4 completed, 1 recruiting. 5 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Normal saline placebo: new trials by email Literature Review of Normal saline placebo trials Research Report on Normal saline placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine Sedation in the ICU (KANINE) RCT ketamine hydrochloride, Normal saline placebo - Mechanical Ventilation, Critically Ill Intensive Care Unit Patients | Phase 3 | Recruiting | McMaster University | 54 | 2025-11-20 | 2026-10-22 |
| ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial. Tranexamic Acid 500 MG, Terlipressin, Placebo - Hemoptysis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 315 | 2022-03-27 | 2026-04-23 |
| The Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Caesarean Section Tranexamic acid injection, Normal saline placebo - Postpartum Hemorrhage | Phase 3 | Completed | University of Zimbabwe | 1226 | 2021-03-23 | 2023-03-20 |
| High-dose Erythropoietin for Asphyxia and Encephalopathy Normal saline placebo, Erythropoietin - Neonatal Encephalopathy, Birth Asphyxia | Phase 3 | Completed | University of California, San Francisco | 500 | 2017-01-01 | 2023-01-30 |
| Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis Intravenous Magnesium Sulfate, Normal Saline Placebo - Sickle Cell Disease | Phase 2 / Phase 3 | Completed | Medical College of Wisconsin | 208 | 2010-12-01 | 2016-01-27 |
Anemia, Sickle Cell (1) · Asphyxia Neonatorum (1) · Critical Illness (1) · Hemoptysis (1) · Postpartum Hemorrhage (1)
Assistance Publique - Hôpitaux de Paris (1) · McMaster University (1) · Medical College of Wisconsin (1) · University of California, San Francisco (1) · University of Zimbabwe (1)
United States (2) · Canada (1) · France (1) · Zimbabwe (1)
Benjamin Planquette, MD, PhD (1) · Chipo Gwanzura, MD (1) · David Brousseau, MD, MS (1) · Sandra Juul, MD PHD (1) · Yvonne Wu, MD MPH (1)
PMID 24443249, PMID 26232172, PMID 28606098, PMID 34144032, PMID 35830641, PMID 37019334, PMID 37106343, PMID 37418263, PMID 37698478, PMID 37742617, PMID 38006967, PMID 38360261, PMID 38984984, PMID 42386129
D43TW009343 (1)