20 completed, 9 recruiting, 6 not yet recruiting, 2 terminated. 13 Phase 2, 9 Phase 1, 9 Phase 4, 6 Not applicable, 5 Phase 3.
Follow Normal Saline Placebo: new trials by email Literature Review of Normal Saline Placebo trials Research Report on Normal Saline Placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries Paracetamol 2 g, Paracetamol 1 g, Normal Saline Placebo - Shivering, Postoperative Shivering | Phase 4 | Not yet recruiting | Assiut University | 150 | 2026-11-01 | 2026-10-02 |
| Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer OnabotulinumtoxinA (BOTOX®), Normal Saline Placebo - Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 30 | 2026-11-01 | 2026-09-02 |
| Injectable Platelet-Rich Fibrin and Microneedling With or Without Vitamin C for Gingival Phenotype Augmentation. Microneedling, Injectable Platelet-Rich Fibrin (i-PRF), Vitamin C - Thin Gingival Phenotype | Not applicable | Not yet recruiting | University of Science and Technology, Yemen | 27 | 2026-10-01 | 2026-10-06 |
| Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy Cerebrolysin, Normal saline placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Chang Gung Memorial Hospital | 100 | 2026-09-01 | 2026-08-11 |
| Intravenous Dexamethasone Added to Dexmedetomidine After Superior Trunk Block Intravenous Dexamethasone, Normal Saline Placebo, Intravenous Dexmedetomidine - Postoperative Pain, Arthroscopic Shoulder Surgery | Phase 4 | Not yet recruiting | Gaziantep City Hospital | 70 | 2026-09-01 | 2026-08-31 |
| Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial Carbetocin, Oxytocin, Placebo Saline Infusion - Postpartum Hemorrhage, Uterine Atony | Phase 4 | Recruiting | Mansoura University | 332 | 2026-08-08 | 2026-10-09 |
| Administration Of Calcium Gluconate for The Reduction of Blood Loss During Vaginal Delivery calcium gluconate, Normal saline placebo - Postpartum Hemorrhage | Not applicable | Recruiting | Rambam Health Care Campus | 710 | 2026-06-24 | 2026-07-20 |
| Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones. Aminophylline, Normal Saline Placebo - Pediatric Urolithiasis, Distal Ureteral Stone | Phase 2 | Recruiting | Beni-Suef University | 60 | 2026-05-09 | 2026-06-01 |
| Safety and Preliminary Efficacy of hUCMSC-EVs in Interstitial Lung Disease Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles (hUCMSC-EVs), Normal Saline Placebo - Interstitial Lung Disease (ILD) | Phase 1 | Not yet recruiting | Shanghai Zhongshan Hospital | 24 | 2026-04-30 | 2026-05-06 |
| Effect of Dexmedetomidine Combined With FNB/ACB on Sleep Quality After Knee Surgery ropivacaine (local infiltration), Dexmedetomidine, Normal saline placebo - Knee Arthroscopic Surgery | Phase 4 | Recruiting | Affiliated Hospital of Nantong University | 136 | 2026-01-15 | 2026-08-17 |
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| Umbilical Cord Mesenchymal Stem Cells as Adjuvant Therapy in Group E COPD Patients Umbilical Cord Mesenchymal Stem Cells, Normal saline placebo - Chronic Obstructive Pulmonary Disease (COPD) | Phase 2 | Recruiting | RSUP Persahabatan | 20 | 2025-08-08 | 2026-02-27 |
| DMID 23-0015; Lassa Fever CVD 1000 LASSARAB+ aPHAD-SEat 700rU, HDCV Comparator, Normal Saline Placebo - Lassa Fever | Phase 1 | Completed | Wilbur Chen, MD, MS | 54 | 2025-01-13 | 2026-09-24 |
| Early Intravenous Hydrocortisone in Sepsis Early hydrocortisone, Normal saline placebo, Open-label hydrocortisone - Sepsis Severe, Shock, Septic | Not applicable | Terminated | Siriraj Hospital | 116 | 2024-06-25 | 2026-07-28 |
| A Study to Learn About a Combined COVID-19 and Influenza Shot in Healthy Adults BNT162b2 (Omi XBB.1.5)/RIV, BNT162b2 (Omi XBB.1.5), RIV - Influenza, Human, SARS-CoV-2 Infection | Phase 2 | Completed | Pfizer | 644 | 2024-01-31 | 2025-09-30 |
| Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE Ephedrine, Normal Saline Placebo - Labor | Phase 4 | Recruiting | Icahn School of Medicine at Mount Sinai | 100 | 2023-06-26 | 2026-05-06 |
| A Study to Learn About Two or More Vaccines That Are Put Together as One Shot Against Infectious Lung Illnesses, Including COVID-19 and Respiratory Syncytial Virus (RSV). Combination [RSVpreF+BNTb162b2], Bivalent BNT162b2 (original/Omi BA.4/BA.5), RSVpreF - Healthy Participants | Phase 2 | Completed | Pfizer | 1142 | 2023-06-05 | 2024-12-18 |
| Efficacy of QBKPN Site-Specific Immunomodulator in Improving Innate Immune Function & Reducing Respiratory Tract Infection in Older Adults QBKPN SSI, Normal Saline Placebo - Immune Deficiency | Phase 2 | Recruiting | Qu Biologics Inc. | 72 | 2023-04-11 | 2025-01-22 |
| ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial. Tranexamic Acid 500 MG, Terlipressin, Placebo - Hemoptysis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 315 | 2022-03-27 | 2026-04-23 |
| Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms Placebo, Oxycodone, Naloxone - Opioid Use Disorder, Back Pain | Phase 4 | Completed | Vanderbilt University Medical Center | 101 | 2022-03-02 | 2026-09-04 |
Showing 20 of 39. Sign in to see all of them.
COVID-19 (3) · Influenza, Human (3) · Postpartum Hemorrhage (3) · Pain, Postoperative (2) · Sepsis (2) · Shock, Septic (2) · Uterine Inertia (2) · Acute Pain (1) · Anemia, Sickle Cell (1) · Asphyxia Neonatorum (1) · Back Pain (1) · Blood Loss, Surgical (1) · Chronic Pain (1) · Community-Acquired Pneumonia (1) · Critical Illness (1)
Pfizer (2) · Vanderbilt University Medical Center (2) · Affiliated Hospital of Nantong University (1) · American Medical Association Foundation (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Auro Vaccines LLC (1) · Beni-Suef University (1) · Beth Israel Deaconess Medical Center (1) · BioAegis Therapeutics Inc. (1) · Chang Gung Memorial Hospital (1) · Codagenix, Inc (1) · Gaziantep City Hospital (1) · GlaxoSmithKline (1) · Icahn School of Medicine at Mount Sinai (1)
United States (17) · Canada (5) · Australia (2) · China (2) · Egypt (1) · France (1) · Georgia (1) · Indonesia (1) · Israel (1) · Saudi Arabia (1) · Tanzania (1) · Thailand (1) · Yemen (1) · Zimbabwe (1)
Stephen Bruehl, PhD (3) · Benjamin Planquette, MD, PhD (1) · Brian Miles, MD (1) · Chairat Permpikul, MD (1) · Chipo Gwanzura, MD (1) · Daniel Talmor, MD, MPH (1) · David Brousseau, MD, MS (1) · Deepali Kumar, MD (1) · Hany F Badawy, MD (1) · Ian A Chan, MD (1) · James Leader (1) · John Burns, PhD (1)
PMID 24443249, PMID 26232172, PMID 26830642, PMID 28606098, PMID 30640659, PMID 32690640, PMID 34144032, PMID 34807716, PMID 35830641, PMID 37019334, PMID 37106343, PMID 37418263, PMID 37698478, PMID 37742617, PMID 38006967, PMID 38194272, PMID 38360261, PMID 38984984, PMID 39863465, PMID 40006705, PMID 42265408, PMID 42386129
D43TW009343 (1), R01DA037891 (1), R01DA050334 (1)