficacy Study of Novel Gene Therapy AGX-08 for Geographic Atrophy AGX-08-L, AGX-08-H, AGX-08-S - Geographic Atrophy | Early Phase 1 | Not yet recruiting | Zhongmou Therapeutics | 24 | 2026-07-01 | 2026-07-31 |
| The REVIVE Pivotal Study Ryme TLD, Sham Control - COPD (Chronic Obstructive Pulmonary Disease), COPD Exacerbations | Not applicable | Not yet recruiting | Ryme Medical, Inc. | 300 | 2026-06-01 | 2026-05-05 |
| Electromyographic Biofeedback Therapy in Patients With Dyssynergic Defecation Game-Based Electromyographic (EMG) Biofeedback Therapy, Sham Control - Defecation Disorder | Not applicable | Recruiting | Kocaeli University | 36 | 2026-03-31 | 2026-08-07 |
| Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction Right Greater Splanchnic Nerve (GSN) ablation, Sham Control - Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Not yet recruiting | Axon Therapies, Inc. | 50 | 2026-03-01 | 2026-02-11 |
| Improving Speech in Noise Perception for Individuals With Age-related Hearing Loss transcutaneous auricular vagus nerve stimulation, Sham Control - Presbycusis | Not applicable | Completed | University of Florida | 36 | 2025-12-01 | 2026-10-20 |
| Development of a Novel Multidimensional Therapeutic Intervention Protocol for MCI Olfactory stimulation, Temporal Interference,TI, Olfactory-TI Stimulation - MCI-AD, Early Stage Alzheimer's Disease | Not applicable | Not yet recruiting | Yuan Shen | 300 | 2025-10-01 | 2025-09-29 |
| Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant Bradycardia Cardioneuroablation, Sham Control - Symptomatic Bradycardia, Autonomic Nervous System Diseases | Not applicable | Recruiting | Beijing Anzhen Hospital | 188 | 2025-08-01 | 2026-03-13 |
| Photobiomodulation in Radiodermatitis in People With Breast Cancer Photobiomodulation, Sham Control - Breast Cancer, Radio Dermatitis | Not applicable | Not yet recruiting | Instituto Nacional de Cancer, Brazil | 148 | 2025-05-01 | 2025-05-25 |
| Standard Urotherapy for Dysfunctional Voiding in Children Standard urotherapy (SUT) alone., Sham control - Dysfunctional Voiding, Medical Treatment | Not applicable | Completed | Tanta University | 140 | 2025-02-26 | 2026-08-03 |
| Heat thErapy And mobiLity in COVID-19 Survivors Heat therapy, Sham Control, Walking - Long COVID | Not applicable | Recruiting | University of Nebraska | 99 | 2025-01-16 | 2026-09-28 |
| Effects of Exposure to a Single-electrode Electroencephalography-guided Binaural Beat Audio Track on Sustained Attention and Subjective Well-being Among Healthy Adults EEG-Guided Binaural Beat Audio, Sham Control - Psychomotor Speed, Sustained Attention | Not applicable | Completed | Texas Tech University Health Sciences Center | 25 | 2024-08-16 | 2025-09-10 |
| The METRIC Study Protocol lumbar spinal manipulative therapy, sham spinal manipulative therapy, full spine spinal manipulative therapy - Chronic Low-back Pain | Not applicable | Recruiting | Université du Québec à Trois-Rivières | 112 | 2023-10-25 | 2023-12-04 |
| Effects of Intravascular Laser Irradiation of Blood for Mitochondral Dysfunction in Cerebral Ischemic Stroke ILIB, Sham Control - Ischemic Stroke | Not applicable | Completed | Tri-Service General Hospital (TSGH) | 8 | 2023-08-01 | 2025-04-17 |
| Contingency Management for Drug Use: Does Age Matter? DynamiCare app (app-based contingency management), Sham control - Opioid Use Disorder, Methamphetamine Abuse | Not applicable | Completed | Wake Forest University Health Sciences | 62 | 2023-05-01 | 2026-08-18 |
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Hypertension (4) · Ischemic Stroke (4) · Tobacco Use Disorder (4) · Heart Failure (3) · Stroke (3) · Brain Injuries, Traumatic (2) · Diabetes Mellitus, Type 2 (2) · Geographic Atrophy (2) · Hyperthermia (2) · Inflammation (2) · Intervertebral Disc Degeneration (2) · Opioid-Related Disorders (2) · Post-Acute COVID-19 Syndrome (2) · Pulmonary Disease, Chronic Obstructive (2) · Respiratory Tract Infections (2)
University of California, Los Angeles (4) · Novartis Pharmaceuticals (3) · Seoul National University Hospital (3) · Arizona State University (2) · Axon Therapies, Inc. (2) · Beijing Anzhen Hospital (2) · University of Florida (2) · Wake Forest University Health Sciences (2) · Ablative Solutions, Inc. (1) · Ariel University (1) · Baker Heart and Diabetes Institute (1) · BrainsGate (1) · Broncus Technologies (1) · Chang Gung Memorial Hospital (1) · Children's ENT of San Diego, Inc. (1)
United States (32) · Canada (8) · Germany (8) · United Kingdom (7) · Australia (6) · South Korea (6) · Brazil (5) · China (5) · Spain (5) · Taiwan (5) · Czechia (4) · France (4) · Singapore (4) · Belgium (3) · Israel (3)
Alain Ades, MD (1) · Alfonso Torquati, MD (1) · Anke Bergmann, PhD (1) · Ariel Zucher, PhD (1) · Ariel Zucker, PhD (1) · Atul Pathak, Prof. (1) · Carl LeBel, PhD (1) · Changsheng Ma, Prof. (1) · Charles Filipi, MD (1) · Charles Lightdale, MD (1) · Chih-Ming Cheng, M.D. (1) · Christian Lamer, MD (1) · Christian Seiler, Prof (1) · Christopher Centeno, MD (1)
PMID 16530506, PMID 16952539, PMID 17294322, PMID 17368232, PMID 20179692, PMID 21214899, PMID 21907863, PMID 22908836, PMID 25181050, PMID 25835112, PMID 28059942, PMID 29895590, PMID 30180887, PMID 32958438, PMID 33397772, PMID 33739123, PMID 33893763, PMID 34129127, PMID 34402352, PMID 34806762, PMID 36349701, PMID 38020175, PMID 38211934, PMID 38321811, PMID 38968979, PMID 39231380, PMID 39356530, PMID 39526682, PMID 40315243, PMID 40709601, PMID 41360993, PMID 42518791
2018 (1), R01AG073634 (1), R01AG089307 (1)