32 completed, 3 recruiting, 3 terminated, 2 unknown. 10 Not applicable, 9 Phase 4, 7 Phase 2, 5 Early Phase 1, 5 Phase 3.
Follow Lexiscan: new trials by email Literature Review of Lexiscan trials Research Report on Lexiscan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET [13N]NH3, Lexiscan, Positron emission tomography - Sickle Cell Disease | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 40 | 2023-10-10 | 2026-05-06 |
| The MATCH Investigation: CT Myocardial Perfusion and CT-FFR vs PET MPI PET-MPI Protocol, CT-MPI, Coronary CT angiography (CCTA) for CT-FFR calculation - Coronary Artery Disease | Not applicable | Completed | Emory University | 20 | 2021-06-16 | 2026-01-06 |
| Regadenoson Infusion of Marginalized Donor Lungs in an EVLP System Regadenoson, Placebo - Lung Transplant | Early Phase 1 | Completed | University of Maryland, Baltimore | 47 | 2020-06-22 | 2024-08-05 |
| Allograft Dysfunction in Heart Transplant Regadenoson - Heart Transplant Failure and Rejection | Phase 4 | Recruiting | Paul Kim | 376 | 2019-10-01 | 2026-05-01 |
| Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome Regadenoson myocardial perfusion imaging stress test, Arm exercise electrocardiographic stress test, Treadmill electrocardiographic stress test - Veterans Referred to the St. Louis VAMC Stress Tes | Terminated | VA Office of Research and Development | 133 | 2018-07-01 | 2022-02-17 | |
| Quantitative 13N-Ammonia Cardiac Rest/Stress Digital PET/CT Cardiac Perfusion Rest/Stress Digital PET/CT, N-13 ammonia, Regadenoson - Coronary Artery Disease | Completed | Stanford University | 15 | 2017-03-29 | 2021-10-26 | |
| New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF) Adenosine, Regadenoson, O-15 labeled radioactive water - MRI Scans | Early Phase 1 | Recruiting | University of Utah | 100 | 2017-03-03 | 2026-07-07 |
| Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System Lexiscan - Cardiovascular Diseases, Coronary Artery Disease | Phase 2 | Completed | Medical University of South Carolina | 24 | 2016-02-09 | 2019-08-09 |
| Stress Cardiac MRI for Evaluation of Nonspecific Allograft Dysfunction Regadenoson, Gadolinium, Cardiac MRI - Heart Transplant, Acute Graft Rejection | Phase 4 | Completed | Paul Kim | 14 | 2015-11-01 | 2017-08-22 |
| Brain Interstitium Temozolomide Concentration Pre and Post Regadenoson Administration Regadenoson, Temozolomide, Microdialysis catheter - Blood Brain Barrier Defect | Early Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2015-02-01 | 2018-11-20 |
| Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging Regadenoson - Coronary Artery Disease | Phase 4 | Completed | Timothy M. Bateman | 40 | 2014-09-03 | 2018-09-19 |
| Regadenoson for Acute Vasoreactivity Testing in Pulmonary Hypertension Regadenoson - Pulmonary Hypertension | Not applicable | Terminated | National Jewish Health | 10 | 2014-08-01 | 2021-01-19 |
| Stress CT Perfusion in Patients With Chest Pain Regadenoson - Coronary Artery Disease | Not applicable | Completed | University of Chicago | 150 | 2014-06-01 | 2021-02-21 |
| Phase Analysis and Obstructive CAD on Rubidium PET Regadenoson - Coronary Artery Disease | Phase 2 | Withdrawn | Emory University | 2013-10-01 | 2014-06-02 | |
| Characterization of Myocardial Blood Flow Measurements Using Lexiscan®™ (Regadenoson) (Lexiscan®™) Rubidium-82 Myocardial Perfusion PET: A Temporal-Dependency Investigation Regadenoson, Rubidium-82 - Myocardial Blood Flow Reserve | Phase 4 | Completed | Timothy M. Bateman, MD | 80 | 2013-07-01 | 2018-08-16 |
| A Phase II Trial of Regadenoson in Sickle Cell Anemia Regadenoson, Placebo - Sickle Cell Anemia | Phase 2 | Completed | Dana-Farber Cancer Institute | 100 | 2013-07-01 | 2018-02-07 |
| Repeat Dose Tolerance Study of Regadenoson in Healthy Subjects Regadenoson, Placebo - Healthy Volunteers | Phase 1 | Completed | Astellas Pharma Global Development, Inc. | 36 | 2013-05-01 | 2013-08-30 |
| Heart Rate Response to Regadenoson and Sudden Cardiac Death regadenoson - Left Ventricular Systolic Dysfunction, Sudden Cardiac Death | Not applicable | Completed | University of Alabama at Birmingham | 90 | 2013-02-01 | 2022-10-18 |
| Regadenoson Stress-MRI to Identify Coronary Artery Disease in Atrial Fibrillation Patients Regadenoson MRI, Gadobenate dimeglumine - Atrial Fibrillation, Coronary Artery Disease | Phase 2 | Completed | University of Utah | 30 | 2013-01-01 | 2017-12-13 |
| Development of a PET-MR Myocardial Perfusion Examination Using Regadenoson Regadenoson - Ischemic Heart Disease | Phase 4 | Completed | Washington University School of Medicine | 16 | 2013-01-01 | 2018-06-15 |
Showing 20 of 43. Sign in to see all of them.
Coronary Artery Disease (22) · Myocardial Ischemia (7) · Anemia, Sickle Cell (4) · Coronary Disease (3) · Asthma (2) · Cardiovascular Diseases (2) · Ischemia (2) · Pulmonary Disease, Chronic Obstructive (2) · Angina Pectoris (1) · Atherosclerosis (1) · Atrial Fibrillation (1) · Death, Sudden, Cardiac (1) · Diabetes Mellitus, Type 2 (1) · Genetic Diseases, Inborn (1) · Hypertension, Pulmonary (1)
Astellas Pharma Inc (4) · University of Utah (4) · University of Chicago (3) · Astellas Pharma Global Development, Inc. (2) · Dana-Farber Cancer Institute (2) · Emory University (2) · Gilead Sciences (2) · Mayo Clinic (2) · Paul Kim (2) · Washington University School of Medicine (2) · Dipan Shah (1) · Hartford Hospital (1) · Medical University of South Carolina (1) · National Jewish Health (1) · Northwestern University (1)
United States (43) · Argentina (1) · Peru (1) · Puerto Rico (1)
David Nathan, MD (2) · Edward DiBella, Ph.D. (2) · Timothy M Bateman, MD (2) · Amit Patel, M.D. (1) · Ananda Basu, MBBS, M.D. (1) · Brent Wilson, MD (1) · Brett E Fenster, MD (1) · Carlo De Cecco, MD, PhD (1) · Christine Lau, MD (1) · Dipan Shah, M.D. (1) · Fabio Esteves, MD (1) · Fadi G Hage, MD (1)
PMID 11693758, PMID 11943259, PMID 16353442, PMID 16890123, PMID 17194875, PMID 17826318, PMID 18551063, PMID 19284612, PMID 20413602, PMID 20643330, PMID 21082298, PMID 21555100, PMID 21962016, PMID 21968545, PMID 22484721, PMID 23180239, PMID 23272658, PMID 23377438, PMID 24314823, PMID 24355800, PMID 24457279, PMID 26242981, PMID 26607361, PMID 28174191, PMID 28224449, PMID 28528431, PMID 29296811, PMID 3308166, PMID 34335296, PMID 9498540
1RC2HL101367-01 (1), P50HL110790 (1), R01HL128492 (1), R01HL135328 (1)