12 completed, 3 unknown, 2 recruiting, 1 terminated. 3 Not applicable, 2 Phase 1, 2 Phase 2, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Burkholderia Infections: new trials by email Literature Review of Burkholderia Infections trials Research Report on Burkholderia Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Environment, Pathogens, and Host Interactions in Melioidosis Melioidosis | Recruiting | University of Oxford | 2400 | 2026-08-19 | 2026-09-18 | |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| An Observational Study to Evaluate Clinical Characteristics of Adult Patients With Suspected or Confirmed Melioidosis Observational Study - Melioidosis | Completed | AN2 Therapeutics, Inc | 200 | 2023-11-01 | 2025-05-31 | |
| Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis Ceftolozane/tazobactam - Bronchiectasis, Cystic Fibrosis | Phase 4 | Unknown | Sunshine Coast Hospital and Health Service | 30 | 2023-10-01 | 2023-09-13 |
| Oral ARV-1801 Given in Combination With Intravenous Ceftazidime or Meropenem for Treatment of Melioidosis in Hospitalized Patients Ceftazidime or meropenem, ARV-1801, Placebo - Melioidosis | Phase 2 | Completed | Arrevus Inc. | 125 | 2022-06-14 | 2024-02-16 |
| Diagnostic Accuracy of the DPP II Assay DPP Fever Panel II assay - Acute Febrile Illness, Melioidosis | Completed | Foundation for Innovative New Diagnostics, Switzerland | 104 | 2019-10-28 | 2023-11-30 | |
| Causes of Pneumonia in Yangon InBios® Active Melioidosis DetectTM-Lateral Flow Assay - Melioidosis Pneumonia | Completed | Myanmar Oxford Clinical Research Unit | 300 | 2018-07-09 | 2020-01-13 | |
| Adapting LFI for Melioidosis Lateral flow immunoassay - Melioidosis | Completed | Duke University | 100 | 2018-06-21 | 2019-08-01 | |
| A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis Inhaled SNSP113, Inhaled Placebo - Lung Diseases, Pulmonary Disease | Phase 1 | Terminated | Synspira, Inc. | 32 | 2017-09-28 | 2018-05-25 |
| Clinical Presentation of Melioidosis in Head and Neck Region Patient who presented with melioidosis in head and neck - Melioidosis, Head and Neck Infection | Unknown | Khon Kaen University | 48 | 2017-01-01 | 2017-02-10 | |
| Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis Venous blood sampling (2 timepoints) (Phase A and B), Venous blood sampling (1 timepoint) (Phase A and B), Voided urine sampling (first sample) (Phase A) - Melioidosis, Systemic Inflammatory Response Syndrome | Completed | Institute of Tropical Medicine, Belgium | 4203 | 2016-02-01 | 2018-10-23 | |
| A Study of OligoG in Cystic Fibrosis Subjects With Burkholderia Spp. Infection Alginate oligosaccharide, Placebo - Cystic Fibrosis, Burkholderia Infection | Phase 2 | Completed | AlgiPharma AS | 15 | 2015-02-01 | 2018-04-19 |
| Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Patients Infected With Burkholderia Cepacia Complex TOBI - Cystic Fibrosis, Burkholderia Cepacia Infection | Phase 1 | Completed | Unity Health Toronto | 10 | 2014-09-01 | 2020-11-04 |
| A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand An educational programme for prevention of melioidosis - Melioidosis | Not applicable | Completed | University of Oxford | 9075 | 2014-04-01 | 2021-07-21 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) rk28 ICT, IT LEISH (rK39), Immunochromatographic HAT test - Visceral Leishmaniasis, Human African Trypanosomiasis | Not applicable | Completed | University Hospital, Geneva | 1927 | 2013-01-01 | 2016-10-27 |
| Co-trimoxazole as Maintenance Therapy for Melioidosis Co-trimoxazole 12, Co-trimoxazole 20 - Melioidosis | Phase 4 | Completed | Khon Kaen University | 667 | 2011-08-01 | 2020-09-03 |
| Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia Species Infection AZLI, Placebo - Cystic Fibrosis, Burkholderia Infections | Phase 3 | Completed | Gilead Sciences | 102 | 2010-02-01 | 2014-03-11 |
| A Randomized Double Blinded Comparison of Ceftazidime and Meropenem in Severe Melioidosis Meropenem, Ceftazidime - Melioidosis | Not applicable | Unknown | University of Oxford | 750 | 2007-12-01 | 2008-06-04 |
Melioidosis (13) · Cystic Fibrosis (5) · Brucellosis (2) · Leptospirosis (2) · Malaria (2) · Pneumonia (2) · Adenoviridae Infections (1) · Arenaviridae Infections (1) · Bronchiectasis (1) · Bunyaviridae Infections (1) · Caliciviridae Infections (1) · Chickenpox (1) · Chikungunya Fever (1) · Chlamydia Infections (1)
Bacterial Infections (18) · Bacterial Infections and Mycoses (18) · Gram-Negative Bacterial Infections (18) · Infections (17) · Digestive System Diseases (7) · Respiratory Tract Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Infant, Newborn, Diseases (5) · Lung Diseases (5) · Pancreatic Diseases (5) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Gram-Positive Bacterial Infections (3)
Ceftazidime (2) · Meropenem (2) · Blood Specimen Collection (1) · Observation (1) · ceftolozane, tazobactam drug combination (1) · oligoG CF-5-20 (1)
University of Oxford (3) · Khon Kaen University (2) · AN2 Therapeutics, Inc (1) · AlgiPharma AS (1) · Arrevus Inc. (1) · Duke University (1) · Foundation for Innovative New Diagnostics, Switzerland (1) · Gilead Sciences (1) · Institut Pasteur du Cambodge (1) · Institute of Tropical Medicine, Belgium (1) · Myanmar Oxford Clinical Research Unit (1) · Sunshine Coast Hospital and Health Service (1) · Synspira, Inc. (1) · Unity Health Toronto (1) · University Hospital, Geneva (1)
Thailand (7) · Cambodia (4) · Canada (2) · Laos (2) · Australia (1) · Burma (1) · Democratic Republic of the Congo (1) · Germany (1) · Malaysia (1) · Nepal (1) · Sudan (1) · United Kingdom (1) · United States (1)
Alistair McLean, Dr (1) · Andrew Burke, MBBS (1) · Assist Prof. Direk Limmathurotsakul, M.D. (1) · Clare Warrell, Dr (1) · Claude Flamand, Ph.D. (1) · David Dance, Prof (1) · Elizabeth A Ashley, Dr (1) · Frank Smithuis, Prof (1) · Gregory C Gray, MD, MPH (1) · Jan Jacobs, MD (1) · Julia J Bashford, BSc, MBBS (1) · Kamolchanok Claire Chewapreecha, PhD (1) · Kyaw Soe (1) · Maria Theresa Basco, MD, MPH (1)
PMID 25359677, PMID 27812090, PMID 28262569, PMID 2926159, PMID 32671834, PMID 32725199, PMID 34170931, PMID 35086790, PMID 35491421