6 completed, 2 not yet recruiting, 1 terminated. 9 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 6, Not yet recruiting 2, Terminated 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
Follow Normal Saline Placebo: new trials by email Literature Review of Normal Saline Placebo trials Research Report on Normal Saline Placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer OnabotulinumtoxinA (BOTOX®), Normal Saline Placebo - Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | The Methodist Hospital Research Institute | 30 | 2026-11-01 | 2026-09-02 |
| Safety and Preliminary Efficacy of hUCMSC-EVs in Interstitial Lung Disease Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles (hUCMSC-EVs), Normal Saline Placebo - Interstitial Lung Disease (ILD) | Phase 1 | Not yet recruiting | Shanghai Zhongshan Hospital | 24 | 2026-04-30 | 2026-05-06 |
| DMID 23-0015; Lassa Fever CVD 1000 LASSARAB+ aPHAD-SEat 700rU, HDCV Comparator, Normal Saline Placebo - Lassa Fever | Phase 1 | Completed | Wilbur Chen, MD, MS | 54 | 2025-01-13 | 2026-09-24 |
| Safety and Immunogenicity of a Nipah Virus Vaccine HeV-sG-V, Normal Saline Placebo - Nipah Virus Infection | Phase 1 | Completed | Auro Vaccines LLC | 192 | 2020-02-18 | 2022-11-17 |
| Safety Study of Live Attenuated Influenza Vaccine, CodaVax, Delivered Via Intranasal Spray CodaVax-H1N1 influenza vaccine, Normal Saline Placebo - Influenza | Phase 1 | Completed | Codagenix, Inc | 33 | 2019-05-07 | 2020-12-01 |
| Combination Therapy With VRC01 and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions VRC-HIVMAB060-00-AB (VRC01), 10-1074, Normal Saline Placebo - HIV | Phase 1 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 27 | 2019-04-04 | 2021-10-12 |
| A Phase 1b/2a Study of the Safety and Pharmacokinetics of Rhu-plasma Gelsolin in Hospitalized Subjects With CAP Recombinant Human Plasma Gelsolin, Normal Saline Placebo - Community-acquired Pneumonia | Phase 1 / Phase 2 | Completed | BioAegis Therapeutics Inc. | 33 | 2018-08-28 | 2020-01-27 |
| Study to Evaluate Safety, Immunogenicity and Efficacy of PfSPZ Vaccine in HIV Negative and HIV Positive Tanzanian Adults PfSPZ Vaccine, Normal Saline Placebo, PfSPZ Challenge - Malaria, Malaria,Falciparum | Phase 1 | Completed | Sanaria Inc. | 21 | 2018-02-07 | 2019-04-05 |
| Immunomodulatory Properties of Ketamine in Sepsis Ketamine, Normal Saline placebo - Sepsis | Phase 1 / Phase 2 | Completed | Beth Israel Deaconess Medical Center | 19 | 2009-12-01 | 2017-08-21 |
Community-Acquired Pneumonia (1) · Henipavirus Infections (1) · Influenza, Human (1) · Lassa Fever (1) · Lung Diseases, Interstitial (1) · Malaria (1) · Malaria, Falciparum (1) · Prostatic Neoplasms (1) · Sepsis (1) · Shock, Septic (1) · Systemic Inflammatory Response Syndrome (1)
Auro Vaccines LLC (1) · Beth Israel Deaconess Medical Center (1) · BioAegis Therapeutics Inc. (1) · Codagenix, Inc (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Sanaria Inc. (1) · Shanghai Zhongshan Hospital (1) · The Methodist Hospital Research Institute (1) · Wilbur Chen, MD, MS (1)
United States (5) · Australia (2) · China (1) · Georgia (1) · Tanzania (1)
Brian Miles, MD (1) · Daniel Talmor, MD, MPH (1) · Mark J DiNubile, MD (1) · Michael C Sneller, M.D. (1) · Robert W. Frenck Jr., MD (1) · Said Jongo, MD, MMED (1)