20 completed, 2 unknown, 2 withdrawn, 1 recruiting. 12 Phase 3, 6 Phase 2, 5 Not applicable, 2 Phase 1, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 11, Withdrawn 1 |
| Phase 2 | 6 | Completed 4, Terminated 1, Unknown 1 |
| Not applicable | 5 | Completed 4, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
Follow Medroxyprogesterone: new trials by email Literature Review of Medroxyprogesterone trials Research Report on Medroxyprogesterone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF) Doxycycline combined with Medroxyprogesterone, Doxycycline combined with placebo - Chronic Endometritis | Not applicable | Recruiting | Fang Wang | 1000 | 2024-04-09 | 2026-03-23 |
| Observation vs Progesterone Treatment for Management of Uterine Arteriovenous Malformation MedroxyPROGESTERone Injection [Depo-Provera], Other - Arteriovenous Malformations | Phase 4 | Unknown | HaEmek Medical Center, Israel | 28 | 2022-08-01 | 2022-08-08 |
| Repurposed Drugs to Improve Haematological Responses in Myelodysplastic Syndromes Sodium Valproate, Bezafibrate, Medroxyprogesterone, Danazol - Myelodysplastic Syndromes (MDS) | Phase 2 | Unknown | Prof. Janet Dunn | 120 | 2021-12-21 | 2023-10-03 |
| A Study Comparing Subcutaneous Injection of Sayana Press In the Upper Arm Versus Anterior Thigh and Abdomen Sayana Press - Healthy | Phase 1 | Completed | Pfizer | 67 | 2021-09-16 | 2025-08-14 |
| Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response Progesterone, GnRH Antagonist - IVF, GnRH Antagonist | Phase 3 | Completed | ShangHai Ji Ai Genetics & IVF Institute | 784 | 2020-06-04 | 2023-08-30 |
| Hormone Replacement for Premature Ovarian Insufficiency Hormone Replacement Therapy, Combined Oral Contraceptives - Primary Ovarian Insufficiency | Phase 3 | Withdrawn | University of Pennsylvania | 2016-03-01 | 2019-07-05 | |
| Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women Leuprolide acetate, Estradiol, Medroxyprogesterone - Cognitive Impairment, Executive Dysfunction | Not applicable | Completed | University of Colorado, Denver | 17 | 2014-09-08 | 2022-01-10 |
| Role of Pregnancy Related Hormones in Lowering the Insulin Requirement in Pregnant Women With Type 1 Diabetes Estradiol, medroxyprogesterone, hydrocortisone, GH, Matching placebo - Type 1 Diabetes | Phase 1 | Withdrawn | Sansum Diabetes Research Institute | 2012-07-01 | 2018-04-18 | |
| Health Benefits of Vitamin D and Calcium in Women With PCOS (Polycystic Ovarian Syndrome) Vitamin D2 (Ergocalciferol), Medroxyprogesterone (Provera), Vitamin D3 (Cholecalciferol) - Polycystic Ovarian Syndrome, Vitamin D Deficiency | Not applicable | Completed | Yale University | 36 | 2008-08-01 | 2021-08-13 |
| Safety of the Etonogestrel-releasing Implant During the Puerperium of Healthy Women etonogestrel implant, depot medroxyprogesterone acetate - Breastfeeding, Contraception | Not applicable | Completed | University of Sao Paulo | 40 | 2007-07-01 | 2017-05-15 |
| Medroxyprogesterone +/- Cyclophosphamide & Methotrexate in Hormone Receptor-Negative Recurrent/Metastatic Breast Cancer Medroxyprogesterone progesterone acetate (MPA), Medroxyprogesterone with Cyclophosphamide + Methotrexate - Estrogen Receptor-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer | Phase 2 | Completed | Indiana University | 30 | 2007-07-01 | 2023-10-16 |
| A Study Comparing Mirena and Systemic Progestin for Endometrial Hyperplasia Provera (medroxyprogesterone/progestin), Provera (medroxyprogesterone), Mirena (levonorgestrel) - Endometrial Hyperplasia | Phase 4 | Completed | University Hospital of North Norway | 170 | 2005-05-01 | 2019-04-05 |
| Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus Laboratory Biomarker Analysis, Medroxyprogesterone, Therapeutic Conventional Surgery - Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma | Phase 2 | Completed | Gynecologic Oncology Group | 75 | 2004-04-01 | 2016-04-11 |
| Medroxyprogesterone Compared With Venlafaxine in Treating Hot Flashes in Women medroxyprogesterone, venlafaxine - Hot Flashes | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 227 | 2002-04-01 | 2016-07-13 |
| Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer medroxyprogesterone, ethinyl estradiol, norgestrel - Endometrial Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 52 | 2002-02-01 | 2013-05-03 |
| Alzheimer's Disease: Therapeutic Potential of Estrogen Transdermal estradiol, Medroxyprogesterone, Placebo Patch - Alzheimer Disease | Phase 2 / Phase 3 | Completed | University of Wisconsin, Madison | 42 | 2001-09-01 | 2018-08-23 |
| Hormone Replacement Therapy for Hot Flashes and/or Vaginal Symptoms in Postmenopausal Women Receiving Tamoxifen for Breast Cancer conjugated estrogens, medroxyprogesterone - Breast Cancer, Hot Flashes | Phase 3 | Completed | Eastern Cooperative Oncology Group | 2000-11-28 | 2023-06-15 | |
| Randomized Study of Oral Contraceptives or Hormone Replacement Therapy in Women With Systemic Lupus Erythematosus estradiol, ethinyl estradiol, medroxyprogesterone - Systemic Lupus Erythematosus | Not applicable | Completed | National Center for Research Resources (NCRR) | 970 | 2000-06-01 | 2005-06-24 |
| Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer medroxyprogesterone - Endometrial Cancer | Phase 2 | Terminated | Gynecologic Oncology Group | 360 | 1998-11-01 | 2013-06-10 |
| S9630, Medroxyprogesterone in Treating Women With Breast Cancer medroxyprogesterone, tamoxifen citrate, adjuvant therapy - Breast Cancer, Endometrial Cancer | Phase 3 | Completed | SWOG Cancer Research Network | 313 | 1997-03-01 | 2012-10-31 |
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Cardiovascular Diseases (4) · Coronary Disease (4) · Breast Neoplasms (3) · Endometrial Neoplasms (3) · Heart Diseases (3) · Myocardial Ischemia (3) · Breast Carcinoma In Situ (2) · Hot Flashes (2) · Osteoporosis (2) · Rare Diseases (2) · Alzheimer Disease (1) · Arteriovenous Malformations (1) · Arthritis (1) · Bone Diseases (1) · Breast Feeding (1)
National Heart, Lung, and Blood Institute (NHLBI) (3) · Gynecologic Oncology Group (2) · Alliance for Clinical Trials in Oncology (1) · Centre Leon Berard (1) · Eastern Cooperative Oncology Group (1) · Fang Wang (1) · HaEmek Medical Center, Israel (1) · Indiana University (1) · National Cancer Institute (NCI) (1) · National Center for Research Resources (NCRR) (1) · National Institute of Dental and Craniofacial Research (NIDCR) (1) · Pfizer (1) · Prof. Janet Dunn (1) · SWOG Cancer Research Network (1) · Sansum Diabetes Research Institute (1)
United States (14) · China (2) · Norway (2) · Belgium (1) · Brazil (1) · United Kingdom (1)
Barbara L. Smith, MD, PhD (1) · Carolina S Vieira, MD, PhD (1) · Charles F. Hildebolt (1) · Charles L. Loprinzi, MD (1) · Fang Wang (1) · Francisco A. R. Garcia, MD, MPH (1) · George L. Mutter, MD (1) · Graciela S. Alarcon (1) · Howard Hodis (1) · John P. Curtin, MD (1) · Karen Lu (1) · Kathy Miller, MD (1) · Kerry L Hildreth, MD (1) · Lois Jovanovic, MD (1)
PMID 16400639, PMID 16505409, PMID 17329508, PMID 17932908, PMID 19913145, PMID 22155796, PMID 22542366, PMID 22780885, PMID 22981957, PMID 24286192, PMID 32909630, PMID 38272383
R01AG017196 (1), U01HL040232 (1), U01HL050840 (1), U10CA027469 (1), U10CA032102 (1), U10CA037429 (1), UL1TR001082 (1)