31 completed, 3 withdrawn, 1 not yet recruiting, 1 terminated. 25 Phase 1, 6 Phase 2, 2 Phase 3, 2 Phase 4, 1 Early Phase 1.
Follow Gemfibrozil: new trials by email Literature Review of Gemfibrozil trials Research Report on Gemfibrozil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients. Gemfibrozil, Placebo - Parkinson Disease | Phase 2 | Withdrawn | Forest Hills Lab | 2027-11-01 | 2026-08-19 | |
| Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of PLX-200 in Pediatric Patients (Master Protocol) PLX-200 - Lysosomal Storage Disorders, Sandhoff Disease | Phase 2 | Not yet recruiting | Polaryx Therapeutics, Inc. | 24 | 2026-12-01 | 2026-07-31 |
| Safety, Tolerability, and Efficacy of PLX-200 in Patients With CLN3 PLX-200, Placebo - Juvenile Neuronal Ceroid Lipofuscinosis | Phase 3 | Withdrawn | Polaryx Therapeutics, Inc. | 2026-11-01 | 2026-08-19 | |
| A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compound RO7795081 RO7795081, Itraconazole, Gemfibrozil - Healthy Participants | Phase 1 | Completed | Hoffmann-La Roche | 36 | 2025-02-13 | 2026-09-28 |
| A Phase 1, Open-label Study Evaluating the Pharmacokinetics and Drug-drug Interaction of VX-993 in Healthy Adults VX-993, Gemfibrozil, Itraconazole - Pain | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 42 | 2024-05-02 | 2024-08-01 |
| Evaluation of the Potential Drug-drug Interactions Between Gemfibrozil or Dabigatran Etexilate and Camlipixant Camlipixant, Dabigatran etexilate, Gemfibrozil - Cough, Healthy | Phase 1 | Completed | Bellus Health Inc. - a GSK company | 45 | 2023-07-26 | 2025-03-26 |
| A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants BMS-986278, Itraconazole, Gemfibrozil - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 47 | 2023-07-12 | 2023-10-30 |
| A Study to Assess the Effect of Itraconazole, Phenytoin and Gemfibrozil on the Drug Levels of BMS-986166 in Healthy Participants BMS-986166, Itraconazole, Extended Phenytoin Sodium - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 15 | 2021-07-28 | 2022-05-13 |
| A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects SKLB1028, Itraconazole, Gemfibrozil - Healthy Subjects | Phase 1 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 42 | 2021-06-07 | 2021-10-06 |
| Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects Tolebrutinib, gemfibrozil, rifampicin - Multiple Sclerosis | Phase 1 | Completed | Sanofi | 30 | 2020-05-18 | 2025-09-17 |
| A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone Omaveloxolone, Midazolam oral solution, Repaglinide 1 MG - Healthy Adult Subjects | Phase 1 | Completed | Biogen | 61 | 2019-06-14 | 2025-05-30 |
| A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib tucatinib, itraconazole, rifampin - Drug-drug Interaction | Phase 1 | Completed | Seagen Inc. | 116 | 2018-09-17 | 2019-12-18 |
| Drug-drug Interaction Study of Ozanimod With Inhibitor or Inducer of CYP2C8 and/or CYP3A Ozanimod, Gemfibrozil, Itraconazole - Healthy Volunteer | Phase 1 | Completed | Celgene | 100 | 2018-06-20 | 2019-05-30 |
| Exploration of Gemfibrozil as a Treatment for AUD Gemfibrozil 600 MG, Placebo oral capsule - Alcohol Use Disorder | Phase 2 | Terminated | The Mind Research Network | 3 | 2018-05-16 | 2021-10-29 |
| A Clinical Study to Investigate the Effect of Gemfibrozil or Rifampicin on Blood Concentrations of Selexipag in Healthy Subjects Selexipag, Gemfibrozil, Rifampicin - Healthy Subjects | Phase 1 | Completed | Actelion | 40 | 2016-06-01 | 2025-02-03 |
| Gemfibrozil for Nicotine Smoking Cessation Gemfibrozil, smoking cessation counseling - Smoking Cessation | Phase 2 | Completed | University of Texas Southwestern Medical Center | 16 | 2015-02-01 | 2019-02-01 |
| Study to Assess Drug-Drug Interaction Between Itraconazole or Gemfibrozil and JNJ-56021927 JNJ-56021927, Itraconazole, Gemfibrozil - Healthy | Phase 1 | Completed | Aragon Pharmaceuticals, Inc. | 45 | 2014-09-01 | 2016-10-20 |
| Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease Gemfibrozil, Placebo - Preclinical Alzheimer's Disease | Early Phase 1 | Completed | Gregory Jicha, 323-5550 | 72 | 2014-05-01 | 2019-10-08 |
| Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction Gemfibrozil, Placebo - Nicotine Dependence | Phase 2 | Completed | Centre for Addiction and Mental Health | 28 | 2014-02-01 | 2017-04-20 |
| The Effect of Gemfibrozil, Ketoconazole and Clarithromycin on the Amount of LY2409021 in the Bloodstream LY2409021, Gemfibrozil, Ketoconazole - Healthy Volunteers | Phase 1 | Completed | Eli Lilly and Company | 30 | 2013-05-01 | 2019-03-08 |
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Alzheimer Disease (2) · Coronary Disease (2) · Diabetes Mellitus, Type 2 (2) · Alcoholism (1) · Anemia (1) · Atherosclerosis (1) · Cardiovascular Diseases (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Cough (1) · HIV Infections (1) · Heart Diseases (1) · Hyperlipidemias (1) · Hypertriglyceridemia (1) · Idiopathic Pulmonary Fibrosis (1)
Astellas Pharma Europe B.V. (2) · Bristol-Myers Squibb (2) · Eli Lilly and Company (2) · GlaxoSmithKline (2) · National Institutes of Health Clinical Center (CC) (2) · Polaryx Therapeutics, Inc. (2) · Actelion (1) · Aragon Pharmaceuticals, Inc. (1) · AstraZeneca (1) · Bellus Health Inc. - a GSK company (1) · Biogen (1) · Blu Caribe (1) · Boehringer Ingelheim (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1) · Celgene (1)
United States (16) · Canada (3) · United Kingdom (3) · Netherlands (2) · Australia (1) · China (1) · France (1) · Germany (1) · India (1) · Sweden (1) · Taiwan (1)
Alex Vo, PhD (1) · Aslak Rautio (1) · Bernard Le Foll, MD, PhD (1) · Erin Nulf, RN, BSN (1) · Frank Sacks (1) · Gregor Theilmeier, MD (1) · Gregory A Jicha, MD, PhD (1) · Hanna E. Bloomfield, MD MPH (1)
PMID 10438259, PMID 12117730, PMID 12456232, PMID 19648824, PMID 24491572, PMID 25929560, PMID 28715853, PMID 32857315, PMID 35931943, PMID 39368039, PMID 8806347, PMID 9778079
2016 (1), R01HL036392 (1)