54 completed, 17 unknown, 7 recruiting, 4 active not recruiting. 94 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 94 | Completed 54, Unknown 17, Recruiting 7, Active not recruiting 4, Not yet recruiting 4, Terminated 4, Withdrawn 3, Enrolling by invitation 1 |
Follow Ezetimibe: new trials by email Literature Review of Ezetimibe trials Research Report on Ezetimibe
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial Rosuvastatin, Ezetimibe, Recaticimab - Intracranial Arteriosclerosis, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 440 | 2026-09-17 | 2026-09-15 |
| Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome Inclisiran, Atorvastatin or Rosuvastatin, Ezetimibe - Acute Coronary Syndromes (ACS) | Phase 4 | Not yet recruiting | Seoul National University Bundang Hospital | 294 | 2026-09-01 | 2026-09-02 |
| Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome bempedoic acid, Ezetimibe, High-Intensity Statin Therapy - Acute Coronary Syndromes, Dyslipidemia | Phase 4 | Recruiting | Taipei Medical University Hospital | 400 | 2026-08-26 | 2026-09-17 |
| Ezetimibe for Arrhythmia Recurrence After AF Ablation Ezetimibe, Standardized post-ablation clinical management - Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2026-08-15 | 2026-08-07 |
| Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome Atorvastatin 40 Mg Oral Tablet, Ezetimibe 10 mg, Bempedoic Acid 180 MG Oral Tablet - Acute Coronary Syndromes (ACS), Hypercholesterolemia | Phase 4 | Not yet recruiting | Punjab Institute of Cardology | 120 | 2026-05-01 | 2026-04-09 |
| Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL Cholesterol Rosuvastatin + Ezetimibe, Bempedoic Acid + Ezetimibe, Rosuvastatin + Ezetimibe + Bempedoic Acid - Type 2 Diabetes Mellitus, Hypercholesterolemia / Elevated LDL Cholesterol | Phase 4 | Completed | Bahria University | 126 | 2026-01-01 | 2026-10-20 |
| GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification Pitavastatin 4mg and ezetimibe 10mg, taken once daily, Pitavastatin 2 mg with aspirin 100 mg, taken once daily. - Primary Prevention, Vascular Calcification | Phase 4 | Recruiting | Asan Medical Center | 7435 | 2025-07-09 | 2025-08-07 |
| LDL Cholesterol Reduction Following Ezetimibe Initiation Ezetimibe - Atherosclerotic Cardiovascular Disease (ASCVD), Cardiovascular Risk | Phase 4 | Recruiting | Universidade do Porto | 100 | 2025-06-01 | 2026-09-24 |
| Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque Stabilization Rosuvastatin, Rosuvastatin/ezetimibe - Coronary Artery Disease, Atherosclerosis of Coronary Artery | Phase 4 | Active not recruiting | Korea University Anam Hospital | 410 | 2025-05-12 | 2026-10-26 |
| Efficacy and Safety of Atorvastatin and Ezetimibe (10/10mg) Fixed Dose Combination Versus Atorvastatin (20mg) Monotherapy in Bangladeshi Population Atorvastatin 10 mg and ezetimibe 10 mg, Atorvastatin 20 mg - Hyperlipidemia (E.G., Hypercholesterolemia) | Phase 4 | Withdrawn | Dr. Md. Alimur Reza | 2025-02-01 | 2026-10-07 | |
| Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe, Lipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe - Dyslipidemias, Statin Adverse Reaction | Phase 4 | Unknown | University of Salerno | 130 | 2024-05-01 | 2024-04-24 |
| Effect of Ezetimibe on Gut Microbiota Atorvastatin 40mg, Atorvastatin 20mg+Ezetimibe 10mg - Atherosclerotic Cardiovascular Disease With Dyslipidemia | Phase 4 | Recruiting | Yonsei University | 110 | 2024-02-28 | 2025-01-20 |
| Long-term Comparison of Pitavastatin/Ezetimibe and Pitavastatin in Patients With Hypercholesterolemia and Elevated Triglycerides Pitavastatin 4mg, Ezetimibe 10 mg, Placebo (for Pitavastatin/Ezetimibe) - Hypercholesterolemia | Phase 4 | Active not recruiting | JW Pharmaceutical | 88 | 2023-08-21 | 2026-03-02 |
| Comparative Study of Rosuvastatin/Ezetimib 20/10 mg and Atovastatin/Ezetimib 40/10 mg (TOLERANT Trial) a high dose of statin/ezetimib - Coronary Artery Disease, Dyslipidemias | Phase 4 | Active not recruiting | Yonsei University | 200 | 2023-05-03 | 2025-11-25 |
| Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus (PROVE-DM) high-intensity statin arm, low-intensity statin plus ezetimibe - Pre Diabetes, ASCVD | Phase 4 | Enrolling by invitation | Seung-Whan Lee, M.D., Ph.D. | 4000 | 2023-03-14 | 2026-01-07 |
| Cholesterol Lowering and Residual Risk in Diabetes, Type 1 Evolocumab Cartridge, Atorvastatin Calcium Tablets, Ezetimibe Tablets - Type 1 Diabetes | Phase 4 | Recruiting | NYU Langone Health | 125 | 2022-12-06 | 2026-10-28 |
| Effect of Early Initiation of Evolocumab on Lipid Profiles Changes in Patients With ACS Undergoing PCI Evolocumab 140 MG/ML, Rosuvastatin 5mg, Ezetimibe 10mg - Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia | Phase 4 | Completed | Yonsei University | 108 | 2022-12-01 | 2025-03-13 |
| A Multicenter Study to Evaluate the Effect of High Dose Rosuvastatin Versus Rosuvastatin and Ezetimibe in Stroke combination of high-dose rosuvastatin and ezetimibe, high-dose rosuvastatin single administration - Dyslipidemias, Stroke, Acute Ischemic | Phase 4 | Unknown | Korea University Anam Hospital | 330 | 2022-09-01 | 2023-06-01 |
| Statin and Bone Health Simvastatin 10mg, Ezetimibe 10mg - Diabetes Mellitus, Type 2 | Phase 4 | Unknown | The University of Hong Kong | 240 | 2022-04-13 | 2022-11-28 |
| Cholesterol Lowering Via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome Study Bempedoic Acid / Ezetimibe Oral Tablet, Placebo - Cardiovascular Diseases, NSTEMI | Phase 4 | Unknown | Kaiser Permanente | 500 | 2022-03-01 | 2022-03-03 |
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Hypercholesterolemia (35) · Coronary Artery Disease (16) · Dyslipidemias (13) · Atherosclerosis (12) · Cardiovascular Diseases (8) · Hyperlipidemias (8) · Acute Coronary Syndrome (7) · Diabetes Mellitus, Type 2 (7) · Coronary Disease (6) · Diabetes Mellitus (5) · ST Elevation Myocardial Infarction (4) · Lipid Metabolism Disorders (3) · Metabolic Syndrome (3) · Myocardial Infarction (3) · Non-ST Elevated Myocardial Infarction (3)
Organon and Co (16) · Yonsei University (4) · Korea University Anam Hospital (3) · University of Roma La Sapienza (3) · Baylor College of Medicine (2) · NYU Langone Health (2) · Policlinico Casilino ASL RMB (2) · Sanofi (2) · Asan Medical Center (1) · Bahria University (1) · Bronx VA Medical Center (1) · Collegium Medicum w Bydgoszczy (1) · Daiichi Sankyo (1) · Dr. Md. Alimur Reza (1) · Federal University of Rio Grande do Sul (1)
South Korea (16) · United States (14) · Italy (9) · Germany (4) · China (3) · Japan (3) · United Kingdom (3) · Brazil (2) · Israel (2) · Lebanon (2) · Netherlands (2) · Pakistan (2) · Sweden (2) · Switzerland (2) · Taiwan (2)
Alan S Go, MD (1) · Alejandro Soza, MD (1) · Allen J Taylor, MD (1) · Ana Carolina M Gagliardi, nutritionist (1) · Andrew P Ambrosy, MD (1) · Bashar A Aqel (1) · Carlo Gaudio, MD (1) · Christie Ballantyne, M.D. (1) · Christie M. Ballantyne, MD (1) · Chu-Huang Chen, M.D., Ph.D. (1) · Chun-Yao Huang, MD, PhD (1) · Colin Baigent, FRCP, FFPH (1)
PMID 38018702, PMID 16749654, PMID 16893434, PMID 17407633, PMID 18545068, PMID 18765432, PMID 19075102, PMID 19915217, PMID 20067513, PMID 20399059, PMID 20525999, PMID 20663203, PMID 21122660, PMID 21227624, PMID 21271793, PMID 21663949, PMID 22115011, PMID 22291820, PMID 22564353, PMID 22621316, PMID 22700717, PMID 23013513, PMID 23544125, PMID 23809138, PMID 24023786, PMID 24075764, PMID 24267254, PMID 24503114, PMID 24653510, PMID 24662777, PMID 24720535, PMID 25825402, PMID 25929253, PMID 26208795, PMID 26227186, PMID 26385817, PMID 27318866, PMID 28028192, PMID 28460629, PMID 28545518, PMID 28697767, PMID 28780579, PMID 29436756, PMID 29606415, PMID 29925472, PMID 30420184, PMID 31005271, PMID 31434809, PMID 31662874, PMID 31706300
2004 (1), 2008 (1), 2015 (1), 2018 (1), R01HL075824 (1)