24 completed, 4 terminated, 2 recruiting, 2 unknown. 14 Phase 2, 13 Phase 1, 9 Phase 3, 4 Phase 4.
Follow Inhaled Placebo: new trials by email Literature Review of Inhaled Placebo trials Research Report on Inhaled Placebo
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhaled Isopropyl Alcohol for Treatment of Nausea Inhaled Isopropyl Alcohol, Oral Ondansetron, Inhaled Placebo - Vomiting, Nausea | Phase 2 / Phase 3 | Recruiting | State University of New York at Buffalo | 84 | 2022-04-20 | 2026-09-24 |
| ARrest RESpiraTory Failure From PNEUMONIA Inhaled budesonide and formoterol, Inhaled placebo - Pneumonia, Hypoxemia | Phase 3 | Terminated | Stanford University | 465 | 2020-06-01 | 2026-08-06 |
| A Study of Staccato Loxapine (ADASUVE®) for Inhalation Inhaled loxapine, Inhaled placebo - Psychomotor Agitation, Schizophrenia | Phase 3 | Unknown | Lee's Pharmaceutical Limited | 150 | 2019-12-01 | 2019-11-05 |
| Chronic Pulmonary Aspergillosis and Ambisome Aerosol with Itraconazole inhaled Ambisome®, inhaled placebo, Itraconazole - Chronic Pulmonary Aspergillosis | Phase 3 | Recruiting | Poitiers University Hospital | 224 | 2018-12-19 | 2025-02-20 |
| SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects Inhaled AR-501, Inhaled Placebo - Cystic Fibrosis | Phase 1 / Phase 2 | Unknown | Aridis Pharmaceuticals, Inc. | 102 | 2018-12-07 | 2023-03-09 |
| A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis Inhaled SNSP113, Inhaled Placebo - Lung Diseases, Pulmonary Disease | Phase 1 | Terminated | Synspira, Inc. | 32 | 2017-09-28 | 2018-05-25 |
| Inhaled vs IV Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department inhaled titration of morphine chlorhydrate, IV placebo, Inhaled placebo - Pain, Acute, Emergencies | Phase 3 | Completed | University Hospital, Rouen | 226 | 2017-09-19 | 2026-02-06 |
| Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia Inhaled amikacin, Inhaled placebo - Pneumonia, Ventilator-Associated | Phase 3 | Completed | University Hospital, Tours | 850 | 2017-07-19 | 2025-12-22 |
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration inhaled molgramostim (rhGM-CSF), inhaled placebo - ARDS | Phase 2 | Completed | University of Giessen | 45 | 2016-06-01 | 2023-08-31 |
| Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department Inhaled isopropyl alcohol, Oral ondansetron, Inhaled normal saline - Nausea | Phase 4 | Completed | Brooke Army Medical Center | 122 | 2016-01-01 | 2020-07-23 |
| Iloprost for Bridging to Heart Transplantation in PH Inhaled Iloprost, Placebo - Chronic Left Ventricular Failure, Pulmonary Hypertension | Phase 2 | Withdrawn | Heidelberg University | 2015-02-01 | 2019-12-23 | |
| RCT (Randomized Control Trial) of TD139 vs Placebo in HV's (Human Volunteers) and IPF Patients Inhaled TD139, Placebo - Idiopathic Pulmonary Fibrosis | Phase 1 / Phase 2 | Completed | Galecto Biotech AB | 60 | 2014-09-01 | 2023-11-07 |
| Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years Inhaled Mannitol, Inhaled Placebo - Cystic Fibrosis | Phase 2 | Completed | Syntara | 95 | 2013-06-01 | 2015-10-14 |
| ADASUVE-Lorazepam Drug-Drug Interaction Lorazepam 1 mg IM, Inhaled loxapine 10 mg, Inhaled Placebo - Healthy Volunteers | Phase 4 | Completed | Alexza Pharmaceuticals, Inc. | 22 | 2013-06-01 | 2017-12-13 |
| ADASUVE 2-dose Thorough QT/QTc Study ADASUVE 10 mg 2 doses 2 hours apart, Inhaled Placebo, Oral moxifloxacin 400 mg - Healthy Volunteers | Phase 4 | Completed | Alexza Pharmaceuticals, Inc. | 60 | 2013-05-01 | 2017-10-18 |
| Efficacy and Safety of Two Doses of Formoterol Fumarate MDI (PT005) in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD), Compared to Foradil® Aerolizer® as an Active Control Inhaled PT005, Inhaled Placebo, Formoterol Fumarate 12 µg (Foradil Aerolizer) - COPD | Phase 2 | Withdrawn | Pearl Therapeutics, Inc. | 2010-07-01 | 2014-07-11 | |
| Staccato Loxapine Pulmonary Safety in Patients With COPD Inhaled Loxapine, Inhaled Placebo - Chronic Obstructive Pulmonary Disease | Phase 1 | Completed | Alexza Pharmaceuticals, Inc. | 53 | 2009-06-01 | 2017-03-14 |
| Staccato Loxapine Thorough QT/QTc Study Inhaled loxapine, Inhaled placebo, Oral moxifloxacin - Thorough QT/QTc Study | Phase 1 | Completed | Nova Pneuma Inc. | 48 | 2009-04-01 | 2026-04-22 |
| Study to Evaluate the Safety and Efficacy of Inhaled PT001 in Patients With Chronic Obstructive Pulmonary Disease (COPD) Inhaled PT001, Inhaled Placebo, Tiotropium Handihaler - Chronic Obstructive Pulmonary Disease | Phase 1 / Phase 2 | Completed | Pearl Therapeutics, Inc. | 33 | 2009-03-01 | 2013-06-21 |
| Staccato Loxapine in Migraine (Out Patient) Inhaled Placebo, Inhaled Loxapine 1.25 mg, Inhaled Loxapine 2.5 mg - Migraine Headache | Phase 2 | Completed | Alexza Pharmaceuticals, Inc. | 366 | 2009-01-01 | 2017-04-24 |
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Pulmonary Disease, Chronic Obstructive (5) · Psychomotor Agitation (4) · Cystic Fibrosis (3) · Migraine Disorders (3) · Pneumonia (3) · Schizophrenia (3) · Hypertension, Pulmonary (2) · Nausea (2) · Acute Lung Injury (1) · Acute Pain (1) · Bipolar Disorder (1) · Breakthrough Pain (1) · Burkholderia Infections (1) · Cardiotoxicity (1) · Emergencies (1)
Alexza Pharmaceuticals, Inc. (13) · Pearl Therapeutics, Inc. (3) · Nova Pneuma Inc. (2) · Actelion (1) · Aridis Pharmaceuticals, Inc. (1) · Brooke Army Medical Center (1) · Galecto Biotech AB (1) · Heidelberg University (1) · Hospital Son Llatzer (1) · Lee's Pharmaceutical Limited (1) · Poitiers University Hospital (1) · Stanford University (1) · State University of New York at Buffalo (1) · Synspira, Inc. (1) · Syntara (1)
United States (21) · France (3) · United Kingdom (3) · Germany (2) · Australia (1) · Netherlands (1) · New Zealand (1) · Spain (1)
Colin Reisner, M.D. (2) · Daniel A Spyker, MD (2) · Randall R Stoltz, MD (2) · Robert S Fishman, MD (2) · Aina Noguera, Medicine (1) · Alan H Cohen, MD (1) · Alana Koehler, MD (1) · Amanda Iglesias, Biology (1) · Angel Rios, Nursing (1) · Anne Munck, Dr (1) · Antonia Fuster, PhD Medicine (1) · Arthur Elkind, MD (1)
PMID 29163985, PMID 21294997, PMID 24375070, PMID 25027304, PMID 25060541, PMID 26445139, PMID 27022468, PMID 29463461, PMID 30975187, PMID 32738928, PMID 33214209, PMID 33493423, PMID 34521664, PMID 37888914
1UG3HL141722-01A1 (1)