7 completed, 3 unknown, 1 enrolling by invitation, 1 not yet recruiting. 13 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 7, Unknown 3, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 4 | Completed 2, Not yet recruiting 1, Recruiting 1 |
Follow Methylene Blue: new trials by email Literature Review of Methylene Blue trials Research Report on Methylene Blue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Methylene Blue in the Microhemodynamics of Septic Patients Methylene blue infusion - Septic Shock, Hypoperfusion | Phase 2 / Phase 3 | Recruiting | Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva | 50 | 2026-01-09 | 2026-03-27 |
| Adjunctive Methylene Blue in Septic Shock Methylene Blue, Usual Care - Septic Shock | Phase 3 | Completed | Dr. Shannon M. Fernando | 50 | 2025-06-02 | 2026-03-19 |
| The Effect of Methylene Blue Infiltrating Injection on Anal Pain After Milligan-Morgan Surgery: A Randomized Controlled Clinical Study Methylene Blue - Mixed Hemorrhoids | Phase 3 | Enrolling by invitation | The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine | 60 | 2024-10-25 | 2024-10-28 |
| Methylene Blue for the Treatment of Septic Shock Methylene Blue, Placebo - Septic Shock | Phase 3 | Completed | Northern Jiangsu People's Hospital | 88 | 2024-08-05 | 2026-02-04 |
| Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock Methylene Blue, Placebo - Neonatal Sepsis, Shock, Septic | Phase 2 / Phase 3 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 130 | 2024-03-15 | 2024-03-12 |
| Low Dose Versus High Dose Methylene Blue in Septic Patients Normal saline, Methylene Blue low dose, Methylene Blue high dose - Septic Shock | Phase 2 / Phase 3 | Completed | National Cancer Institute, Egypt | 90 | 2023-08-01 | 2024-07-05 |
| Methylene Blue and Microcirculation in Septic Shock Methylene Blue, Norepinephrine infusion - Septic Shock | Phase 3 | Unknown | Cairo University | 32 | 2020-03-10 | 2020-03-05 |
| Methylene Blue in Early Septic Shock 0.9% sodium chloride, Methylene Blue - Septic Shock | Phase 2 / Phase 3 | Completed | Hospital Civil de Guadalajara | 91 | 2017-03-17 | 2022-11-04 |
| Tzanck Smear With Methylene Blue Stain for Herpes Methylene blue, Giemsa stain - Herpes Simplex, Herpes Zoster | Phase 3 | Unknown | Chulalongkorn University | 150 | 2017-03-07 | 2017-08-04 |
| What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin Methylene Blue, Terlipressin - Septic Shock, Refractory Shock | Phase 3 | Unknown | Ramathibodi Hospital | 60 | 2016-12-01 | 2018-08-29 |
| Efficacy Study of Methenamine + Methylthioninium Chloride vs Phenazopyridine for the Symptomatic Control of Dysuria Methenamine and Methylthioninium chloride, Phenazopyridine - Dysuria | Phase 3 | Completed | EMS | 316 | 2016-06-27 | 2020-07-07 |
| Use of Indocyanine Green Cholangiography and Methylene Blue to Detect Postoperative Biliary Fistula After Hepatectomy indocyanine green fluorescent cholangiography, methylene blue - Liver Disease | Phase 3 | Completed | Centre Hospitalier Universitaire, Amiens | 150 | 2013-07-08 | 2025-07-23 |
| Methylene Blue for Cognitive Dysfunction in Bipolar Disorder Methylene Blue - Bipolar Disorder | Phase 3 | Completed | Nova Scotia Health Authority | 40 | 2003-11-01 | 2008-04-01 |
Shock, Septic (8) · Biliary Fistula (1) · Bipolar Disorder (1) · Dysuria (1) · Herpes Simplex (1) · Herpes Zoster (1) · Liver Diseases (1) · Neonatal Sepsis (1) · Shock (1)
Cairo University (1) · Centre Hospitalier Universitaire, Amiens (1) · Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva (1) · Chulalongkorn University (1) · Dr. Shannon M. Fernando (1) · EMS (1) · Hospital Civil de Guadalajara (1) · National Cancer Institute, Egypt (1) · Northern Jiangsu People's Hospital (1) · Nova Scotia Health Authority (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Ramathibodi Hospital (1) · The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine (1)
Brazil (2) · Canada (2) · China (2) · Egypt (2) · Thailand (2) · France (1) · India (1) · Mexico (1)
Ahmed Mukhtar, Professor (1) · Ehab H Shaker, MD (1) · Martin Alda, MD FRCPC (1) · Miguel Ibarra-Estrada, MD (1) · Pawinee Rerknimitr, MD, MSc (1) · Qingquan Lyu, Master (1) · Shannon M Fernando, MD (1) · Sourabh Dutta, MD, PhD (1)
PMID 36915146, PMID 11588440, PMID 12500513, PMID 12519925, PMID 14759425, PMID 16134766, PMID 17698886, PMID 18477932, PMID 21246318, PMID 26683506, PMID 27284082, PMID 27673307, PMID 28723883, PMID 29151412, PMID 29508706, PMID 29936590, PMID 30231909, PMID 32270211, PMID 32453920, PMID 32520577, PMID 34719443, PMID 36237547, PMID 36505110, PMID 36705345, PMID 39780053, PMID 8648456, PMID 9250657