5 active not recruiting, 4 recruiting, 3 unknown, 1 completed. 14 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Active not recruiting 5, Recruiting 4, Unknown 3, Completed 1, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Protons: new trials by email Literature Review of Protons trials Research Report on Protons
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial) Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) - Tuberculosis (TB) | Phase 3 | Recruiting | University College, London | 784 | 2026-10-12 | 2026-10-26 |
| Ultra-Short Regimen for Elderly DS-TB Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Not yet recruiting | Shenzhen Third People's Hospital | 300 | 2025-07-25 | 2025-07-22 |
| A PAN-USR TB Multi-Center Trial Bedaquiline (B), Sitafloxacin (S), Linezolid (L) - Pulmonary Tuberculosis | Phase 3 | Recruiting | Shenzhen Third People's Hospital | 610 | 2025-06-18 | 2025-12-01 |
| Shortened Regimen for Drug-susceptible TB in Children Isoniazid, Rifampin, Pyrazinamide - Tuberculosis, Tuberculosis, Pulmonary | Phase 3 | Recruiting | Johns Hopkins University | 860 | 2025-01-15 | 2026-07-24 |
| Efficacy and Safety of Adjuvant Docetaxel and Trastuzumab in Stage I HER2-positive Breast Cancer Paclitaxel, Trastuzumab, Docetaxel - HER2-positive Breast Cancer, Adjuvant Therapy | Phase 2 / Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 190 | 2022-01-31 | 2022-01-12 |
| Neoadjuvant Treatment Pegylated Liposomal Doxorubicin Plus Cyclophosphamide Sequential Docetaxel Plus Trastuzumab and Pertuzumab Versus Docetaxel Plus Carboplatin Combined With Trastuzumab and Pertuzumab in HER-2 Positive Breast Cancer pegylated liposomal doxorubicin (PLD), cyclophosphamide (C), trastuzumab (H) - Breast Cancer | Phase 3 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 372 | 2021-12-20 | 2024-02-02 |
| Phase III Study of 5tx vs 15tx of RT (X-rays or Protons) Including RNI in Breast Cancer Patients Proton Beam Radiation Therapy, Questionnaire Administration, X-ray Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 3 | Active not recruiting | Mayo Clinic | 146 | 2020-06-16 | 2026-01-16 |
| Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer Biospecimen Collection, Capecitabine, Carboplatin - Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 300 | 2019-06-26 | 2026-08-24 |
| Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Biospecimen Collection, Clinical Observation, Intensity-Modulated Radiation Therapy - Grade 2 Meningioma, Intracranial Meningioma | Phase 3 | Active not recruiting | NRG Oncology | 162 | 2017-09-12 | 2026-10-02 |
| PERS Genetic Model Assistant Decision-making System of Neoadjuvant Chemotherapy for Breast Cancer NVB, EPI, DDP - Breast Cancer Model, Effects of Chemotherapy | Phase 3 | Unknown | Shi Yanxia | 320 | 2016-04-01 | 2017-01-16 |
| Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer Carboplatin, Cisplatin, Durvalumab - Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7 | Phase 3 | Active not recruiting | Radiation Therapy Oncology Group | 330 | 2014-01-03 | 2026-06-08 |
| Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis, Photon Beam Radiation Therapy - Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7, Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 440 | 2013-08-26 | 2026-08-21 |
| Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base Carbon ion, Protons - Chordoma, Tumor | Phase 3 | Unknown | Heidelberg University | 319 | 2010-07-01 | 2010-08-17 |
| Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO) Nevirapine based therapy, Efavirenz based therapy, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Tuberculosis, Aids | Phase 2 / Phase 3 | Completed | French National Agency for Research on AIDS and Viral Hepatitis | 570 | 2007-12-01 | 2012-02-15 |
Tuberculosis (3) · Tuberculosis, Pulmonary (3) · Breast Neoplasms (2) · Acquired Immunodeficiency Syndrome (1) · Carcinoma, Non-Small-Cell Lung (1) · Chordoma (1) · HIV Infections (1) · Infections (1) · Lung Diseases (1) · Meningioma (1) · Mycobacterium Infections (1) · Neoplasms (1) · Respiratory Tract Diseases (1) · Respiratory Tract Infections (1) · Squamous Cell Carcinoma of Head and Neck (1)
NRG Oncology (2) · Shenzhen Third People's Hospital (2) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Heidelberg University (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · Radiation Therapy Oncology Group (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Shi Yanxia (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University College, London (1)
United States (5) · China (4) · India (2) · Mozambique (2) · South Africa (2) · Zimbabwe (2) · Canada (1) · Germany (1) · Indonesia (1) · Japan (1) · Pakistan (1) · Saudi Arabia (1) · Uganda (1) · Zambia (1)
Carlos E. Vargas, M.D. (1) · Juergen Debus, MD PhD (1) · Maryline Bonnet, MD (1) · Michael A Vogelbaum (1) · Nicole Salazar-Austin, MD, ScM (1) · Nilesh Bhatt, MD (1) · Steven H Lin (1) · Steven J Frank (1) · Tao Pan (1) · YanXia Shi, doctor (1) · Zhongxing Liao (1)
PMID 36808186, PMID 21054824, PMID 23433590, PMID 24663014, PMID 26038418, PMID 26104205, PMID 27084653, PMID 32615102, PMID 36053506, PMID 36546625, PMID 37567554, PMID 37980911, PMID 41005671, PMID 41290309, PMID 41391462
U10CA180868 (3), R03CA188162 (1), R56DE025248 (1), U10CA021661 (1), U10CA180822 (1), U19CA021239 (1)