12 completed, 4 active not recruiting, 3 unknown, 2 not yet recruiting. 20 Not applicable, 2 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 20 | Completed 10, Active not recruiting 4, Not yet recruiting 2, Recruiting 2, Unknown 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 2 | 1 | Unknown 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Erythritol: new trials by email Literature Review of Erythritol trials Research Report on Erythritol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Xylitol- Versus Erythritol-Sweetened Mints on Plaque ATP-Bioluminescence Readings Xylitol, Erythritol - Dental Caries, Dental Plaque | Not applicable | Not yet recruiting | Loma Linda University | 80 | 2026-12-01 | 2026-10-28 |
| Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects Saccharin, Sucralose, Erythritol - Prediabetic State, Metabolic Syndrome | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2026-01-05 | 2026-01-29 |
| The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility specialized food based on ice cream, order 1, specialized food based on ice cream, order 2, specialized food based on ice cream, order 3 - Ineffective Esophageal Motility, GERD (Gastroesophageal Reflux Disease) | Not applicable | Recruiting | Federal State Budgetary Scientific Institution | 30 | 2025-07-01 | 2025-08-14 |
| Effects of GLP-1 Formula on GLP-1 and Glucose Regulation GLP-1 formula Group - Overweight | Not applicable | Recruiting | Shih Chien Huang | 100 | 2025-06-02 | 2025-07-24 |
| Efficacy and Tolerability of a Specialized Food Products for Dietary Therapeutic and Preventive Nutrition Based on Ice Cream (Ice Cream With Brazzein, Maltitol and Oligofructose; Ice Cream With Brazzein, Erythritol, Maltitol and Inulin) Compared to Standard (Sundae) Ice Cream specialized food product based on ice cream, specialized food product based on ice cream 2, specialized food product based on ice cream 3 - Non-Alcoholic Steatohepatitis (NASH), Diabetes Mellitus Type 2 (T2DM) | Not applicable | Active not recruiting | Federal State Budgetary Scientific Institution | 100 | 2025-06-01 | 2025-12-18 |
| Erythritol Air Polishing in Mucositis Treatment Air-polishing with erythritol at different time points, Single Air-polishing with erythritol - Peri-implant Mucositis | Not applicable | Unknown | University of Coimbra | 24 | 2024-03-18 | 2024-06-12 |
| The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation Erythritol, Aspartame - Platelet Aggregation, Spontaneous, Vascular Thrombosis | Not applicable | Active not recruiting | University of California, Davis | 14 | 2023-07-20 | 2026-09-14 |
| Prevention and Arrest of Root Caries Lesions with High Fluoride Concentration Mouthwash Versus Normal Fluoride Concentration Mouthwash in Elderly Patients regular fluoride 220 ppm F mouthwash without erythritol, regular fluoride 220 ppm F mouthwash with erythritol, high fluoride 500 ppm F mouthwash with erythritol - Root Caries | Not applicable | Active not recruiting | Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS | 69 | 2023-02-01 | 2024-12-09 |
| Assessment of Reward Responses to Erythritol Using Flavor Preference Learning Erythritol, Sucrose, Sucralose - Reward Responses, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2022-03-17 | 2022-10-12 |
| Effect of Daily Erythritol Versus Sucrose Intake Over 5 Weeks on Glucose Tolerance in Adolescents Erythritol, Sucrose, Glucose - Insulin Resistance, Glucose Tolerance | Not applicable | Active not recruiting | University Hospital, Basel, Switzerland | 30 | 2021-08-18 | 2026-09-30 |
| Consumption of Oral Artificial Sweeteners on Platelet Aggregation and Polyol Excretion xylitol, 30g, erythritol, 30g, xylitol, 5g - Cardiovascular Risk Factor | Not applicable | Completed | The Cleveland Clinic | 50 | 2021-03-10 | 2026-07-13 |
| Effects of Oral Pre-loads on Subsequent Energy Intake Erythritol, Sucrose, Sucralose - Energy Intake, Gastrointestinal Hormones | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2021-02-05 | 2021-12-16 |
| Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism Erythritol, Erythritol + lactisole, D-allulose - Physiological Satiation Mechanisms | Not applicable | Completed | University Hospital, Basel, Switzerland | 18 | 2019-09-01 | 2020-09-29 |
| Assessment of Satiety Following Oral Administration of an Erythritol Sweetened Beverage Erythritol, Aspartame - Satiety in Healthy Volunteers | Not applicable | Completed | University of Florida | 12 | 2017-09-18 | 2019-08-28 |
| Effect of Different Concentrations of Xylitol and Erythritol on Gut Peptide Release and Gastric Emptying in Humans Xylitol 7g, Erythritol 10g, Xylitol 17g - Physiological Satiation Mechanisms | Not applicable | Completed | University Hospital, Basel, Switzerland | 24 | 2017-02-24 | 2018-09-17 |
| Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects D-allulose, erythritol - Obesity | Not applicable | Unknown | Chiang Mai University | 60 | 2016-09-01 | 2016-12-12 |
| Effect of the Natural Sweeteners Erythritol and Xylitol on Gut Microbiota and Glucose Metabolism in Obese Volunteers E967-Xylitol, E968-Erythritol - Obesity | Not applicable | Completed | University Hospital, Basel, Switzerland | 64 | 2016-06-01 | 2025-07-20 |
| Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions 1.56 g L-Tryptophan, 1.56 g L-Leucine, 50 g Xylitol - Endocrine System Diseases | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2014-05-01 | 2017-02-28 |
| Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans 0.52 g L-Tryptophan, 1.56 g L-Tryptophan, 1.56 g L-Leucine - Endocrine System Diseases | Not applicable | Completed | University Hospital, Basel, Switzerland | 20 | 2014-05-01 | 2015-09-30 |
| The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis metronidazole gel, ultrasonics, erythritol - Periodontal Pocket | Phase 4 | Completed | Proed, Torino, Italy | 20 | 2013-12-01 | 2016-09-02 |
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Diabetes Mellitus, Type 2 (3) · Insulin Resistance (3) · Dental Caries (2) · Endocrine System Diseases (2) · Obesity (2) · Thrombosis (2) · Cardiovascular Diseases (1) · Dental Plaque (1) · Gastroesophageal Reflux (1) · Metabolic Syndrome (1) · Non-alcoholic Fatty Liver Disease (1) · Overweight (1) · Peri-Implantitis (1) · Periodontal Pocket (1) · Periodontitis (1)
University Hospital, Basel, Switzerland (8) · Federal State Budgetary Scientific Institution (2) · Proed, Torino, Italy (2) · Boston University (1) · Charite University, Berlin, Germany (1) · Chiang Mai University (1) · Loma Linda University (1) · Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS (1) · Shih Chien Huang (1) · The Cleveland Clinic (1) · University of California, Davis (1) · University of Coimbra (1) · University of Florida (1) · University of Tartu (1)
Switzerland (9) · United States (4) · Russia (3) · Italy (2) · Estonia (1) · Norway (1) · Portugal (1) · Taiwan (1) · Thailand (1)
Anne Christin Meyer-Gerspach, PD, PhD (3) · Christoph Beglinger, Prof. (2) · Daniele Cardaropoli, DDS (2) · Christoph Beglinger, MD (1) · Christoph Beglinger, Prof (1) · Eino Honkala, PhD (1) · Mare Saag, PhD (1) · Mark L Brantly, MD (1) · Naomi M Hamburg, MD (1) · Orlando Martins (1) · Sergey Morozov, MD, PhD (1) · Shih-Chien Huang, PhD, Associate Professor (1) · So Ran Kwon, DDS, MS, PhD (1)
PMID 22607272, PMID 24095985, PMID 24852946, PMID 27806364, PMID 27875537, PMID 30999906, PMID 36849732, PMID 38842092, PMID 39114916, PMID 42674358