12 completed. 12 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 12 |
| Phase 2 | 4 | Completed 4 |
Follow Saline Solution, Hypertonic: new trials by email Literature Review of Saline Solution, Hypertonic trials Research Report on Saline Solution, Hypertonic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Implications of Post-Operative Irrigation Fluid's Osmolarity on the Recurrence of Non-Muscle Invasive Bladder Cancer Following Transurethral Resection Continuous Bladder Irrigation with distilled water, Continuous Bladder Irrigation with normal saline, Continuous Bladder Irrigation with hypertonic saline - Bladder (Urothelial, Transitional Cell) Cancer, Nonmuscle Invasive Bladder Cancer | Phase 2 / Phase 3 | Completed | Ain Shams University | 150 | 2024-10-01 | 2025-12-29 |
| Hypertonic Saline Therapy in Ambulatory Heart Failure Unit. Hypertonic saline solution plus intravenous furosemide, Intravenous furosemide - Heart Failure | Phase 3 | Completed | Puerta de Hierro University Hospital | 167 | 2021-01-01 | 2023-11-09 |
| Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR) Hypertonic saline, Carbocysteine 750 MG - Bronchiectasis | Phase 3 | Completed | Belfast Health and Social Care Trust | 288 | 2018-06-27 | 2025-05-02 |
| Treating Brain Swelling in Pediatric Cerebral Malaria Mechanical ventilation, Hypertonic saline - Malaria, Cerebral | Phase 3 | Completed | Michigan State University | 57 | 2018-01-08 | 2025-03-17 |
| Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function Following Cardiac Surgery Ringer Lactate (10ml/kg) fluid expansion, Hypertonic saline (3ml/kg) fluid expansion - Right Ventricular Impaired Function, Hypovolemia | Phase 3 | Completed | University Hospital, Grenoble | 30 | 2016-08-01 | 2018-04-30 |
| Saline Hypertonic in Preschoolers + CT Active Treatment Group 7% Hypertonic Saline, Control Group 0.9% Isotonic Saline - Cystic Fibrosis | Phase 2 / Phase 3 | Completed | University of Washington, the Collaborative Health Studies Coordinating Center | 116 | 2015-03-24 | 2024-03-12 |
| Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis 3% Saline, 0.9% Normal Saline - Acute Viral Bronchiolitis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 778 | 2012-10-01 | 2014-07-28 |
| Safety and Efficacy of Low Dose Hypertonic Saline Solution and High Dose Furosemide for Congestive Heart Failure furosemide and hypertonic saline solution, furosemide - Congestive Heart Failure, Renal Insufficiency | Phase 3 | Completed | Aspirus Heart and Vascular Institute-Research and Education | 50 | 2009-11-01 | 2012-02-09 |
| The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis hypertonic saline (7 %) and isotonic saline (0.9%) - Cystic Fibrosis | Phase 3 | Completed | The Hospital for Sick Children | 20 | 2008-03-01 | 2013-09-02 |
| Nebulized Hypertonic Saline for Bronchiolitis Nebulized 3% saline, Nebulized 0.9% saline - Bronchiolitis | Phase 2 / Phase 3 | Completed | Children's Hospital Los Angeles | 447 | 2008-02-01 | 2024-11-05 |
| The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants. 3 % hypertonic saline - Bronchiolitis | Phase 2 / Phase 3 | Completed | Sheikh Khalifa Medical City | 2003-11-01 | 2007-05-07 | |
| The Effects of Long Term Inhalation of Hypertonic Saline in Subjects With Cystic Fibrosis hypertonic saline - Cystic Fibrosis | Phase 3 | Completed | Royal Prince Alfred Hospital, Sydney, Australia | 164 | 2000-09-01 | 2006-10-09 |
Bronchiolitis (3) · Cystic Fibrosis (3) · Heart Failure (2) · Respiratory Tract Diseases (2) · Bronchial Diseases (1) · Bronchiectasis (1) · Bronchiolitis, Viral (1) · Cardio-Renal Syndrome (1) · Coma (1) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Hypovolemia (1) · Lung Diseases (1) · Lung Diseases, Obstructive (1) · Malaria, Cerebral (1)
Ain Shams University (1) · Aspirus Heart and Vascular Institute-Research and Education (1) · Assistance Publique - Hôpitaux de Paris (1) · Belfast Health and Social Care Trust (1) · Children's Hospital Los Angeles (1) · Michigan State University (1) · Puerta de Hierro University Hospital (1) · Royal Prince Alfred Hospital, Sydney, Australia (1) · Sheikh Khalifa Medical City (1) · The Hospital for Sick Children (1) · University Hospital, Grenoble (1) · University of Washington, the Collaborative Health Studies Coordinating Center (1)
Canada (3) · France (3) · United States (3) · Spain (2) · Australia (1) · Belgium (1) · Denmark (1) · Egypt (1) · Italy (1) · Malawi (1) · Netherlands (1) · United Arab Emirates (1) · United Kingdom (1)
Brian A Kuzik, MD, FRCP (1) · Felix Ratjen, MD (1) · Felix Ratjen, MD, PhD, FRCPC (1) · German Larrain, MD (1) · Harm Tiddens, MD, PhD (1) · J. Stuart Elborn (1) · Margaret Rosenfeld, MD, MPH (1) · Marta Cobo Marcos, MD (1) · Peter T P Bye, PhD (1) · Richard S Engelmeier, MD (1) · Stephanie Davis, MD (1) · Stephen Stick, MD, PhD (1) · Susan Wu, MD (1) · Terrie E Taylor, DO (1) · Vincent Gajdos, MD, PhD (1)
PMID 37319354, PMID 16421364, PMID 20435858, PMID 24862623, PMID 28586918, PMID 34020114, PMID 35286860
U01AI126610 (1)