47 completed, 9 unknown, 8 terminated, 2 withdrawn. 69 Phase 1, 19 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Two-Part Phase 2a Study of RVX000222 in Patients With End-Stage Renal Disease Treated With Hemodialysis apabetalone, Placebos - Kidney Failure, Chronic | Phase 1 / Phase 2 | Not yet recruiting | Resverlogix Corp | 44 | 2024-11-22 | 2023-11-15 |
| Effect of Probiotics in Non-alcoholic Fatty Liver Disease and Steatohepatitis Align Probiotic Supplement Capsule, Placebos - Fatty Liver Disease, Fibrosis, Liver | Phase 1 / Phase 2 | Terminated | Corewell Health East | 14 | 2021-01-12 | 2022-09-27 |
| Evaluation of Tolfenamic Acid in Individuals With PSP at 12-Weeks Tolfenamic Acid, Placebos - Progressive Supranuclear Palsy | Phase 1 / Phase 2 | Unknown | NeuroTau, Inc. | 24 | 2021-01-01 | 2020-02-05 |
| Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism Intralipid, 20% Intravenous Emulsion, Placebos - Obesity | Phase 1 / Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 40 | 2020-12-08 | 2025-03-30 |
| Healthy Body, Healthy Bones After Bariatric Surgery Trial Zoledronic Acid 5 mg/Bag 100 ml Inj, Placebos - Bariatric Surgery Candidate, Bone Loss | Phase 1 / Phase 2 | Completed | University of Nebraska | 10 | 2020-09-01 | 2024-09-24 |
| Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV Pyridostigmine, Placebos, non-invasive vagal nerve stimulation - HIV, Non-HIV | Phase 1 / Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 215 | 2020-08-03 | 2026-08-18 |
| Safety and Tolerability of Lu AG06479 in Healthy Young Men Lu AG06479, Placebos - Healthy | Phase 1 | Terminated | H. Lundbeck A/S | 46 | 2020-07-09 | 2021-12-14 |
| A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE) ICP-022, Placebos - Systemic Lupus Erythematosus | Phase 1 / Phase 2 | Completed | Beijing InnoCare Pharma Tech Co., Ltd. | 60 | 2020-07-09 | 2022-11-30 |
| Study to Evaluate the Safety of CB-280 in Patients With Cystic Fibrosis CB-280, Placebos - Cystic Fibrosis | Phase 1 | Completed | Calithera Biosciences, Inc | 32 | 2020-07-03 | 2022-04-13 |
| Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease Bromocriptine Mesilate, Placebos - Familial Alzheimer Disease (FAD), PSEN1 Mutation | Phase 1 / Phase 2 | Completed | Kyoto University | 8 | 2020-06-05 | 2025-08-29 |
| BXCL501 for Agitation in Schizophrenia Dexmedetomidine Hydrochloride, Placebos - Schizophrenia, Schizoaffective Disorder | Phase 1 | Completed | Yale University | 11 | 2020-03-09 | 2025-07-23 |
| Study of CAD-9303 in Subjects With Schizophrenia CAD-9303, Placebos - Schizophrenia | Phase 1 | Completed | Cadent Therapeutics | 103 | 2020-02-28 | 2021-12-15 |
| Phase I, First-In-Human Study of TT-00920 in Healthy Subjects TT-00920, Placebos - Healthy | Phase 1 | Completed | TransThera Sciences (Nanjing), Inc. | 42 | 2020-02-05 | 2023-02-27 |
| A Clinical Study Trial of Phenlarmide in China Phenlarmide Tablets, Placebos - Parkinson Disease | Phase 1 | Completed | Yiling Pharmaceutical Inc. | 36 | 2019-12-17 | 2021-12-14 |
| Supplementation of Oil Palm Phenolics to Healthy Participants Placebos, Oil Palm Phenolics - Cardiovascular Diseases, Hyperlipidemias | Phase 1 | Unknown | National University of Malaysia | 100 | 2019-12-16 | 2019-12-23 |
| Transcranial Magnetic Stimulation (TMS) in Multiple Sclerosis Transcranial Magnetic Stimulation (TMS), Placebos - Multiple Sclerosis | Phase 1 / Phase 2 | Unknown | Maimónides Biomedical Research Institute of Córdoba | 90 | 2019-10-01 | 2019-08-21 |
| A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Single and Mutiple Ocular Administrations in Healthy Korean and Caucasian Volunteers 5% GLH8NDE, Placebos - Dry Eye Syndromes | Phase 1 | Completed | GL Pharm Tech Corporation | 39 | 2019-09-26 | 2020-12-19 |
| A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3667 GLPG3667 oral suspension, Placebos, GLPG3667 capsules - Healthy | Phase 1 | Completed | Lakefront Biotherapeutics NV | 52 | 2019-09-18 | 2024-09-19 |
| Cannabidiol as a Treatment for AUD Comorbid With PTSD Cannabidiol, Placebos - Alcohol Use Disorder, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Completed | NYU Langone Health | 95 | 2019-09-16 | 2023-06-28 |
| Safety and Tolerability, Pharmacokinetic and Pharmacodynamic Study With IZD334 IZD334, Placebos - Healthy Volunteers, Cryopyrin Associated Periodic Syndrome | Phase 1 | Completed | Inflazome UK Ltd | 64 | 2019-09-13 | 2020-03-02 |
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Pain (4) · Alcoholism (3) · Depressive Disorder, Treatment-Resistant (2) · Inflammation (2) · Lupus Erythematosus, Systemic (2) · Schizophrenia (2) · Acidosis, Lactic (1) · Acne Vulgaris (1) · Acute Pain (1) · Agnosia (1) · Alzheimer Disease (1) · Amyotrophic Lateral Sclerosis (1) · Arthritis, Rheumatoid (1) · Atherosclerosis (1) · Autism Spectrum Disorder (1)
Craig Rush (2) · Xgene Pharmaceutical Group (2) · Yale University (2) · Academic Emergency County Hospital Sibiu (1) · Amgen (1) · Annexon, Inc. (1) · Applied Molecular Transport (1) · Arixa Pharmaceuticals (1) · Beijing InnoCare Pharma Tech Co., Ltd. (1) · Beth Israel Deaconess Medical Center (1) · Bioprojet (1) · Cadent Therapeutics (1) · Calithera Biosciences, Inc (1) · Chemigen, LLC (1) · Children's Hospital Medical Center, Cincinnati (1)
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Antonio Abbate, MD, PhD (1) · Bittoo Kanwar, MD (1) · Charles Marmar, MD (1) · Craig Erickson (1) · Craig R. Rush, PhD (1) · Craig Rush, PhD (1) · D. Andrew Tompkins, MD MHS (1) · Dr. Deven V Parmar, MD,FCP (1) · Elizabeth Ralevski, PhD (1) · Emil T Kuriakose, MD (1) · Feng Xu, PHD (1) · Florin Grosu, MD,PhD (1) · Francesco S Celi, MD, MHSc. (1)
PMID 25606785, PMID 29202623, PMID 29844318, PMID 31268126, PMID 31626696, PMID 32849212, PMID 34193504, PMID 34334250, PMID 34887285, PMID 35295986, PMID 35795564, PMID 37116228, PMID 37221247, PMID 38029807, PMID 38760589, PMID 39719161, PMID 41512716, PMID 41545329, PMID 42214214, PMID 42678337
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