16 completed, 4 terminated, 2 recruiting, 2 withdrawn. 12 Not applicable, 6 Phase 2, 3 Phase 1, 3 Phase 4, 1 Early Phase 1.
Follow Room air: new trials by email Literature Review of Room air trials Research Report on Room air
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia Oxygen, Room air - Pulmonary Hypertension | Phase 1 / Phase 2 | Withdrawn | Duke University | 2026-07-01 | 2026-09-03 | |
| A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections Pro-Nox Nitrous Oxide/Oxygen Delivery System, Standard Care for Bladder Botox Injection, Sham Mask - Overactive Bladder, Neurogenic Bladder | Phase 4 | Not yet recruiting | TriHealth Inc. | 96 | 2026-02-01 | 2026-02-04 |
| Maternal Oxygen Supplementation for Intrauterine Resuscitation Maternal oxygen supplementation, Room air - Fetal Distress, Fetal Hypoxia | Not applicable | Recruiting | Washington University School of Medicine | 2252 | 2023-05-22 | 2026-08-10 |
| Effect of Nitrous Oxide on Aggression. Nitrous oxide, Room Air - Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 50 | 2022-09-06 | 2025-03-27 |
| Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise Exercise, Ozone, Room air - Ozone Exposure During Rest and Exercise | Not applicable | Completed | University of British Columbia | 20 | 2022-08-18 | 2025-04-13 |
| Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease? Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air - OSA, Sleep Apnea | Phase 1 | Completed | University of California, San Diego | 182 | 2021-10-08 | 2026-05-11 |
| The Effect of Inhaled Nitric Oxide on Deadspace in COPD Nitric Oxide, Placebo - Chronic Obstructive Pulmonary Disease | Early Phase 1 | Completed | Dr. Denis O'Donnell | 13 | 2021-09-01 | 2024-04-03 |
| Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities Room air - Perinatal Death, Respiratory Distress Syndrome, Newborn | Not applicable | Withdrawn | Loma Linda University | 2021-06-01 | 2021-08-17 | |
| The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea Oxygen, Room Air - Heart Failure, Central Sleep Apnea | Phase 3 | Terminated | Brigham and Women's Hospital | 98 | 2019-04-15 | 2023-08-01 |
| Nitrous Oxide for Analgesia During Office Urethral Bulking Nitrous Oxide + Oxygen Gas (Product), lidocaine gel 2%, Room air - Pain, Stress Incontinence, Female | Phase 4 | Terminated | Baylor Research Institute | 2 | 2019-02-15 | 2020-08-20 |
| The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia normobaric oxygen, room air - Normobaric Oxygen, Cerebral Ischemia | Not applicable | Completed | Capital Medical University | 49 | 2018-12-01 | 2020-04-08 |
| Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate No oxygen, Oxygen - Intrauterine Resuscitation | Not applicable | Completed | Washington University School of Medicine | 910 | 2018-07-15 | 2025-04-15 |
| Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury Hyperbaric Oxygen, Minimal pressure air - Brain Injury, Chronic | Phase 2 | Completed | Lindell Weaver | 49 | 2017-09-06 | 2022-08-04 |
| Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings Room air, 10L Oxygen by nonrebreather mask - Electronic Fetal Monitoring, Fetal Hypoxia | Not applicable | Completed | Washington University School of Medicine | 114 | 2016-06-01 | 2021-11-26 |
| Comparison of Pharyngeal Oxygen Delivery by Different Oxygen Masks Oxygen administration - Hypoxemia, Trauma | Completed | Oregon Health and Science University | 14 | 2015-05-01 | 2018-08-01 | |
| Investigating the Effects of Hyperoxia on Fractional Flow Reserve High Flow oxygen, Room Air - Coronary Artery Disease | Not applicable | Unknown | Bayside Health | 18 | 2014-03-01 | 2014-03-10 |
| Mechanisms of Exertional Dyspnea in Fibrotic Interstitial Lung Disease Room air, Hyperoxia - Lung; Disease, Interstitial, With Fibrosis | Not applicable | Completed | University of British Columbia | 20 | 2013-09-01 | 2016-10-12 |
| Respiratory Drive on Obstructive Apnea Rebreathing bag, Sham rebreathing, Mask - Obstructive Sleep Apnea | Not applicable | Terminated | University of Manitoba | 13 | 2013-08-01 | 2015-06-29 |
| Combination Therapy to Treat Sleep Apnea Placebo pill, Sedative, Room air - Sleep Apnea, Obstructive | Not applicable | Completed | Brigham and Women's Hospital | 22 | 2012-08-01 | 2017-03-03 |
| Normobaric Oxygen (NBO) Therapy in Acute Migraine Oxygen, Room air - Migraine | Phase 2 | Completed | Massachusetts General Hospital | 22 | 2012-07-01 | 2017-03-27 |
Showing 20 of 26. Sign in to see all of them.
Pain (3) · Sleep Apnea, Obstructive (3) · Dyspnea (2) · Fetal Hypoxia (2) · Hypertension, Pulmonary (2) · Motor Activity (2) · Agnosia (1) · Alzheimer Disease (1) · Apnea (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Brain Injury, Chronic (1) · Brain Ischemia (1) · Coronary Artery Disease (1) · Disease (1)
Washington University School of Medicine (3) · Brigham and Women's Hospital (2) · Massachusetts General Hospital (2) · University of British Columbia (2) · Baylor Research Institute (1) · Bayside Health (1) · Capital Medical University (1) · Dr. Denis O'Donnell (1) · Duke University (1) · Emory University (1) · Lindell Weaver (1) · Loma Linda University (1) · Ohio State University (1) · Oregon Health and Science University (1) · Region Skane (1)
United States (16) · Canada (4) · Australia (1) · China (1) · Germany (1) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Aneesh B Singhal, MD (2) · Daniel Edmonston, MD, MHS (1) · David A Wellman, MD (1) · Denis E O'Donnell, MD (1) · Emil Coccaro, M.D. (1) · Jeffrey Kirsch, MD (1) · Jordan A Guenette, PhD (1) · Lindell K. Weaver, MD (1) · Margaret R Hines, MD (1) · Michael Koehle, MD, PhD (1) · Natalia White, BA BMBCh (1) · Randy D Trumbower, PT, PhD (1) · Ruofan Yao, MD MPH (1) · Ulf Ekelund, MD PhD (1)
PMID 24285617, PMID 24366914, PMID 24991933, PMID 25811584, PMID 27206964, PMID 27634790, PMID 28409851, PMID 28546272, PMID 29436868, PMID 30039159, PMID 31506337, PMID 32070283, PMID 34726532, PMID 40135690, PMID 40929650, PMID 41025403
K23HD098315 (1), P50NS051343 (1), R01HD108614 (1), R01HL102321 (1), U24HL140412 (1)