11 completed, 10 recruiting, 4 unknown, 2 not yet recruiting. 22 Not applicable, 3 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Completed 10, Recruiting 8, Unknown 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Not yet recruiting 2, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow Intermittent Theta Burst Stimulation (iTBS): new trials by email Literature Review of Intermittent Theta Burst Stimulation (iTBS) trials Research Report on Intermittent Theta Burst Stimulation (iTBS)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ONE-P TMS Military Veterans D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-20 |
| ONE-P TMS First Responders D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-19 |
| Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making continuous Theta Burst Stimulation (cTBS), intermittent Theta Burst Stimulation (iTBS), sham Theta Burst Stimulation (sham TBS) - Normal Physiology | Early Phase 1 | Recruiting | National Institute on Drug Abuse (NIDA) | 600 | 2026-10-27 | 2026-10-22 |
| Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in Stroke Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS), Sham Continuous Theta Burst Stimulation - Ischemic Stroke | Not applicable | Recruiting | Ankara Etlik City Hospital | 60 | 2026-09-30 | 2026-09-22 |
| Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression Intermittent Theta Burst Stimulation (iTBS) - Treatment-resistant Depression (TRD), Major Depression | Not applicable | Recruiting | Gulhane Training and Research Hospital | 100 | 2026-09-01 | 2026-09-14 |
| Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture continuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS), Sham - Psychopathy | Not applicable | Recruiting | University of Colorado, Denver | 60 | 2026-07-13 | 2026-10-08 |
| CARED : A Novel Rapid Treatment Paradigm for Depression Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy - Major Depressive Disorder | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 30 | 2026-04-14 | 2026-06-25 |
| Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia intermittent theta burst stimulation (iTBS), Methylphenidate (MPH) - Alzheimer s Disease, Alzheimer Dementia (AD) | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 12 | 2026-01-01 | 2025-12-12 |
| Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD intermittent theta burst stimulation (iTBS) - ADHD | Not applicable | Recruiting | Bradley Hospital | 50 | 2025-09-01 | 2025-10-22 |
| Cross-validating the iTBS-induced Hemodynamic Response From fNIRS and fMRI: a Concurrent iTBS-fMRI-fNIRS Study Intermittent theta burst stimulation (iTBS) - Healthy Adults | Completed | The Hong Kong Polytechnic University | 13 | 2025-04-22 | 2026-09-16 | |
| Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH intermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS), Sham TMS - Methamphetamine Use Disorders, HIV | Not applicable | Completed | Gopalkumar Rakesh | 12 | 2025-03-11 | 2026-08-06 |
| A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients Intermittent theta burst stimulation (iTBS), Functional electrical stimulation (FES), Transcutaneous spinal cord stimulation (TSCS) - SCI - Spinal Cord Injury | Not applicable | Recruiting | University of Miami | 25 | 2024-11-04 | 2026-04-23 |
| Optimization of Time Parameters of Priming iTBS for Poststroke Motor Rehabilitation continuous theta burst stimulation (cTBS), intermittent theta burst stimulation (iTBS), Robot-assisted training - Stroke, Stroke Rehabilitation | Not applicable | Completed | The Hong Kong Polytechnic University | 62 | 2024-10-01 | 2026-01-06 |
| TMS as a Treatment for Apathy in Alzheimer's Disease Intermittent Theta Burst Stimulation (iTBS) - Alzheimer Disease, Apathy in Dementia | Not applicable | Terminated | Massachusetts General Hospital | 3 | 2024-05-02 | 2025-05-15 |
| Targeting Specific Brain Networks to Treat Specific Symptoms in Depression Intermittent Theta Burst Stimulation (iTBS) - Major Depressive Disorder | Not applicable | Recruiting | Massachusetts General Hospital | 80 | 2024-03-12 | 2026-10-09 |
| Exploring the Cortical Hemodynamic Variability of Prefrontal iTBS: a Concurrent TBS/fNIRS Study Intermittent theta burst stimulation (iTBS) - Healthy | Not applicable | Completed | The Hong Kong Polytechnic University | 40 | 2023-10-18 | 2026-09-17 |
| Accelerated Theta Burst in Chronic Pain: A Biomarker Study Intermittent Theta Burst Stimulation (iTBS) - Chronic Pain | Not applicable | Withdrawn | Stanford University | 2023-06-01 | 2024-12-20 | |
| fMRI-guided Transcranial Magnetic Stimulation Treatment for Parkinson's Disease Intermittent theta burst stimulation (iTBS) - Parkinson's Disease | Not applicable | Completed | Changping Laboratory | 36 | 2023-05-29 | 2024-12-16 |
| Feasibility of Neuromodulation With Connectivity-Guided iTBS for Cognitive Impairment in MS Intermittent theta burst stimulation (iTBS), Sham Intermittent theta burst stimulation (iTBS) - Multiple Sclerosis, Cognitive Impairment | Not applicable | Unknown | University of Nottingham | 40 | 2022-06-01 | 2023-06-12 |
| Examining the Effect of EEG-guided Theta Burst Stimulation in Bipolar Disorder Continuous Theta Burst Stimulation (cTBS), Intermittent Theta Burst Stimulation (iTBS) - Bipolar Disorder | Not applicable | Completed | Mary Phillips, MD MD (Cantab) | 13 | 2022-03-23 | 2024-09-19 |
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Depressive Disorder, Major (6) · Depression (4) · Alzheimer Disease (2) · Combat Disorders (2) · Spinal Cord Injuries (2) · Stress Disorders, Post-Traumatic (2) · Stroke (2) · Alcoholism (1) · Antisocial Personality Disorder (1) · Anxiety Disorders (1) · Attention Deficit Disorder with Hyperactivity (1) · Bipolar Disorder (1) · Chronic Pain (1) · Cognitive Dysfunction (1) · Death (1)
The Hong Kong Polytechnic University (4) · Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA (2) · Massachusetts General Hospital (2) · University Hospital, Bonn (2) · Ankara Etlik City Hospital (1) · Bradley Hospital (1) · Bronx VA Medical Center (1) · Changping Laboratory (1) · Gopalkumar Rakesh (1) · Gulhane Training and Research Hospital (1) · Jean-Marie Annoni (1) · Mary Phillips, MD MD (Cantab) (1) · National Institute on Drug Abuse (NIDA) (1) · Ottawa Hospital Research Institute (1) · Shanghai Mental Health Center (1)
United States (12) · Canada (5) · Hong Kong (4) · China (2) · Germany (2) · Turkey (Türkiye) (2) · Switzerland (1) · United Kingdom (1)
Fidel Vila-Rodriguez, M.D., PhD, FRCPC, DFAPA (2) · Fabio Ferrarelli, MD, PhD (1) · Fidel Vila-Rodriguez, MD, PhD (1) · Flavio Frohlich, PhD (1) · Georg Kranz, PhD (1) · Georg S. Kranz (1) · Gopalkumar Rakesh, MD (1) · Hesheng Liu, PhD (1) · James Downar, MDCM, MHSc (1) · Jean-Marie Annoni, Prof. Dr. (1) · Kenneth Fong, PhD (1) · Krista Lanctot, PhD (1) · Mark Eldaief, MD (1) · Mary L Phillips, MD, MD (1) · Matija Milosevic, PhD (1)
PMID 32218749, PMID 32613082, PMID 35317611, PMID 38336341, PMID 38482823
K23MH139637 (1), R01MH129367 (1), R21MH120633 (1), UL1TR001998 (1)