8 completed, 4 terminated, 1 enrolling by invitation, 1 withdrawn. 5 Phase 2, 4 Phase 4, 3 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Phase 4 | 4 | Completed 2, Enrolling by invitation 1, Terminated 1 |
| Phase 3 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
| Early Phase 1 | 1 | Terminated 1 |
Follow this drug Literature Review of Nafcillin trials Research Report on Nafcillin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes? Early Dual IV Antibiotic Therapy - MRSA, Early Dual IV Antibiotic Therapy - MSSA, Single Agent IV Antibiotic Therapy - MRSA - Staphylococcus Aureus Bacteremia | Phase 4 | Enrolling by invitation | West Virginia University | 300 | 2025-09-15 | 2026-09-17 |
| DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia Cefazolin, Dalbavancin, Daptomycin - Staphylococcal Bacteraemia | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2021-04-22 | 2024-12-10 |
| Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections Dalbavancin, Vancomycin - Bone Infection, Osteomyelitis | Phase 4 | Completed | Infectious Diseases Physicians, Inc. | 41 | 2018-01-25 | 2023-10-03 |
| Dalbavancin vs Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Dalbavancin, cefazolin, nafcillin, oxacillin or vancomycin - Osteomyelitis | Phase 3 | Withdrawn | Durata Therapeutics International BV (an Affiliate of Actavis, Inc.) | 2016-03-01 | 2016-09-23 | |
| A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Telavancin, Vancomycin, Daptomycin - Bacteremia | Phase 3 | Terminated | Cumberland Pharmaceuticals | 121 | 2014-12-01 | 2020-02-17 |
| Patients Response to Early Switch To Oral:Osteomyelitis Study oral antibiotics, intravenous antibiotics - Osteomyelitis | Early Phase 1 | Terminated | Julio Ramirez | 11 | 2014-03-06 | 2021-04-06 |
| Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006) Daptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent) - Acute Hematogenous Osteomyelitis | Phase 3 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 149 | 2013-09-13 | 2018-08-28 |
| Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection CEM-102, IV or Oral standard of care antibiotics, Rifampin - Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee | Phase 2 | Terminated | Arrevus Inc. | 14 | 2012-12-01 | 2019-04-19 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: - Adenovirus, Anesthesia | Completed | Daniel Benjamin | 3520 | 2011-11-01 | 2023-09-06 | |
| Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection Vancomycin - Bacteremia | Phase 2 | Completed | Duke University | 509 | 2011-02-01 | 2018-01-05 |
| Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment Vancomycin, Daptomycin, Semi-Synthetic Penicillin - Complicated Skin and Skin Structure Infections, S. Aureus Bacteremia | Phase 4 | Terminated | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 92 | 2010-04-19 | 2018-09-05 |
| Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections Daptomycin, Standard of Care (SOC) - Skin Diseases, Infectious | Phase 4 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 396 | 2008-07-23 | 2018-09-05 |
| Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci daptomycin, vancomycin, teicoplanin - Osteomyelitis | Phase 2 | Completed | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 75 | 2007-06-26 | 2018-01-31 |
| Telavancin for Treatment of Uncomplicated Staphylococcus Aureus Bacteremia Telavancin, Vancomycin, nafcillin, oxacillin, or cloxacillin - Gram-Positive Bacterial Infections | Phase 2 | Completed | Cumberland Pharmaceuticals | 60 | 2003-08-01 | 2019-01-16 |
Osteomyelitis (4) · Bacteremia (3) · Staphylococcal Infections (3) · Adenoviridae Infections (1) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1) · Arthritis, Infectious (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Bradycardia (1) · Central Nervous System Infections (1) · Cytomegalovirus Retinitis (1) · Endocarditis (1) · Epilepsy (1) · Gram-Positive Bacterial Infections (1)
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Cumberland Pharmaceuticals (2) · Arrevus Inc. (1) · Daniel Benjamin (1) · Duke University (1) · Durata Therapeutics International BV (an Affiliate of Actavis, Inc.) (1) · Infectious Diseases Physicians, Inc. (1) · Julio Ramirez (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · West Virginia University (1)
United States (12) · Canada (2) · United Kingdom (2) · India (1) · Israel (1) · Panama (1) · Russia (1) · Singapore (1) · Spain (1)
Alena Jamdourek, MD (1) · Alistair Wheeler, MD (1) · Arif R Sawari, MD, MSc, MBA (1) · Chi Hornik, PharmD (1) · David Seligson, MD (1) · Donald Poretz, MD (1) · Ellie Hershberger (1) · Ellie Hershberger, Pharm.D. (1) · G. Ralph Corey, MD (1) · Joy J Juskowich, MD (1) · Julio Ramirez, MD (1) · Vance Fowler, MD (1)
PMID 15276398, PMID 15840453, PMID 19588358, PMID 22530208, PMID 22908174, PMID 24614374, PMID 24884578, PMID 24949994, PMID 26039810, PMID 26926644, PMID 27522443, PMID 27682068, PMID 28137820, PMID 28202770, PMID 28290120, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29677389, PMID 30264119, PMID 30790601, PMID 31317556, PMID 31548185, PMID 31814149, PMID 32324313, PMID 32497307, PMID 32639465, PMID 33029806, PMID 33903114, PMID 34302290, PMID 35370711, PMID 35491971, PMID 35578360, PMID 40802264, PMID 41247430, PMID 41999282, PMID 4902833, PMID 8948280
5UM1AI104681-12 (1)