The Effect of Suppression of Adipose Lipolysis on GLP-1 and Energy Intake in Men and Women
| Registry | NCT05417659 |
|---|---|
| Status | Completed |
| Phase | Not applicable |
| Study type | Interventional; randomized, crossover, masking: quadruple, basic science |
| Enrollment | 15 (Actual) |
| Sponsor | University of Bath (Other) |
| Conditions | Energy Intake |
| Interventions | Exercise plus carbohydrate, Exercise plus niacin, Placebo (Dietary supplement, other) |
| Dates | start 2022-10-10, primary completion 2024-03-15, completion 2024-08-30, first posted 2022-06-14, last updated 2025-03-27 |
| Locations | 1 site in United Kingdom |
Related Papers Related Patents Related Grants Related Experts
All trials for Energy Intake All trials of Exercise plus carbohydrate All trials of Exercise plus niacin
Obesity is the outcome of chronic excessive energy intake and reduced energy expenditure leading to energy imbalance. It is a risk factor for many preventable diseases such as metabolic disease and its consequences such as type 2 diabetes and cardiovascular disease. Sedentary adults have been shown to have an increased appetite in excess of energy requirements and adults who are more active are able to better regulate energy intake. It is thought that carbohydrate availability and specifically hepatic glycogen utilisation during exercise is a regulator of appetite. However, the majority of research so far does not support this theory, potentially due to research not examining the tissue-specific link between glycogen use and appetite. The aim of this study is to assess whether altering substrate utilisation during exercise by suppressing lipolysis influences GLP-1 levels and caloric intake post exercise. Additionally, the study will explore if there is a tissue specific link between substrate utilisation and post exercise energy intake and examine potential sex differences.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Control | Placebo comparator | Other: Placebo | A placebo drink to be consumed 1 hour prior to exercise and every 15 minutes during exercise and placebo tablets to be consumed 30 minutes prior to exercise, at the onset of exercise and 30 minutes into exercise. |
| Exercise plus carbohydrate | Active comparator | Dietary Supplement: Exercise plus carbohydrate | A high carbohydrate drink (1.6g/kg) to be consumed 1 hour prior to exercise and further drinks (0.2g/kg) every 15 minutes during exercise. |
| Exercise plus niacin | Experimental | Dietary Supplement: Exercise plus niacin | A dose of niacin (10mg/kg) to be consumed 30 minutes prior to exercise and two further doses (5mg/kg) at the onset of exercise and 30 minutes into exercise. |
Sex: All, ages: 18 Years to 60 Years, accepts healthy volunteers
Inclusion Criteria: * Males aged 18-60 and premenopausal women * Physically active (at least 30 minutes of exercise 3 times a week) * Body mass index 18.0-30.0 kg·m-2 Exclusion Criteria: * Weight instability (>5kg change in body mass over last 6 months) * Restrained eater (e.g. limiting food intake, calorie counting) * Current smoker * Aversion or allergy to test meal foods * Pregnant or lactating * Amenorrhoea in women * Any medical condition or medication that could introduce bias into the study (e.g., diabetes, CVD, lipid or glucose metabolism altering medications) * Any cardiopulmonary condition prohibiting exercise testing * Any contraindication to niacin or aspirin (e.g., diabetes, gout, clotting disorders, allergy to non-steroidal anti-inflammatory drugs)
| Facility | City | Country | Status |
|---|---|---|---|
| Department for Health, University of Bath | Bath | United Kingdom |