5 completed, 2 recruiting, 2 unknown, 1 terminated. 10 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 5, Recruiting 2, Unknown 2, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Methylene Blue: new trials by email Literature Review of Methylene Blue trials Research Report on Methylene Blue
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methylene Blue in Total Knee Arthroplasty (TKA) Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty - Total Knee Arthroplasty, Prosthetic-joint Infection | Phase 1 | Recruiting | University of Miami | 20 | 2026-02-04 | 2026-04-14 |
| Adjunctive Methylene Blue for Immunotherapy-related CRS and ICANS: Phase I Study Methylene Blue - Cytokine Release Syndrome, ICANS | Phase 1 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 18 | 2025-06-28 | 2025-09-11 |
| COVID-19 Treatment Using Methylene Blue and Photodynamic Therapy Methylene Blue and Photodynamic Therapy - SARS-CoV-2 | Phase 1 | Completed | I.M. Sechenov First Moscow State Medical University | 60 | 2020-04-24 | 2021-06-22 |
| Clinical Application of Methylene Blue for Treatment of Covid-19 Patients MCN (Methylene blue, vitamin C, N-acetyl cysteine) - Covid-19 | Phase 1 | Unknown | Mashhad University of Medical Sciences | 20 | 2020-04-19 | 2020-05-04 |
| Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice Saline, Methylene Blue - Jaundice | Phase 1 | Unknown | Jiaolin Ning,MD | 64 | 2019-04-01 | 2019-10-01 |
| Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery MB and fluorescent imaging - Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism | Phase 1 / Phase 2 | Completed | Sheffield Teaching Hospitals NHS Foundation Trust | 41 | 2014-10-01 | 2016-11-02 |
| Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities Methylene Blue, 20% I.V. Fat Emulsion, Insertion of optical fiber - Abscess | Phase 1 | Completed | University of Rochester | 21 | 2014-09-01 | 2026-04-07 |
| Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency Regimens (Primaquine, Methylene blue) - G6PD Normal, G6PD Deficient | Phase 1 | Completed | University of Oxford | 20 | 2013-07-01 | 2015-11-03 |
| Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Methylene Blue - Methemoglobinemia, Congenital Methemoglobinemia | Phase 1 | Completed | American Regent, Inc. | 12 | 2012-10-01 | 2025-06-05 |
| Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome Methylene blue, Nitric oxide, Methylene blue & nitric oxide - Sepsis | Phase 1 | Terminated | Northern State Medical University | 28 | 2004-04-01 | 2015-10-06 |
COVID-19 (2) · Abscess (1) · Acute Lung Injury (1) · Congenital Methemoglobinemia (1) · Coronavirus Infections (1) · Cytokine Release Syndrome (1) · Jaundice (1) · Methemoglobinemia (1) · Sepsis (1)
American Regent, Inc. (1) · I.M. Sechenov First Moscow State Medical University (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Jiaolin Ning,MD (1) · Mashhad University of Medical Sciences (1) · Northern State Medical University (1) · Sheffield Teaching Hospitals NHS Foundation Trust (1) · University of Miami (1) · University of Oxford (1) · University of Rochester (1)
China (2) · Russia (2) · United States (2) · Iran (1) · Thailand (1) · United Kingdom (1)
Artem A. Shiryaev, Ph.D. (1) · Ashwani K Sharma, MD (1) · Colin A McNamara, MD, MBA (1) · Daryoush Hamidi Alamdari, Ph.D (1) · Fareeda Hosein, MD (1) · Igor V. Reshetov, Prof. (1) · Jianxiang Wang (1) · Jiaolin Ning, MD (1) · Laurie Christensen, BS (1) · Mikhail Y Kirov, MD, PhD (1) · Saba Balasubramanian, MS FRCS PhD (1) · Timothy M Baran, PhD (1) · Victor B. Loschenov, Prof. (1)
PMID 32828741, PMID 34019535, PMID 37464107, PMID 37961683, PMID 38316055, PMID 38414658, PMID 38501946