5 completed, 3 terminated, 1 active not recruiting, 1 not yet recruiting. 12 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 5, Terminated 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 2 | 6 | Completed 2, Terminated 2, Active not recruiting 1, Recruiting 1 |
Follow Protons: new trials by email Literature Review of Protons trials Research Report on Protons
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial of the 24-valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/Tetanus Toxoid) 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) (referred to as PCV24) (dose M), PCV24 vaccine (dose H), PCV24 vaccine (dose M) - Streptococcus Pneumoniae Infection | Phase 1 / Phase 2 | Recruiting | CanSino Biologics Inc. | 854 | 2026-05-24 | 2026-08-05 |
| Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z) - Drug Induced Liver Injury, Tuberculosis (TB) | Phase 1 | Not yet recruiting | Liaquat National Hospital & Medical College | 410 | 2025-07-01 | 2025-07-10 |
| A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer proton plus carbon ion radiotherapy - Triple Negative Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Unknown | Shanghai Proton and Heavy Ion Center | 24 | 2023-01-10 | 2023-01-20 |
| Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer Proton Beam Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration - Locally Advanced Head and Neck Squamous Cell Carcinoma, Locally Advanced Hypopharyngeal Squamous Cell Carcinoma | Phase 1 | Completed | M.D. Anderson Cancer Center | 3 | 2020-10-19 | 2024-10-29 |
| Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 124 | 2015-09-17 | 2026-05-15 |
| PK Study of Anti-TB Drugs Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) - Tuberculosis | Phase 1 | Completed | University of Oxford | 61 | 2015-07-07 | 2018-10-03 |
| Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy fulvestrant 500 mg, Docetaxel, Trastuzumab (H, 8mg/kg - HER2-positive Breast Cancer, ER-positive Breast Cancer | Phase 1 / Phase 2 | Terminated | Western Regional Medical Center | 4 | 2014-07-01 | 2018-02-20 |
| Muscle Afferent Feedback Effects in Patients With Heart Failure Muscle Contraction with Metabolite Solution Administration - Chronic Heart Failure | Phase 1 | Completed | University of Utah | 144 | 2013-09-01 | 2018-01-08 |
| Image-Guided, Intensity-Modulated Photon or Proton Beam Radiation Therapy in Treating Patients With Stage II-IIIB Non-small Cell Lung Cancer Image Guided Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Recurrent Lung Non-Small Cell Carcinoma, Stage II Non-Small Cell Lung Cancer AJCC v7 | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 146 | 2012-09-17 | 2026-09-16 |
| Proton Therapy and Bevacizumab for Primary Liver Tumors Bevacizumab, Proton Radiation Therapy - Liver Cancer, Hepatocellular Carcinoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 3 | 2007-05-01 | 2012-08-01 |
| Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer Proton Radiation Therapy, Taxol, Carboplatin - Locally Advanced Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Terminated | Loma Linda University | 28 | 1999-08-01 | 2014-05-22 |
| Proton Beam Therapy for Treatment of Hepatocellular Carcinoma Proton radiation therapy - Liver Cancer, Hepatocellular Carcinoma | Phase 1 / Phase 2 | Completed | Loma Linda University | 76 | 1998-05-01 | 2012-08-20 |
Carcinoma, Hepatocellular (2) · Carcinoma, Non-Small-Cell Lung (2) · Liver Neoplasms (2) · Tuberculosis (2) · Breast Neoplasms (1) · Carcinoma (1) · Chemical and Drug Induced Liver Injury (1) · Cholangiocarcinoma (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1) · Nasopharyngeal Carcinoma (1) · Pneumococcal Infections (1) · Triple Negative Breast Neoplasms (1)
M.D. Anderson Cancer Center (4) · Loma Linda University (2) · CanSino Biologics Inc. (1) · Liaquat National Hospital & Medical College (1) · Shanghai Proton and Heavy Ion Center (1) · University of Oxford (1) · University of Utah (1) · Western Regional Medical Center (1)
United States (8) · China (2) · Thailand (1)
Ariba Sultan (1) · Clifton D Fuller (1) · David A Bush, MD (1) · David A. Bush, MD (1) · James Welsh (1) · Jerry D Slater, MD (1) · Jerry D. Slater, MD (1) · Jordan Waypa, FNP (1) · Markus Amann, PhD (1) · Sunil Krishnan, MD (1) · Zhiqiang Xie, Master (1) · Zhongxing Liao (1)
PMID 15508084, PMID 21264826, PMID 26400476, PMID 31996395, PMID 33051340, PMID 33096027, PMID 34749885, PMID 34841093, PMID 35116390, PMID 42156227
P01CA021239 (1), U19CA021239 (1)