26 completed, 6 unknown, 2 active not recruiting, 2 recruiting. 16 Not applicable, 10 Phase 2, 7 Phase 3, 6 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Menopausal Hormones and Sympathetic Activation Estrogen, Placebo - Perimenopausal Women | Phase 4 | Not yet recruiting | University of Delaware | 80 | 2026-09-01 | 2026-03-27 |
| Effects of Estrogen Therapy on Lipid Metabolism and Insulin Sensitivity in Hypogonadal Women Estrogen - Female Hypogonadism | Not applicable | Active not recruiting | Khyber Medical University Peshawar | 30 | 2025-12-04 | 2026-09-15 |
| Early Neurovascular Adaptations in Aging Women Norepinephrine, Isoproterenol, Acetylcholine - Women, Sympathetic Nervous System | Early Phase 1 | Recruiting | University of Missouri-Columbia | 64 | 2024-09-20 | 2025-11-26 |
| Improving Diagnostics in Cervical Dysplasia Estrogen, Placebo - Cervical Cancer | Not applicable | Recruiting | University of Aarhus | 150 | 2023-08-23 | 2026-07-31 |
| GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy. Estrogen, dehydroepiandrosterone, Estrogen + probiotics - Vulvovaginal Atrophy, Breast Cancer | Phase 4 | Completed | University Hospital, Ghent | 31 | 2022-03-21 | 2026-08-13 |
| Impact of Exogenous Estrogens on Cotisol Levels During Synacthen Stimulation Estrogen - Adrenal Insufficiency, Hypogonadism Female | Not applicable | Unknown | Copenhagen University Hospital, Rigshospitalet | 20 | 2022-01-01 | 2022-03-31 |
| Feminizing Hormone Therapy and the Rectal Mucosa Immune Environment in Transgender Women Estrogen, Estrogen plus Progesterone - HIV Prevention | Completed | Emory University | 285 | 2020-10-01 | 2025-06-17 | |
| Clinical Study of in Situ Regeneration of Endometrium CBD-bFGF, Collagen/BMMNCs, Estrogen - Infertility, Female, of Uterine Origin, Endometrial Fibrosis | Phase 1 / Phase 2 | Unknown | Yali Hu | 345 | 2020-04-29 | 2022-09-28 |
| Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease Anti Mueller hormone, Estrogen, Follicle-Stimulating Hormone - Fertility Disorders, Ovarian Reserve Function | Not applicable | Unknown | Sixth Affiliated Hospital, Sun Yat-sen University | 80 | 2017-05-01 | 2017-09-01 |
| Pregnancy Outcome of Women Using Low Molecular Weight Heparin Before Frozen-thawed Embryo Transfer estrogen, Low Molecular Weight Heparin, hCG - Infertility | Phase 4 | Unknown | Nanfang Hospital, Southern Medical University | 342 | 2016-07-01 | 2017-04-19 |
| A Study to See Whether Estrogen Can Slow the Growth of Some ER Positive Breast Cancers Estradiol - Estrogen Receptor Positive Breast Cancer | Phase 2 | Active not recruiting | AHS Cancer Control Alberta | 19 | 2015-08-01 | 2025-06-26 |
| Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy CO2 laser, Estrogen, Placebo of Estrogen - Vulvovaginal Atrophy | Phase 3 | Completed | Faculdade de Medicina do ABC | 45 | 2015-03-01 | 2016-06-28 |
| The Effect of Different Types of Progestin on Sleeping of Menopausal Women 1mg 17 beta-estradiol, Dydrogesterone, micronized progesterone - Menopausal and Postmenopausal Disorders | Not applicable | Completed | Chiang Mai University | 100 | 2014-01-01 | 2017-05-31 |
| E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy Lisdexamfetamine, Estradiol, Placebo - Planned RRSO | Not applicable | Withdrawn | University of Pennsylvania | 2013-07-01 | 2017-03-24 | |
| Chronic Effects of Estrogen in Microcirculation Estrogen - Postmenopausal Symptoms | Phase 4 | Completed | Rio de Janeiro State University | 44 | 2011-12-01 | 2013-04-18 |
| Effectiveness and Safety Study of Solifenacin Succinate and Solifenacin Succinate + Estrogen to Treat OAB in Postmenopausal Women Solifenacin Succinate Tablets, Estrogen - Overactive Bladder, Postmenopausal Disorder | Phase 4 | Completed | Peking Union Medical College Hospital | 200 | 2011-10-01 | 2014-03-20 |
| North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Sterile saline, Bevacizumab, Estriol - Telangiectasia, Hereditary Hemorrhagic, Epistaxis | Phase 2 | Completed | James Gossage | 123 | 2011-08-01 | 2018-10-19 |
| Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone Metformin, Progesterone, estrace - Polycystic Ovary Syndrome, Hyperandrogenism | Not applicable | Completed | University of Virginia | 25 | 2009-02-18 | 2021-01-08 |
| Bone Mass Accrual in Adolescent Athletes Estrogen - Amenorrhea, Bone Loss | Phase 3 | Withdrawn | Massachusetts General Hospital | 2008-12-01 | 2021-10-26 | |
| Sex Steroids, Sleep, and Metabolic Dysfunction in Women Progesterone, testosterone, glucocorticoid - Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea | Not applicable | Completed | Washington University School of Medicine | 61 | 2007-09-01 | 2018-08-01 |
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Alzheimer Disease (4) · Cardiovascular Diseases (4) · Polycystic Ovary Syndrome (3) · Coronary Disease (2) · Heart Diseases (2) · Infertility (2) · Insulin Resistance (2) · Myocardial Infarction (2) · Myocardial Ischemia (2) · Obesity (2) · Turner Syndrome (2) · Adrenal Insufficiency (1) · Amenorrhea (1) · Atherosclerosis (1) · Bone Diseases, Metabolic (1)
National Center for Research Resources (NCRR) (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · National Institute on Aging (NIA) (3) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · University of California, Los Angeles (2) · University of Virginia (2) · Washington University School of Medicine (2) · AHS Cancer Control Alberta (1) · Chiang Mai University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Eli Lilly and Company (1) · Emory University (1) · Faculdade de Medicina do ABC (1) · James Gossage (1) · Khyber Medical University Peshawar (1)
United States (25) · China (4) · Brazil (2) · Canada (2) · Denmark (2) · Belgium (1) · Pakistan (1) · Thailand (1)
Anne Cross, M.D. (1) · Anthony Reder, M.D. (1) · B. Lawrence Riggs, M.D. (1) · Barbara Giesser, M.D. (1) · Bettina Mittendorfer, PhD (1) · C. Neill Epperson, MD (1) · Cathy C Lee, PhD (1) · Chris McCartney, MD (1) · Colleen Kelley, MD, MPH (1) · Corey Ford, M.D. (1) · Dean Wingerchuk, M.D. (1) · Dina Jacobs, M.D. (1) · Diogo Panazzolo (1) · Dr. Pauline Maki (1)
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