4 recruiting, 3 completed, 2 not yet recruiting. 9 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Recruiting 4, Completed 3, Not yet recruiting 2 |
Follow Normal Saline Placebo: new trials by email Literature Review of Normal Saline Placebo trials Research Report on Normal Saline Placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries Paracetamol 2 g, Paracetamol 1 g, Normal Saline Placebo - Shivering, Postoperative Shivering | Phase 4 | Not yet recruiting | Assiut University | 150 | 2026-11-01 | 2026-10-02 |
| Intravenous Dexamethasone Added to Dexmedetomidine After Superior Trunk Block Intravenous Dexamethasone, Normal Saline Placebo, Intravenous Dexmedetomidine - Postoperative Pain, Arthroscopic Shoulder Surgery | Phase 4 | Not yet recruiting | Gaziantep City Hospital | 70 | 2026-09-01 | 2026-08-31 |
| Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial Carbetocin, Oxytocin, Placebo Saline Infusion - Postpartum Hemorrhage, Uterine Atony | Phase 4 | Recruiting | Mansoura University | 332 | 2026-08-08 | 2026-10-09 |
| Effect of Dexmedetomidine Combined With FNB/ACB on Sleep Quality After Knee Surgery ropivacaine (local infiltration), Dexmedetomidine, Normal saline placebo - Knee Arthroscopic Surgery | Phase 4 | Recruiting | Affiliated Hospital of Nantong University | 136 | 2026-01-15 | 2026-08-17 |
| Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE Ephedrine, Normal Saline Placebo - Labor | Phase 4 | Recruiting | Icahn School of Medicine at Mount Sinai | 100 | 2023-06-26 | 2026-05-06 |
| Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms Placebo, Oxycodone, Naloxone - Opioid Use Disorder, Back Pain | Phase 4 | Completed | Vanderbilt University Medical Center | 101 | 2022-03-02 | 2026-09-04 |
| Third Dose of Moderna COVID-19 Vaccine in Transplant Recipients mRNA-1273 vaccine, Normal Saline Placebo - Vaccine Response Impaired, Immune Suppression | Phase 4 | Completed | University Health Network, Toronto | 120 | 2021-05-25 | 2022-08-02 |
| Magnesium Infusion for Pain Management in Critically Ill Trauma Patients Magnesium Sulfate in Parenteral Dosage Form, Normal saline placebo - Trauma, Acute Pain | Phase 4 | Recruiting | University of California, Davis | 156 | 2019-12-07 | 2025-11-26 |
| Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study Dexmedetomidine, Normal Saline Placebo - Total Knee Arthroplasty | Phase 4 | Completed | University of Saskatchewan | 40 | 2013-12-01 | 2016-06-20 |
Acute Pain (1) · Back Pain (1) · Blood Loss, Surgical (1) · COVID-19 (1) · Hypothermia (1) · Opioid-Related Disorders (1) · Pain, Postoperative (1) · Patient Satisfaction (1) · Postpartum Hemorrhage (1) · Uterine Inertia (1) · Wounds and Injuries (1)
Affiliated Hospital of Nantong University (1) · Assiut University (1) · Gaziantep City Hospital (1) · Icahn School of Medicine at Mount Sinai (1) · Mansoura University (1) · University Health Network, Toronto (1) · University of California, Davis (1) · University of Saskatchewan (1) · Vanderbilt University Medical Center (1)
United States (3) · Canada (2) · China (1) · Saudi Arabia (1)
Deepali Kumar, MD (1) · Ian A Chan, MD (1) · James Leader (1) · Jurgen Maslany, MD, FRCPC (1) · Kyle Gorman, MD, FRCPC (1) · Mohamed A Tolba, MD (1) · Stephen Bruehl, PhD (1)
R01DA050334 (1)