39 completed. 39 Phase 2, 8 Phase 3, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 39 | Completed 39 |
| Phase 3 | 8 | Completed 8 |
| Phase 1 | 6 | Completed 6 |
Follow Pentoxifylline: new trials by email Literature Review of Pentoxifylline trials Research Report on Pentoxifylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Study to Evaluate The Cardioprotective Effect of Pentoxifylline Against Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients Pentoxifylline 400mg plus chemotherapy - Doxorubicin Induced Cardiotoxicity, Breast Cancer | Phase 2 | Completed | Tanta University | 46 | 2025-09-01 | 2026-09-30 |
| Evaluation of Efficacy, Safety and Molecular Mechanism of Pentoxifylline Supplementation in Patients With Hepatic and Obstructive Jaundice Pentoxifylline - Hepatobiliary Disorders | Phase 2 | Completed | Tanta University | 45 | 2025-04-30 | 2026-09-30 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Effect of Pentoxifylline on Preventing Chemotherapy-induced Toxicities in Patients With Breast Cancer Pentoxifylline 400mg plus chemotherapy, Chemotherapy - Breast Cancer Female, Breast Cancer Patients | Phase 2 | Completed | Mansoura University | 100 | 2023-12-25 | 2025-07-28 |
| The Efficacy of Using Pentoxifylline in Patients Undergoing Breast Cancer Surgery Pentoxifylline, paracetamol +ketorolac - Post-Surgical Complication, Breast Cancer Surgery | Phase 2 | Completed | Mansoura University | 92 | 2023-10-30 | 2025-06-26 |
| Role of Pentoxifylline and Celecoxib in Parkinsonism carbidopa-levodopa, Pentoxifylline 400 MG, Celecoxib 200mg - Parkinson Disease | Phase 2 | Completed | Mostafa Bahaa | 80 | 2023-08-07 | 2025-08-12 |
| RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Ibudilast, Pentoxifylline, Placebo - Long COVID, Post COVID Condition | Phase 2 / Phase 3 | Completed | University Health Network, Toronto | 460 | 2023-05-31 | 2026-02-23 |
| Phosphodiesterase Inhibitors, Pentoxifylline, as Adjunctive Therapy in Patients With Ulcerative Colitis. Pentoxifylline 400 MG - Inflammatory Bowel Diseases | Phase 2 | Completed | Tanta University | 60 | 2023-02-02 | 2026-09-17 |
| Pentoxifylline as Adjunctive Therapy in Patients With Ulcerative Colitis Pentoxifylline 400 MG - Inflammatory Bowel Diseases | Phase 2 | Completed | Tanta University | 50 | 2022-10-10 | 2025-08-11 |
| Efficacy of Pentoxifylline and Alpha Lipoic Acid in PCOS Resistant to Clomiphene Citrate Alpha lipoic acid (ALA), Pentoxifylline (PTX), Clomiphene Citrate - Clomiphene Citrate, Resistant Ovary Syndrome | Phase 2 | Completed | Ain Shams University | 120 | 2022-06-05 | 2023-07-20 |
| Pentoxifylline for Treatment of Resistant Major Depression Pentoxifylline, Placebo - Resistant Major Depression | Phase 1 / Phase 2 | Completed | Hawler Medical University | 60 | 2021-12-15 | 2022-09-07 |
| Pentoxifylline as an Adjunct to Citalopram in Adult Patients With Major Depressive Disorder Citalopram (tablet) 20 mg + Pentoxifylline (tablet) 400Mg, Citalopram (tablet) 20 mg + Placebo (tablet) - Major Depressive Disorder | Phase 1 / Phase 2 | Completed | Hawler Medical University | 100 | 2021-11-10 | 2022-09-07 |
| "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" Pentoxifylline, Paclitaxel, Placebo - Breast Cancer Female, Peripheral Neuropathy | Phase 2 / Phase 3 | Completed | Ain Shams University | 66 | 2021-10-03 | 2024-01-23 |
| Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome Pentoxifylline - Acute Coronary Syndrome | Phase 2 / Phase 3 | Completed | Ain Shams University | 43 | 2021-01-01 | 2022-09-07 |
| Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer Atorvastatin, Pentoxifylline, Vitamin E Compound - Male Erectile Disorder, Prostate Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 14 | 2019-11-20 | 2023-10-17 |
| Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers Pentoxifylline, Colchicine - Behçet Disease Affecting Oral Mucosa | Phase 2 | Completed | Ipekyolu Ilac Ltd. Sti | 41 | 2019-03-25 | 2023-08-03 |
| Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia Placebo oral tablet, Pentoxifylline - Schizophrenia | Phase 1 / Phase 2 | Completed | Sadat City University | 80 | 2019-01-01 | 2022-10-25 |
| Does Oral Pentoxifylline Administration Improve Hemoglobin in Hemodialysis Patients? Pentoxifylline - Anemia of Chronic Kidney Disease | Phase 2 | Completed | Tanta University | 57 | 2017-11-01 | 2018-11-08 |
| The Impact of Pentoxifylline and Vitamin E on Radiotherapy-induced Toxicity in Head & Neck Cancer Patients Pentoxifylline, Vitamin E, Cisplatin - Head and Neck Neoplasms | Phase 2 | Completed | Ain Shams University | 60 | 2015-05-02 | 2019-11-26 |
| PPALM-Palm Oil and Pentoxifylline Against Late Morbidity Tocovid SupraBio plus pentoxifylline, Matching placebos - Long-term Adverse Effects of Radiotherapy for Pelvic Cancer | Phase 2 | Completed | Royal Marsden NHS Foundation Trust | 62 | 2014-11-25 | 2019-12-23 |
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Breast Neoplasms (5) · Cardiovascular Diseases (3) · Inflammation (3) · Atherosclerosis (2) · Depressive Disorder, Major (2) · Fatty Liver (2) · Fibrosis (2) · Inflammatory Bowel Diseases (2) · Leishmaniasis, Cutaneous (2) · Muscular Dystrophy, Duchenne (2) · Non-alcoholic Fatty Liver Disease (2) · Acute Coronary Syndrome (1) · Bipolar Disorder (1) · Brain Neoplasms (1) · Breast Neoplasms, Male (1)
Tanta University (5) · Ain Shams University (4) · Indiana University (3) · Cooperative International Neuromuscular Research Group (2) · Hawler Medical University (2) · Mansoura University (2) · Royal Marsden NHS Foundation Trust (2) · Case Western Reserve University (1) · Centro Internacional de Entrenamiento e Investigaciones Médicas (1) · Ipekyolu Ilac Ltd. Sti (1) · M.D. Anderson Cancer Center (1) · Mack Mitchell (1) · Mostafa Bahaa (1) · National Cancer Institute (NCI) (1) · National Heart, Lung, and Blood Institute (NHLBI) (1)
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Diana Escolar, MD (2) · Samir K. Gupta, MD, MS (2) · Talar A Merzamohammad, Pharm. D (2) · Alexandra Taylor (1) · Amin Banihashemi (1) · Angela M Cheung, MD,PhD (1) · Arthur J McCullough, MD (1) · Asmaa Saeed, Bachelor (1) · Atef Taha, M.D (1) · Chad Tang (1) · Claudia O Zein, MD, MSc (1) · Claudia O. Zein, MD, MSc (1) · Craig J McClain, MD (1) · Eman Ibrahim Elberri Lecturer (1)
PMID 15542159, PMID 21677329, PMID 21748765, PMID 23593327, PMID 25393877, PMID 28379954, PMID 28390753, PMID 31472446, PMID 31748905, PMID 31811953, PMID 33008091, PMID 34007848, PMID 35084335, PMID 35093409, PMID 35340032, PMID 35410255, PMID 36341700, PMID 36552855, PMID 37011138, PMID 38817362, PMID 39192162, PMID 39340691, PMID 40253769, PMID 40393653, PMID 40741002, PMID 41164763
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