Early Neurovascular Adaptations in Aging Women

NCT06520982 — Early Phase 1, Recruiting, 64 participants, University of Missouri-Columbia

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Registry	NCT06520982
Status	Recruiting
Phase	Early Phase 1
Study type	Interventional; na, single group, masking: none, basic science
Enrollment	64 (Estimated)
Sponsor	University of Missouri-Columbia (Other); collaborators: American Heart Association
Conditions	Women, Sympathetic Nervous System, Aging, Blood Flow
Interventions	Norepinephrine, Isoproterenol, Acetylcholine, Nitroprusside, Estrogen (Drug)
Dates	start 2024-09-20, primary completion 2027-06-30 (estimated), completion 2028-06-30 (estimated), first posted 2024-07-25, last updated 2025-11-26
Locations	1 site in United States

-Summary

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

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+Arms and interventions

Arm	Type	Interventions	Description
Women	Other	Drug: Norepinephrine; Drug: Isoproterenol; Drug: Acetylcholine; Drug: Nitroprusside; Drug: Estrogen	Women will be 18-70 years of age

Norepinephrine (Drug): Infused intra-arterially in a dose-response fashion
Isoproterenol (Drug): Infused intra-arterially in a dose-response fashion
Acetylcholine (Drug): Infused intra-arterially in a dose-response fashion
Nitroprusside (Drug): Infused intra-arterially in a dose-response fashion
Estrogen (Drug): Infused intra-arterially

+Outcome measures

Primary outcomes

Magnitude of forearm blood flow [Change from baseline during infusion]

+Eligibility

Sex: Female, ages: 18 Years to 70 Years, accepts healthy volunteers

Inclusion Criteria:

* Assigned female at birth (AFAB)
* 18-70 years of age

Exclusion Criteria:

* Assigned male at birth (AMAB)
* Pregnancy, breastfeeding
* Body mass index ≥30 kg/m2
* Taking medications known to affect metabolic, autonomic, and/or respiratory function
* Oral hormonal contraception in last 6 month
* History of hormone replacement therapy
* History of hyster- or oophor-ectomy
* Current smoking/Nicotine use
* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
* Chronic disease
* Blood pressure ≥140/90 mmHg
* Communication barriers

+Locations (1)

Facility	City	Country	Status
University of Missouri-Columbia	Columbia, Missouri	United States	Recruiting