11 completed, 1 active not recruiting, 1 enrolling by invitation, 1 terminated. 8 Phase 2, 5 Not applicable, 4 Phase 1, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 7, Active not recruiting 1 |
| Not applicable | 5 | Completed 3, Enrolling by invitation 1, Terminated 1 |
| Phase 1 | 4 | Completed 4 |
| Early Phase 1 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Liothyronine: new trials by email Literature Review of Liothyronine trials Research Report on Liothyronine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Irinotecan, Temozolomide, Bevacizumab - Recurrent Medulloblastoma, Recurrent Ependymoma | Phase 2 | Active not recruiting | Pediatric Brain Tumor Consortium | 62 | 2022-04-04 | 2026-07-28 |
| Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma Liothyronine, Lomustine, Methimazole - Recurrent Glioblastoma, Recurrent Gliosarcoma | Early Phase 1 | Withdrawn | Emory University | 2021-10-20 | 2022-12-02 | |
| Energy Metabolism in Thyroidectomized Patients Levothyroxine, Liothyronine, Placebo - Thyroid Goiter, Hypothyroidism | Phase 2 | Completed | Virginia Commonwealth University | 13 | 2020-10-28 | 2024-06-14 |
| Developing Oral LT3 Therapy for Heart Failure - HFpEF liothyronine, Placebo - Heart Failure With Preserved Ejection Fraction, Low Triiodothyronine Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-03-08 | 2025-01-08 |
| Developing Oral LT3 Therapy for Heart Failure - HFrEF Liothyronine, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-02-11 | 2024-12-24 |
| Identification of Non-responders to Levothyroxine Therapy Levothyroxin, Liothyronine - Hypothyroidism, Biomarkers | Phase 2 | Completed | Oslo University Hospital | 69 | 2018-08-14 | 2021-03-17 |
| Effects of Liothyronine on Energy Expenditure and Cardiovascular Function Liothyronine, Levothyroxine, Placebos - Healthy | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 22 | 2017-10-20 | 2021-03-26 |
| Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients Liothyronine, Levothyroxin, Placebos - Hypothyroidism | Phase 2 / Phase 3 | Completed | Azienda USL Modena | 160 | 2017-03-14 | 2023-04-21 |
| Open-label Study of Liothyronine in MS liothyronine - Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive | Phase 1 | Completed | Johns Hopkins University | 20 | 2015-07-01 | 2018-02-12 |
| Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations Liothyronine - Insulin Resistance, Diabetes Mellitus | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 7 | 2015-04-17 | 2019-12-05 |
| Mechanistic Study of Subclinical Hypothyroidism In the Elderly Levothyroxine, Liothyronine, Thyrotropin-Releasing Hormone - Subclinical Hypothyroidism | Not applicable | Completed | University of Pennsylvania | 14 | 2015-01-01 | 2021-03-09 |
| Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Liothyronine - Heart Failure, Low T3 Syndrome | Not applicable | Completed | Jens Faber | 21 | 2011-07-01 | 2019-07-16 |
| Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors Levothyroxine, Liothyronine - Hypothyroidism, Brain Tumor | Not applicable | Terminated | M.D. Anderson Cancer Center | 12 | 2006-02-01 | 2013-06-24 |
| Evaluation Study of L-T3 Utility in the Follow-up of Patients With Thyroid Cancer Liothyronine - Thyroid Cancer | Not applicable | Completed | Patrice Perron | 70 | 2003-09-01 | 2014-04-09 |
Hypothyroidism (6) · Euthyroid Sick Syndromes (3) · Heart Failure (3) · Thyroid Diseases (2) · Thyroid Neoplasms (2) · Brain Neoplasms (1) · Diabetes Mellitus (1) · Endocrine System Diseases (1) · Ependymoma (1) · Glioblastoma (1) · Gliosarcoma (1) · Goiter (1) · Insulin Resistance (1) · Medulloblastoma (1) · Multiple Sclerosis, Chronic Progressive (1)
University of Pennsylvania (3) · Virginia Commonwealth University (2) · Azienda USL Modena (1) · Emory University (1) · Enhanced Emirates Limited (1) · Jens Faber (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Oslo University Hospital (1) · Patrice Perron (1) · Pediatric Brain Tumor Consortium (1)
United States (9) · Canada (1) · Denmark (1) · Italy (1) · Norway (1) · United Arab Emirates (1)
Anne R Cappola, MD,ScM (2) · Angeliki M Stamatouli, MD (1) · Anne R Cappola, MD, ScM (1) · Erik Fink Eriksen, Professor (1) · Francesco S Celi, MD, MHSc. (1) · Jean Verreault, MD (1) · Jeffrey J. Olson, MD (1) · Jens Faber, MDSci (1) · Marie-France Langlois, MD (1) · Matthias Karajannis, MD, MS (1) · Patrice Perron, MD (1) · Rebecca J Brown, M.D. (1) · Scott Newsome, DO (1)
PMID 31588494, PMID 32191645, PMID 34867829, PMID 35273566, PMID 35295986, PMID 35572853
R61HL146390 (2), 2017 (1), K24AG042765 (1), P30CA138292 (1), R21DK122310 (1), UM1CA081457 (1)